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OBJECTIVE: To investigate the impact of exercise therapy on molecular biomarkers related to cartilage and inflammation in people at risk of, or with established, knee osteoarthritis by conducting a systematic review of randomized controlled trials (RCTs).METHODS: Literature search up to September 2017 in five major databases with no restriction on publication year or language. Data were extracted
Background: Circulating biomarkers can facilitate diagnosis and risk stratification for complex conditions such as heart failure (HF). Newer molecular platforms can accelerate biomarker discovery, but they require significant resources for data and sample acquisition. Objectives: The purpose of this study was to test a pragmatic biomarker d
Farmers know much more than we think, and they are keen to improve their knowledge in order to improve their farms and increase their income. On the other hand, decision-makers, organizations, and researchers are increasing their use of citizen volunteers to strengthen their outcomes, enhance project implementation, and approach ecosystem sustainability. This paper assesses the role of citizen sci
Background: Patients with hand eczema often describe symptoms such as pain, clumsiness and difficulty flexing their fingers, thus impairing the function of the hand. Objective: The aim of this study was to investigate whether hand eczema is associated with a measurable impairment of hand strength and dexterity. We also studied the relationship between hand function and the ability to perform activ
Background: Medical devices are increasingly being reported to cause contact allergic dermatitis reactions. Objective: Review of patients with diabetes type I referred for suspected allergic contact dermatitis to insulin pump or glucose sensor systems. Method: We have reviewed 11 referred diabetes mellitus patients investigated for allergic contact dermatitis reactions to medical devices and speci
Type 2 diabetes is a multifactorial disease with multiple underlying aetiologies. To address this heterogeneity a previous study clustered people with diabetes into five diabetes subtypes. The aim of the current study is to investigate the aetiology of these clusters by comparing their molecular signatures. In three independent cohorts, in total 15,940 individuals were clustered based on five clin
BACKGROUND: The COVID-19 pandemic has highlighted the importance of evidence-informed priority setting and situational analysis in pandemic preparedness and response. Health Technology Assessment (HTA) has been identified as an essential tool for evidence-informed decision-making in healthcare. However, the potential role of HTA in pandemic preparedness and response in Africa has yet to be explore
BACKGROUND: The coronavirus disease 19 (COVID-19) pandemic has spread globally, causing extensive illness and mortality. In advance of effective antiviral therapies, countries have applied different public health strategies to control spread and manage healthcare need. Sweden has taken a unique approach of not implementing strict closures, instead urging personal responsibility. We analyze the res
Welding fumes include agglomerated particles built up of primary nanoparticles. Particles inhaled through the nose will to some extent be deposited in the protein-rich nasal mucosa, and a protein corona will be formed around the particles. The aim was to identify the protein corona formed between nasal lavage proteins and four types of particles with different parameters. Two of the particles were
Selective Serotonin Reuptake Inhibitors (SSRIs) may hold therapeutic benefits for people with Alzheimer’s disease (AD). SSRIs may perturb AD progression, or the conversion from MCI to AD, via increased neurogenesis, reduced oxidative stress and/or favourable Amyloid-β Precursor Protein (AβPP) processing. This study used iPSC derived cortical neuronal cells carrying 3 different PSEN1 mutations, to
This study examines how national healthcare initiatives focused on person-centered care are put into practice within Sweden's healthcare system. It analyses how these national policies are represented and implemented in accreditation documents across six Swedish regions—Skåne, Västra Götaland, Jönköping, Halland, Kronoberg, and Östergötland. The research uses qualitative document analysis to e
There are currently numerous web services that provide the user with the opportunity to download geodata. These services are often different regarding what type of data they provide and the way they distribute the data. Another aspect that differs between these services is if the download of geodata is free of charge (open) or subject to a fee. There is currently a trend in the society striving to
Varje år får cirka tio spädbarn bo på anstalt eller häkte tillsammans med en förälder som befinner sig där. Dessa barn får leva under samma institutionsvillkor som sina föräldrar. Rätten anser ändå att det är för barnets bästa att få bo med en förälder och har därför reglerat saken i flera juridiska nivåer för att garantera att barnperspektivet tillgodoses. I samhället existerar dock fler regleran
