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En två-kolonn MCSGP process för upprening av Liraglutid genomfördes i laboratorieskala. Den här processen är inte en kommersiell uppreningsprocess, utan att den är ett modellsystem med en realistisk peptidblandning och med en icke-kommersiell harts. Först modellerades processen med en konvektiv dispersiv modell för att beskriva koncentrationen genom kolonnen och den steriska massaktionsmodellen föA twin-column MCSGP process for the purification of Liraglutide was implemented at lab scale. This process is not a commercial separation step, but it is a model system with a realistic peptide mixture and with a non-commercial resin. First, the process was modeled using a convective dispersive model to describe the concentration along the column and the steric mass action model to describe the ad

This master’s thesis report describes the development of a new system for control and monitoring of a helium liquefaction plant which has been carried out at Kryolab, Lund University. At the plant, helium gas is purified and then cooled in several steps until it condensates. The plant is very similar to the ones constructed today, but Kryolab wished to replace the outdated control system. The new

A model of the Swedish power plant Mälardalen Energi, developed by Solvina AB was simulated in Dymola with different types of control strategies in order to evaluate if they could improve the operational flexibility of the plant and, thus, its ability to deliver frequency control to the Swedish power grid. Several different control strategies and process modifications were tested and compared to p

In order to transform the fossil fuel dependent transport sector the promotion of biofuels has been crucial in the European Union’s transition towards climate neutrality. To ensure the sustainability of biofuels the European Commission published a Delegated Act on March 13th 2019, proposing the gradual phase-out of high emitting biofuels that may cause indirect land use change (ILUC) – one of them

The Light Dark Matter Experiment (LDMX) is a fixed target experiment that will search for dark matter, but is still in the development phase. An important aspect for the experiment is the discrimination of signal and background events. Here this signal and background discrimination is inspected using a machine learning technique called a Boosted Decision Tree (BDT). This is done using Monte Carlo

This thesis set out to continue the development of a short-wave infrared (SWIR) optical parametric amplifier (OPA). The system is based on a Yb-ber chirped pulse amplification (CPA) laser delivering 400 fs long pulses, centered around 1030 nm, at 200 kHz repetition rate and 40 W average power. The thesis focuses on pulse characterization, through use of frequency-resolved optical gating (FROG), of

Cerebral Palsy (CP) has an impact on muscles and movement. This happens due to brain damage before the age of two years. Either sometimes before birth, during childbirth or after birth. According to hjarnfonden.se, 200 children are added annually in Sweden with CP. People living with CP have these weaknesses for the rest of their lives. CP is not progressive disorder, that means brain damage can’

Until recently, the general level of detail in full car crash models has not allowed a physical modeling of rubber bushings with solid elements. This is partly because of the difficulty in modeling the complex characteristic of rubber, but also due to limited understanding of the mechanical properties of rubber materials. The main focus of this Master’s thesis project is to develop a new and im

Asylum seekers and refugees are one of the most demonised and marginalised social groups in Europe. Ireland's current agenda for dealing with refugees and asylum seekers is inadequate. The government of Ireland is aware of the inadequacy of response and has proposed to make a number of changes that will improve the standard of living for those who chose to apply for inclusion in Ireland. Howev

Scientific summary: Ground settlement due to groundwater drainage during construction is important to be considered since ground settlement may cause severe building damages. The calculation of ground settlement contained several parameters with different magnitude of uncertainties. Thus a risk evaluation of ground settlement is necessary. The aim of this thesis was first to build a soil strata mo

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the benefits and harms of clustering of care activities for promoting development and preventing morbidity in preterm infants.

Background: Preterm and low birth weight infants are at an early stage of development, and do not receive adequate maternal circadian signals. They are often cared for over prolonged periods of hospitalisation in neonatal intensive care units (NICU), where environmental circadian stimuli are lacking. Exposure to artificial light–dark cycles may stimulate the development of the circadian system and

Aromatic side chains are prevalent in protein binding sites, perform functional roles in enzymatic catalysis, and form an integral part of the hydrophobic core of proteins. Thus, it is of great interest to probe the conformational dynamics of aromatic side chains and its response to biologically relevant events. Indeed, measurements of (13)C relaxation rates in aromatic moieties have a long histor

A thermoelastic–plastic body consisting of two phases, a solid and a fluid, each comprising two constituents is considered where one constituent in one phase is allowed to exchange mass with another constituent (of the same substance) in the other phase. A large strain setting is adopted and the formulation applies to general anisotropy and the existence of residual stresses. Generalized forms of

We investigate the enrichment patterns of several delivery scenarios of the volatiles to the atmospheres of ice giants, having in mind that the only well constrained determination made remotely, namely the carbon abundance measurement, suggests that their envelopes possess highly supersolar metallicities, i.e., close to two orders of magnitude above that of the protosolar nebula. In the framework

Zone plates are diffractive optics commonly used in X-ray microscopes. Here, we present a wet-chemical approach for fabricating high aspect ratio Pd/Si zone plate optics aimed at the hard X-ray regime. A Si zone plate mold is fabricated via metal-assisted chemical etching (MACE) and further metalized with Pd via electroless deposition (ELD). MACE results in vertical Si zones with high aspect ratio

This paper presents a single-layer filtering antenna (filtenna) based on a compact square substrate-integrated waveguide (SIW) cavity for millimeter-wave (mmWave) applications. The cavity operates in the fundamental TE110 mode to enable beam scanning, while a central shorting via introduces the TE210 mode, broadening the bandwidth. A radiating slot, placed at high-intensity regions of both modes,