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The contributions of cortico-cerebellar and cortico-striatal circuits to timing and time perception have often been a point of contention. In this review we propose that the cerebellum principally functions to reduce variability, through the detection of stimulus onsets and the sub-division of longer durations, thus contributing to both sub-second and supra-second timing. This sensitivity of the c
Popular Abstract in Swedish I avhandlingen beskrivs och analyseras den svenska dagspressens hantering av doping och dopingöverträdelser inom internationell elitidrott. Artiklarna studeras med hjälp av följande tre frågeställningar: (1) Vad utmärker medieinnehållet om sport och doping? (2) Vilken bild av den sociala ordningen skymtar fram i detta mediematerial? (3) Vad berättar medieskandaler kringThe study analyses how the Swedish press dealt with doping and transgressions of the doping rules within international professional sports between 1996 and 2004. Three main research questions have been used in the research process: (1) What characterizes these media texts about sports and doping? (2) How is the social order pictured in the media texts? (3) What do media scandals about sport stars
Incorporating the conceptual resources of the ontological argument for the existence of God into the underlying rationale of the cosmological ditto, I here present and defend a ‘cosmontological’ synthesis: an a posteriori argument for the existence of an all-perfect GOD: a being who, in virtue of being whatever it is better to be than not to be, is that than which a greater cannot be thought. Cent
Vasopressin and oxytocin are synthesised in the hypothalamus and released to the blood stream via the posterior lobe of the hypophysis. Research during later years has shown that these peptides are also produced in other parts of the brain. The secretion to plasma is stimulated by oestrogen, an effect which is counteracted by progestagen. During delivery the fetus can also produce substantial amou
B vitamins and polymorphisms in genes coding for enzymes involved in one-carbon metabolism may affect DNA synthesis and methylation and thereby be implicated in carcinogenesis. Previous data on vitamins B2 and B6 and genetic polymorphisms other than those involving MTHFR as risk factors for gastric cancer (GC) are sparse and inconsistent. In this case-control study nested within the European Prosp
Background and Aims: Spontaneous type 1 diabetes (T1D) in the BioBreeding (BB) rat mimics human T1D as the rats experience weight loss, polydipsia, polyuria, ketoacidosis, onset during puberty and insulin-dependency within a day after diagnosis. Because the DP rat develops T1D spontaneously, it is a prime laboratory animal for dissecting the genetics of T1D susceptibility without the need for exte
Groin pain is common in soccer players. Comparison of results from different studies, especially between genders, is difficult as studies use different definitions and data collection procedures. Therefore we conducted a study of both male and female soccer players enabling direct gender comparison.
Long--term intensive endurance training leads to increased left ventricular mass and increased left ventricular end--diastolic and left atrial end--systolic diameters. Different types of sports tend to give rise to distinct morphological forms of the athlete's heart. However, the sport--specific aspects have not been fully investigated in female athletes. The purpose of the present study was to in
This guideline aims to describe the complement system and the functions of the constituent pathways, with particular focus on primary immunodeficiencies (PIDs) and their diagnosis and management. The complement system is a crucial part of the innate immune system, with multiple membrane-bound and soluble components. There are three distinct enzymatic cascade pathways within the complement system,
Atrial fibrillation (AF) is a common disease with a high prevalence in the adult population. Treatment of AF encompasses antiarrhythmic drugs and catheter ablation to reduce symptoms. The aim of this thesis was to study how to best alleviate symptoms of AF in a safe and efficient way comparing pharmacological treatment and the two dominating catheter ablation techniques, cryoballoon (CRYO) ablatio
During the twentieth century, Sweden became known as a country with an unusually egalitarian distribution of income and wealth, an encompassing welfare state, and an exceptionally strong social democracy. It is commonplace among historians and social scientists to consider these equal outcomes of the twentieth century as the logical end result of a much longer historical trajectory of egalitariani
Importance: Information about how risk for bipolar disorder is transmitted across generations and how parental risk for bipolar disorder relates to their children's risk for schizophrenia and major depression is limited. Objective: To evaluate the sources of parent-offspring transmission of bipolar disorder and its familial cross-generational association with schizophrenia and major depression. De
Objective: Patient-provider relationships with primary care and need for hospitalisations are related within the complex networks comprising healthcare. Our objective was to analyse mean days hospitalised, using registration status (active or passive listing) with a provider and number of consultations as proxies of patient-provider relationships with primary care, adjusting for morbidity burden,
Grass ley and whole-crop cereals used for biogas production are often finely chopped for subsequent ensiling and anaerobic digestion. Chopping can impact not only ensiling stability, digestibility and risk of process hick-ups in the digester but also harvesting capacity and fuel consumption. Based on field experiment data, the aim of this study was to investigate how three different nominal cuttin
Objective. To analyze the characteristics of anti-RNA polymerase III antibodies (anti-RNAP3)- positive patients with systemic sclerosis (SSc) in the European League Against Rheumatism Scleroderma Trials and Research group (EUSTAR) registry with a focus on the risk of cancer and the characteristics of malignancies, and the aim to provide guidelines about potential cancer screening in these patients
Drying has been used for thousands of years to preserve foods. One of the first methods used was open air sun drying which exposes foods directly to solar radiation and ambient air. This method is still used today around the world but it remains underdeveloped on the small-scale for two main reasons. The first is that it can be unhygienic since the food is easily contaminated by pests, dust or mic
BACKGROUND: There are multiple options for the treatment of thumb carpometacarpal joint osteoarthritis (CMC1 OA), with evidence for pain relief and improved function. Although simple trapeziectomy has the lowest complication risk, tendon suspension of the first metacarpal and interposition is still the most commonly used surgical procedure in patients with CMC1 OA. Although there are several repor
BackgroundHigh quality primary care is expected to be the basis of many health care systems. Expectations on primary care are rising as societies age and the burden of chronic disease grows. To stimulate adherence to guidelines and quality improvement, audit and feedback to professionals is often used, but the effects vary. Even with carefully designed audit and feedback practices, barriers relate
Summary: This narrative review describes efforts to improve the care and prevention of fragility fractures in New Zealand from 2012 to 2022. This includes development of clinical standards and registries to benchmark provision of care, and public awareness campaigns to promote a life-course approach to bone health. Purpose: This review describes the development and implementation of a systematic a
