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Drug design based on the structure of specific enzymes playing a role in carcinogenesis, e.g. tyrosine kinases, has been successful at identifying novel effective anticancer drugs. In contrast, no success has been achieved in drug design attempts, in which transcription factors or DNA-transcription factor complexes involved in the pathogenesis of human neoplasms were targeted. This failure is like
To understand the developmental trajectories in early lymphocyte differentiation, we identified differentially expressed surface markers on lineage-negative lymphoid progenitors (LPs). Single-cell polymerase chain reaction experiments allowed us to link surface marker expression to that of lineage-associated transcription factors (TFs) and identify GFRA2 and BST1 as markers of early B cells. Funct
Importance: Prenatal exposure to phthalates has been associated with neurodevelopmental outcomes, but little is known about the association with language development. Objective: To examine the association of prenatal phthalate exposure with language development in children in 2 population-based pregnancy cohort studies. Design, Setting, and Participants: Data for this study were obtained from the
BACKGROUND: Tuberculosis (TB) is the leading cause of death for individuals infected with Human immunodeficiency virus (HIV). Conversely, HIV is the most important risk factor in the progression of TB from the latent to the active status. In order to manage this double epidemic situation, an integrated approach that includes HIV management in TB patients was proposed by the World Health Organizati
Intracerebral haemorrhage and small vessel ischaemic stroke (SVS) are the most acute manifestations of cerebral small vessel disease, with no established preventive approaches beyond hypertension management. Combined genome-wide association study (GWAS) of these two correlated diseases may improve statistical power to detect novel genetic factors for cerebral small vessel disease, elucidating unde
BACKGROUND: Spatial epidemiological analyses primarily depend on spatially-indexed medical records. Some countries have devised ways of capturing patient-specific spatial details using ZIP codes, postcodes or personal numbers, which are geocoded. However, for most resource-constrained African countries, the absence of a means to capture patient resident location as well as inexistence of spatial d
3-Methyl-1,2,3-butanetricarboxylic acid (MBTCA) is a secondary organic aerosol and can be used as a unique emission marker of biogenic emissions of monoterpenes. Seasonal variations and differences in vegetation cover around the world may lead to low atmospheric MBTCA concentrations, in many cases too low to be measured. Hence, an important
Leptospirosis is a zoonotic disease found wherever human is in direct or indirect contact with contaminated water and environment. Considering the increasing number of cases of this disease in the northern part of Iran, identifying areas characterized by high disease incidence risk can help policy-makers develop strategies to prevent its further spread. This study presents an approach for generati
IntroductionConsidering that on average in developed countries we spend about 65% of our time in private homes, understanding the exposures in homes is of outmost importance. Aerosol concentrations indoors come from indoor sources, infiltrate from outdoors and can be formed from precursors both of indoor and outdoor origin. Several characteristics and processes influence the properties of aerosols
Spatiotemporal analysis of long-term changes in air temperature is of prime importance for climate change research and the development of effective mitigation and adaptation strategies. Although there is considerable research on air temperature change across the globe, most of it has been on linear trends and time series analysis of nonlinear trends has not received enough attention. Here, we anal
Proper emergency evacuation planning is a key to ensuring the safety and efficiency of resources allocation in disaster events. An efficient evacuation plan can save human lives and avoid other effects of disasters. To develop effective evacuation plans, this study proposed a multi-objective optimization model that assigns individuals to emergency shelters through safe evacuation routes during the
Grön infrastruktur för bevarande av biologisk mångfald Grön infrastruktur för bevarande av biologisk mångfald BECC POLICY BRIEF | 07 · 2020 BECC POLICY BRIEF | 07 · 2020 Grön infrastruktur för bevarande av biologisk mångfald MARIA VON POST, Centrum för miljö- och klimatforskning, Lunds universitet JOHAN EKROOS, Centrum för miljö- och klimatforskning, Lunds universitet JOHANNA ALKAN OLSSON, Centr
https://www.cec.lu.se/sites/cec.lu.se/files/gron_infrastruktur.pdf - 2026-07-17
FORESTRY, AIR POLLUTANTS AND MULTIPLE USE ASPECTS ON BERRY PRODUCTION OF FORESTS IN SOUTH SWEDEN by Georgios Gaitanis Lund University Master' s Programme in Environmental Sciences Honours Thesis Supervisor: Bengt Nihlgård Department of Plant Ecology Lund University Summary Various methods of forest management affect the occurrence of berry species in many different ways. It is also known that atmo
https://www.lumes.lu.se/sites/lumes.lu.se/files/gaitanis_georgios.pdf - 2026-07-17
Manual till ISP 2017 Användarhandledning till ISP-system Individuella studieplaner för doktorander vid Ekonomihögskolan & Samhällsvetenskapliga fakulteten uppdaterad 2017-12-12 Manual till ISP-system 1 Manual till ISP-system uppdaterad 2017-12-12 1 Inledning ...........................................................................................................................................
https://www.sam.lu.se/internt/sites/sam.lu.se.internt/files/manual-till-isp-20171212.pdf - 2026-07-17
Microsoft Word - ISP-användarhandledning doktorand-handledare_20201124_eng.docx 2020 ISP system user manual Individual study plans for doctoral students at the Faculty of Medicine Updated 7 September 2020 ISP system manual 1 ISP system manual Updated 7 S e p t e m b e r 2020 1 Introduction ............................................................................................................
Microsoft Word - Neurology Research Unit Coordinator infrastructure report 211004 MP (kopia).docx Multipark infrastructure report form 2021 Neurology Research Unit Coordinator [Per Odin] 1. Short description of the infrastructure. The neurology research unit is located on the ground level of the Wigert building (Remissgatan 4, Skane university hospital, Lund). It consists of 9 office rooms and 4 r
Instruktion för att lägga in samverkansprojekt i LUCRIS LUNDS UNIVERSITET Alla anställda med forskande roll på Samhällsvetenskapliga fakulteten ska redan ha lagt in information i LUCRIS om sina forskningsprojekt och publikationer, enligt den miniminivå som finns att hitta på Sam- bibs hemsida. Nu ska du också lägga in dina projekt och aktiviteter som innefattar samverkan med externa aktörer, initi
https://www.psy.lu.se/sites/psy.lu.se/files/lucris_samverkansprojekt.pdf - 2026-07-17
