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Research Article Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus Natalia Avaliani,1 Ulrich Pfisterer,2 Andreas Heuer,2,3 Malin Parmar,2 Merab Kokaia,1 and My Andersson1 1Epilepsy Centre, Lund University Hospital, Lund, Sweden 2Developmental Neurobiology, Lund University, Lund, Sweden 3Molecular Neuromodulation, Lund University, Lund, S
VETENSKAP OCH BEPRÖVAD ERFARENHET VID SBU | 1 VETENSKAP OCH BEPRÖVAD ERFARENHET MILJÖ Vetenskap och beprövad erfarenhet är ett minst sagt viktigt begrepp. Via olika lagar och förordningar påverkar det våra myndigheter. Det påver- kar oss som yrkesutövare och som medborgare. Samtidigt är det något oklart vad som avses. Vad menar vi med vetenskap? Vems eller vilkas beprövade erfarenhet talar vi om o
https://www.vbe.lu.se/sites/vbe.lu.se/files/vbe_miljo_inlaga_webb.pdf - 2026-06-30
We present a dual-wavelength polarimetric measurement method to distinguish species and sexes of disease transmitting mosquitoes in flight. By measuring co- and de-polarized backscattered light at 808 and 1550nm, the degree of linear polarization, wingbeat frequency, reflectance, spectral ratio and glossiness of mosquitoes can be retrieved. Body and wing contributions to these signals can be separ
Conodonts have been a key tool for biostratigraphical, evolutionary and palaeobiogeographical studies, and the GermanicBasin has been one of the most important regions for these studies. However, few modern studies provide systematic data onthe mainly endemic conodonts of the Middle Triassic Germanic Basin. Here we document conodonts from two sections inGermany, one Bithynian in age and the other
Våra ögon är viktiga, inte bara för vårt seende, utan också för att synkronisera vår inre biologiska klocka med dygnets 24 timmar. Den biologiska klockan som styr människors dygnsrytm regleras främst av det mönster av ljus och mörker som vi utsätts för under dygnet.Tidigare trodde man att de klassiska fotoreceptorerna, tapparna och stavarna, var de enda ljuskänsliga cellerna i ögat. På 1980-talet
A supervisory observer is a multiple-model architecture, which estimates the parameters and the states of nonlinear systems. It consists of a bank of state observers, where each observer is designed for some nominal parameter values sampled in a known parameter set. A selection criterion is used to select a single observer at each time instant, which provides its state estimate and parameter value
Novel Sm2O3−NiO composite was prepared as the functional electrolyte for the first time. The total electrical conductivity of Sm2O3−NiO is 0.38 S cm−1 in H2/air condition at 550 °C. High performance, e.g. 718 mW cm−2, was achieved using Sm2O3−NiO composite as an electrolyte of solid oxide fuel cells operated at 550 °C. The electrical properties and electrochemical performance are strongly depended
Background: As a renewable energy solution, photovoltaics (PVs) are crucial in the transition to a more sustainable energy system. Besides large PV installations, household adoption of PVs will be an important contribution to this transition. However, the adoption of PVs on a household level faces many barriers, with gathering and understanding information being one of the major barriers. The aim
The world has become increasingly telecoupled through distant flows of information, energy, people, organisms, goods, and matter. Recent advances suggest that telecouplings such as trade and species invasion often generate spillover systems with profound effects. To untangle spillover complexity, we make the first attempt to develop a typology of spillover systems based on six criteria: flows from
Floods and wildfires are two critical hazards that impose substantial direct and indirect costs to society, including the resource needs of rescue services. Their occurrence is strongly linked to meteorological conditions, playing a fundamental role in hazard development and assessment. These hazards are notably distinguishable due to opposing weather requirements, wet conditions for floods and dr
The formation and evolution of coastal dunes result from a complex interplay of eco-morphodynamic processes. State-of-the-art models can simulate aeolian transports and morphological dune evolution under certain conditions. However, a model combining these processes for coastal engineering applications was not yet available. This study aims to develop a predictive tool for dune development to info
Biochemical differences between sexes can also be seen in non-sexual organs and may affect organ functions and susceptibility to diseases. It has been shown that there are sex-biased visual perceptions and impairments. Abundance differences of eye proteins could provide explanations for some of these. Exploration of the ocular proteome was performed to find sex-based protein abundance differences
Suppose (f,X, μ) is a measure preserving dynamical system and φ: X → R a measurable function. Consider the maximum process Mn := max{X1, ,Xn}, where Xi = φ ○ fi-1 is a time series of observations on the system. Suppose that (un) is a non-decreasing sequence of real numbers, such that μ(X1 > un) → 0. For certain dynamical systems, we obtain a zero- one measure dichotomy for μ(Mn ≤ un i.o.) dependin
Statistical combinations of searches for charginos and neutralinos using various decay channels are performed using 139 fb^{-1} of pp collision data at sqrt[s]=13 TeV with the ATLAS detector at the Large Hadron Collider. Searches targeting pure-wino chargino pair production, pure-wino chargino-neutralino production, or Higgsino production decaying via standard model W, Z, or h bosons are combine
Measured ice crystal concentrations in natural clouds at modest supercooling (temperature ~>−10°C) are often orders of magnitude greater than the number concentration of primary ice nucleating particles. Therefore, it has long been proposed that a secondary ice production process must exist that is able to rapidly enhance the number concentration of the ice population following initial primary ice
The aim of this study was to understand parents' perspectives on how children and adolescents with autism spectrum disorders (ASD) benefit from a relationship with companion animals. Parents were invited to participate in focus-group discussions. One open-ended question with follow-up questions was asked and the parents' responses were subsequently categorized. Three main themes emerged: the quali
Uncertainty, insufficient information or information of poor quality, limited cognitive capacity and time, along with value conflicts and ethical considerations, are all aspects that make risk management and risk communication difficult. This paper provides a review of different risk concepts and describes how these influence risk management, communication, and planning in relation to forest ecosy
beta-1,4-Gatactosyltransferase 7 (beta 4GalT7) is an essential enzyme in the biosynthesis of glycosaminoglycan (GAG) chains of proteoglycans (PGs). Mammalian cells produce PGs, which are involved in biological processes such as cell growth and differentiation. The PGs consist of a core protein, with one or several GAG chains attached. Both the structure of the PGs and the GAG chains, and the expre
Objective. To investigate in a prospective study the relationship between age, pre-operative status, waiting time and post-operative outcome in patients assigned for unilateral total hip replacement (THR) due to osteoarthritis (OA). Method. One hundred and forty-eight patients (mean age 71 yr) with primary OA of the hip were investigated pre-operatively and 3, 6 and 12 months post-operatively with
