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Worldwide, and especially in Western civilizations, most of the staple diets contain high amounts of fat and refined carbohydrates, leading to an increasing number of obese individuals. In addition to inducing metabolic disorders, energy dense food intake has been suggested to impair brain functions such as cognition and mood control. Here we demonstrate an impaired memory function already 3 days
BACKGROUND: A distinctive feature of type 2 diabetes is inability of insulin-secreting beta-cells to properly respond to elevated glucose eventually leading to beta-cell failure. We have hypothesized that an abnormally increased NO production in the pancreatic islets might be an important factor in the pathogenesis of beta-cell dysfunction. PRINCIPAL FINDINGS: We show now that islets of type 2 spo
BACKGROUND: The Tensin family of intracellular proteins (Tensin1, -2, -3 and -4) are thought to act as links between the extracellular matrix and the cytoskeleton, and thereby mediate signaling for cell shape and motility. Dysregulation of Tensin expression has previously been implicated in human cancer. Here, we have for the first time evaluated the significance of all four Tensins in a study of
PKCepsilon (protein kinase Cepsilon) is a serine/threonine kinase, and a member of the PKC family of isoforms. The different PKC isoforms regulate many cellular processes of importance for disease. It is therefore desirable to obtain tools to specifically modulate the activity of the individual isoforms and to develop markers of PKC activity. The paper by Durgan et al. in this issue of the Biochem
The purpose of this work was to study the performance and reliability of a test of fast alternating forearm movements and its relationship with measures of lower extremity function in older women with dementia.
Obese subjects have increased number of enlarged fat cells which are reduced in size but not number in post-obesity. We performed DNA methylation profiling in fat cells with the aim of identifying differentially methylated DNA sites (DMS) linked to adipose hyperplasia (many small fat cells) in post-obesity.
Infections in cystic fibrosis (CF), often involving Pseudomonas aeruginosa, result from a dysregulated airway immunity where one hallmark is the accumulation of necrotic and apoptotic immune cells, in particular neutrophils. In addition, neutrophils actively release DNA, forming neutrophil extracellular traps (NETs) that contain antimicrobial proteins. Altogether, free DNA in complex with actin ac
The lysine-specific crosslinker 3,3'-dithiobis(sulfosuccinimidylpropionate) (DTSSP) is commonly used in the structural characterization of proteins by chemical crosslinking and mass spectrometry and we here describe an efficient two-step LC-MALDI-TOF/TOF procedure to detect crosslinked peptides. First MS data are acquired, and the properties of isotope-labeled DTSSP are used in data analysis to id
When Iran directed over 300 missiles and drones at Israel on April 13, Jordan helped fend off the attack. Initial media reports suggested that several other Arab states assisted in Israel’s defense, efforts they later denied. Nonetheless, a chorus of Israeli leaders, as well as some observers in Washington, interpreted these acts as a sign of a major shift. These Arab states, the argument went, wo
In September 1912, the Russian author Maxim Gorky wrote to the Paris-based Indian revolutionary Madame Cama and asked her to write an article on Indian women and their role in the Indian freedom struggle. Their correspondence highlights several issues: Cama’s central role among Indian and anticolonial nationalists from across the world in early twentieth-century Paris; the inspiration from the 190
This article investigates the emergence and early use of possessive havegot in English. Two hypotheses about its emergence are tested on historical data (c.1460–1760). One hypothesis is based on communicative functionality, suggesting that got was inserted as a ‘pattern preserver’ to compensate for the increased reduction of have. The other hypothesis invokes the conventionalization of an invited
Online platforms devoted to investigating criminal cases or mysteries are often seen as reaching outwards to identify suspects, promote punishment, and try to solve cases. Simultaneously, internal interactions between posters motivate them to contribute, even to outdo one another, and so a team spirit emerges. This article analyzes a lengthy thread on a Swedish Internet discussion forum, FlashbackOnline platforms devoted to investigating criminal cases or mysteries are often seen as reaching outwards to identify suspects, promote punishment, and try to solve cases. Simultaneously, internal interactions between posters motivate them to contribute, even to outdo one another, and so a team spirit emerges. This article analyzes a lengthy thread on a Swedish Internet discussion forum, Flashback
Objectives: To study the agreement between clinical axial spondyloarthritis (axSpA) diagnoses and fulfilment of the Assessment of SpondyloArthritis international Society (ASAS) axSpA and modified New York (mNY) classification criteria, and to compare disease/health status between axSpA subtypes. Method: Patients with prevalent, clinical axSpA attending a rheumatology clinic were enrolled in a cros
Intact adipose tissue function is essential to maintain glucose and lipid homeostasis. To study the impact of altered adipose tissue function on whole-body metabolism, diet-induced obesity in mice is frequently used as a model organism. In the current study, we have examined health-promoting effects of a lingonberry supplemented diet. We found C57BL/6J mice fed a high-fat diet supplemented with li
Background: Epidemiologic studies of associations between folate intake and breast cancer are inconclusive, but folate and other plant food nutrients appear protective in women at elevated risk. Objective: The objective was to examine the association between folate intake and the incidence of postmenopausal breast cancer. Design: This prospective study included all women aged >= 50 y (n = 11699) f
