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RATIONALE AND OBJECTIVES: We wanted to improve determination of the glomerular filtration rate (GFR) with plasma clearance techniques because the alternative-renal clearance techniques-may involve inaccurate urine sampling or risk of urinary tract infection when bladder catheterization becomes necessary. Therefore, we compared the renal and plasma clearances of iohexol and chromium-51-ethylenediam
Purpose: Sick leave and unemployment are highly prevalent among people with affective disorders. Their depression severity is disabling and inversely related to having employment. No evidence-based vocational rehabilitation exists for this target group. Knowledge is therefore needed to understand the psychosocial factors that affect depression severity in order to develop new rehabilitation interv
Harmonic periods have wide applicability in industrial real-time systems. Rate monotonic (RM) is able to schedule task sets with harmonic periods up to 100% utilization. Also, if there is no release jitter and execution time variation, RM and EDF generate the same schedule for each instance of a task. This property decreases the jitters which happen during sampling and actuation of the tasks, and
Solar modulated variations in cosmogenic radionuclide production provide both information on past changes in the activity of the Sun and a global synchronization tool. However, to date the use of cosmogenic radionuclides for these applications is almost exclusively based on 10Be records from ice cores and 14C time-series from tree rings, all including archive-specific limitations. We present the f
Purpose: The frst main aim of this study was to illustrate the absorbed dose rate distribution from 177Lu in sections of xenografted prostate cancer (PCa) tumors using high resolution digital autoradiography (DAR) and compare it with hypothetical identical radioactivity distributions of 90Y or 7 MeV alpha-particles. Three dosimetry models based on either dose point kernels or Monte Carlo simulatio
Objective: To achieve universal coverage of reproductive healthcare and drastic reduction in maternal mortality, adequate attention and resources should be given to young women. This study therefore aimed to examine the inequality trends in the use of antenatal care (ANC) services and skilled birth attendance (SBA) within a subgroup of Ghanaian women aged 15-24 years between 2003 and 2014. Design:
In spite of substantial greenhouse gas emissions from photo-degradation of dissolved organic carbon (DOC), little is known about the variability in DOC photo-reactivity. It has been suggested that photo-reactivity depends on the degree of DOC pigmentation. However, recent evidence suggests that also non-colored fractions can be photo-reactive. Furthermore photo-degradation processes interact with
Families often prefer home care to hospital care, and home-care services for ill children are increasing worldwide with limited knowledge of families’ needs during curative and palliative home care. The aim of this study was to elucidate family members’ lived experience when a sick child received home care from county-based primary healthcare services. A descriptive qualitative design was chosen a
In this paper we construct a hierarchical model for spatial compositional data which is used to reconstruct past land-cover compositions (in terms of coniferous forest, broadleaved forest, and unforested/open land) for five time periods during the past 6000 years over Europe. The model consists of a Gaussian Markov Random Field (GMRF) with Dirichlet observations. A block updated Markov chain Monte
In the aircraft industry maximizing availability is essential. Maintenance schedules must therefore be opportunistic, incorporating preventive maintenance activities within the scheduled as well as the unplanned ones. At the same time, the maintenance contractor should utilize opportunistic maintenance to enable the minimization of the total expected cost to have a functional aircraft engine and t
We analyzed the impacts of drought severity on a variety of sectors in a topographically complex basin (the upper Aragón basin 2181 km2) in the Central Spanish Pyrenees. Using diverse data sources including meteorological and hydrological observations, remote sensing and tree rings, we analyze the possible hydrological implications of drought occurrence and severity on water availability in variou
Now more than ever, optimizing resource allocation in cloud computing is becoming more critical due to the growth of cloud computing consumers and meeting the computing demands of modern technology. Cloud infrastructures typically consist of heterogeneous servers, hosting multiple virtual machines with potentially different specifications, and volatile resource usage. This makes the resource alloc
Identification of prostate gold fiducial markers in magnetic resonance imaging (MRI) images is challenging when CT images are not available, due to misclassifications from intra-prostatic calcifications. It is also a time consuming task and automated identification methods have been suggested as an improvement for both objectives. Multi-echo gradient echo (MEGRE) images have been utilized for manu
Atmospheric inverse modeling is a method for reconstructing historical fluxes of green-house gas between land and atmosphere, using observed atmospheric concentrations and an atmospheric tracer transport model. The small number of observed atmospheric concentrations in relation to the number of unknown flux components makes the inverse problem ill-conditioned, and assumptions on the fluxes are nee
Grasslands are key repositories of biodiversity and carbon storage and are heavily impacted by effects of global warming and changes in precipitation regimes. Patterns of grassland dynamics associated with variability in future climate conditions across spatiotemporal scales are yet to be adequately quantified. Here, we performed a global meta-analysis of year and growing season sensitivities of v
Aims. Spatial distribution and growth of dust in a clumpy protoplanetary disk subject to vigorous gravitational instability and fragmentation is studied numerically with sub-au resolution using the FEOSAD code. Methods. Hydrodynamics equations describing the evolution of self-gravitating and viscous protoplanetary disks in the thin-disk limit were modified to include a dust component consisting of
Background: The Swedish healthcare is decentralised to 21 regions. Detailed information on all delivered care in the southernmost region, Skåne, is prospectively collected in the Skåne Healthcare Register (SHR). The data is updated daily and hence a good source for epidemiological studies. However, the diagnostic codes used to identify cancer patients in SHR have not yet been validated. Methods: W
Objective: A widely recognized metabolic side effect of glucocorticoid (GC) therapy is steroid-induced diabetes mellitus (DM). However, studies on the molecular basis of GC-induced pancreatic beta cell dysfunction in human beta cells are lacking. The significance of non-coding RNAs in various cellular processes is emerging. In this study, we aimed to show the direct negative impact of GC on beta c
