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Leptin is a key biological marker related to energy balance and development of diabetes and cardiovascular diseases. Its levels are increased in populations with a high degree of the metabolic syndrome. Life history of evolution has, however, largely taken place under the ecological context of hunting and gathering. In this study, we explored whether the first steps of transition to sedentary agri
Objective: The concentration of the complex between activated protein C (APC) and protein C inhibitor (PCI) is a measure of thrombin generation. We studied whether it can provide information useful for the diagnosis and treatment of arterial vascular disease. Methods: Blood was obtained from 429 vascular patients admitted consecutively during September 2004 to March 2005. The APC-PCI complex was m
Popular Abstract in Swedish Missbrukande kvinnor och mammor har ofta fördömts av samhället och av människor i sin omgivning. De har setts som ansvarslösa kvinnor och olämpliga mammor utifrån en samhällssyn, att barn och missbruk inte går ihop. De livshistoriska intervjuerna med missbrukande kvinnor och mammor, som avhandlingen bygger på visar, att kvinnorna både vill vara respektabla och ta väl haThe aim of the dissertation is to describe the conditions under which substance abusing women live with regard to their families, the substance abuse and treatment. The interaction between the substance abusing women and the institutional expectations is analysed from gender and class perspective. The dissertation is based on interviews with two groups of substance abusing women: 12 mothers, livin
Dietary flavanols and flavonols, flavonoid subclasses, have been recently associated with a lower risk of type 2 diabetes (T2D) in Europe. Even within the same subclass, flavonoids may differ considerably in bioavailability and bioactivity. We aimed to examine the association between individual flavanol and flavonol intakes and risk of developing T2D across European countries. The European Prospec
The aim of this study was to assess the incremental cost effectiveness of on-demand versus prophylactic haemophilia therapy in Germany, Sweden, the United Kingdom and The Netherlands from the third-party payers' perspective. Using a decision tree model, the cost effectiveness of on-demand versus prophylactic therapy was analysed by extrapolating data from the European Haemophilia Economic Study to
Increased mortality risks associated with smoking are well established among men. There are very few population-based studies comprising a sufficient number of heavily smoking women, measuring the direct effect of smoking on mortality risks. Between 1974 and 1992, 8,499 women and 13,888 men attended a health screening programme including reporting of smoking habits. Individuals were followed for t
Background: Current therapies for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis are limited by toxicity. Objective: To compare pulse cyclophosphamide with daily oral cyclophosphamide for induction of remission. Design: Randomized, controlled trial. Random assignments were computer-generated; allocation was concealed by faxing centralized treatment assignment to providers at the
Popular Abstract in Swedish Variabilitet i ett läkemedels farmakokinetiska (hur ett läkemedel omsätts i kroppen) och farmakodynamiska (vilken effekt ett läkemedel har) egenskaper kan resultera i att olika individer som erhållit samma dos av ett läkemedel får olika effekter av läkemedel. Biverkningar eller utebliven effekt kan innebära allvarliga konsekvenser för den enskilda individen. VariabiliteVariability in pharmacokinetic and pharmacodynamic parameters between individuals can be due to intrinsic and extrinsic factors. In this thesis three different areas regarding sources of variability have been investigated. 1. Formulation properties as an extrinsic source of variability. Lipophilic substances often have poor oral bioavailability and high inter- and intraindividual variability. High
CONTEXT: Carpal tunnel syndrome (CTS) is a cause of pain, numbness, and tingling in the hands and is an important cause of work disability. Although high prevalence rates of CTS in certain occupations have been reported, little is known about its prevalence in the general population. OBJECTIVE: To estimate the prevalence of CTS in a general population. DESIGN: General health mail survey sent in Fe
Lund's Climate Alliance was initiated 2010 by the municipality of Lund, in southern Sweden, to support local climate adaptation and mitigation efforts. The purpose of this paper is to investigate what each member of Lund's Climate Alliance believes will be necessary to realize sustainability goals particular to their organization in the future. The study thereby points to new topics, activ
The Department of Automatic Control at Lund University annually gives a project course in Automatic Control (FRTN40). The course is given at the advanced level (7.5 ECTS credits), and the students work in small teams to achieve a common goal. The projects typically involve a real-world estimation or control problem with relevance to industrial or other applications. In this course, the students ge
Syftet med examensarbetet är att undersöka hur fastighetsbildningen för jordbruksändamål kan anpassas till det moderna jordbruket. Nedan följer bakgrunden till mina förslag på anpassning av fastighetsbildningen till det moderna jordbruket: Jordbrukarna föredrar stora jordbruksfastigheter. Idag är det bara riktigt stora jordbruksfastigheter som anses skyddsvärda enligt 3 kap. 6 § FBL. Det är vikt
The effect of future changes in temperature and precipitation patterns on arctic ecosystem functioning is often assessed using state-of-the-art ecosystem models. Many models however lack detailed representation of wintertime processes, as pointed out by recent studies (Wang et al. 2016, Slater and Lawrence 2013). This bias may influence the derived outputs, such as soil temperature, permafrost ext
WADA ansvarar för antidopingarbetet inom idrottsvärlden. Arbetet består främst av att utveckla harmoniserade antidopingregler som sträcker sig över flera sporter och länder. Mer specifikt upprätthåller organisationen en lista över förbjudna preparat som idrottarna inte får ertappas bruka. Dessutom har de utvecklat ett system för dopingtestning och ett övervakningssystem som går ut på att idrottareWADA is responsible for the anti-doping work within the world of sports. The work mainly consists of creating harmonized anti-doping policies that span multiple sports and countries. More specifically the organization of WADA maintains a list of prohibited substances that the athletes must not be caught using. Additionally, they developed a doping testing system and invented a surveillance system
Förorenade områden har länge varit ett stort miljöproblem i Sverige. Kostnaden för att avhjälpa föroreningsskador är ofta stor. I syfte att undvika att sådana kostnader belastar stadsbudgeten har regler om avhjälpandeansvar förts in i 10 kap. MB. I första hand åligger avhjälpandeansvaret verksamhetsutövaren, det vill säga den som bedriver eller har bedrivit en verksamhet eller vidtagit en åtgärd sContaminated areas have long been a major environmental problem in Sweden. The cost of repairing pollution damage is often high. In order to avoid such costs being charged to the national budget rules on remedial liability have been introduced in Chapter 10 of the Environmental Code. The primary liability lies with the operator, i.e. the one who conducts or has conducted an activity or taken measu
During the last 30 years the Swedish defence policy has shifted from a policy of neutrality to a policy of solidarity. In connection to this shift in policy the direction of the defence went from domestic to international and then back to domestic again. This paper seeks to examine how these shifts of direction has affected the methods of the military instrument of power. Through strategic theory,
Objective. The incidence of prostate cancer in Sweden is increasing rapidly, as is treatment with curative intent. Radical prostatectomy (RP) is currently commonly performed, either within or outside large high-volume centres. The aim of this study was to assess the 30-day mortality rate after RP in Sweden. Material and methods. In this nationwide population-based study, all men diagnosed with loc
Objective The complex genetic aetiology underlying irritable bowel syndrome (IBS) needs to be assessed in large-scale genetic studies. Two independent IBS cohorts were genotyped to assess whether genetic variability in immune, neuronal and barrier integrity genes is associated with IBS. Design 384 single nucleotide polymorphisms (SNPs) covering 270 genes were genotyped in an exploratory cohort (93
Objectives The aim of this study was to confirm the influence of TNFSF4 polymorphisms on systemic sclerosis (SSc) susceptibility and phenotypic features. Methods A total of 8 European populations of Caucasian ancestry were included, comprising 3014 patients with SSc and 3125 healthy controls. Four genetic variants of TNFSF4 gene promoter (rs1234314, rs844644, rs844648 and rs12039904) were selected
Background: Selective dorsal rhizotomy (SDR) is a well accepted neurosurgical procedure performed for the relief of spasticity interfering with motor function in children with spastic cerebral palsy (CP). The goal is to improve function, but long-term outcome studies are rare. The aims of this study were to evaluate long-term functional outcomes, safety and side effects during five postoperative y
