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Chemical, oxidational and diffusional interactions between the tool, chip and cutting environment are known tool wear mechanisms in machining. However, the interaction between tool, coating, workpiece, coolant and atmospheric oxygen can, under favorable conditions, lead to formation of reaction products that retard tool wear. A method with the ability to predict theses interactions, would therefor
The target of zero emissions sets a new standard for industry and industrial policy. Industrial policy in the twenty-first century must aim to achieve zero emissions in the energy and emissions intensive industries. Sectors such as steel, cement, and chemicals have so far largely been sheltered from the effects of climate policy. A major shift is needed, from contemporary industrial policy that ma
A novel and effective approach for determining mechanics and residual stress when turning a component with curved surfaces is presented in this paper. This predictive approach is based on a three-dimensional analytical model to study the distributed mechanics and residual stress caused by vary cutting condition during the machining process. The variation of uncut chip area in this process can be d
The bone tissue formed at the contact interface with metallic implants, particularly its 3D microstructure, plays a pivotal role for the structural integrity of implant fixation. X-ray tomography is the classical imaging technique used for accessing microstructural information from bone tissue. However, neutron tomography has shown promise for visualising the immediate bone-metal implant interface
This book focuses on Public Procurement for Innovation. Public Procurement for Innovation is a specific demand-side innovation policy instrument. It occurs when a public organization places an order for a new or improved product to fulfill certain needs that cannot be met at the moment of the order. The book provides evidence of the potential benefits to public and private actors from the selectiv
The possibility of prosecuting serious international crimes before domestic foreign courts when territorial courts are unwilling and unable to perform this function and international criminal tribunals with suitable competences are unavailable has been intensively debated since the time of the Spanish arrest warrants against Pinochet. The African disapproval of decisions by European courts to exer
This chapter provides an attempt to enable a productive conversation between the budding, interdisciplinary research field of celebrity studies, humanitarianism, and activism and feminist international political economy scholarship. It focuses on the Same Sky shopping initiative – a New York-based ethical trade and shopping initiative supported by a philanthropic foundation with the same name. The
The use of load and structural performance measurement information is vital for efficient structural integrity management and for the cost of energy production with Offshore Wind Turbines (OWTs). OWTs are dynamically sensitive structures subject to an interaction with a control unit exposed to repeated cyclic wind and wave loads causing deterioration and fatigue. This study focuses on the quantifi
Identifying optimal inspection and repair strategies for offshore jacket structures is a challenging task. We present an approach, which is based on recent developments in the field of risk-based operation and maintenance planning at the structural system level. The approach utilizes heuristics to define inspection and repair strategies at the system level and to reduce the search space of possibl
This paper develops the models for the structural performance of the loading and probabilistic characterization for the fatigue and the serviceability limit states for the support structure of offshore wind energy converters. These models and a sensitivity study are part of a risk based assessment and monitoring framework and will be applied for establishing the "as designed and constructed" relia
Smokers are at increased risk for surgical complications. Despite the known benefits of smoking cessation, many perioperative health care providers do not routinely provide smoking cessation interventions. The variation in delivery of perioperative smoking cessation interventions may be due to limited high-level evidence for whether smoking cessation interventions used in the general population ar
Assessing the transport of natural radionuclides in the atmosphere provides a powerful tool to study air mass circulation. Here, we investigated the seasonal atmospheric distribution of the naturally produced 7Be in surface air over Europe between 40° N and 68° N during the period 1975–2018. The results suggest that the inter-annual variability of 7Be reflects production rates of the radionuclide
Gene therapy approaches using viral vectors for the overexpression of target genes have been for several years the focus of gene therapy research against neurological disorders. These approaches deliver robust expression of therapeutic genes, but are typically limited to the delivery of single genes and often do not manipulate the expression of the endogenous locus. In the last years, the advent o
Large drop towers let you experience a couple of seconds of nearly free fall before stopping gracefully in magnetic brakes or bouncing a number of times on compressed air, as in the Turbo Drop tower considered in this work, where many complementary representations are used. An accelerometer taken along on the ride captured the forces experienced by the body, and a pressure sensor provided a simult
Background: The neural crest is a transient embryonic stem cell population. Hypoxia inducible factor (HIF)-2α is associated with neural crest stem cell appearance and aggressiveness in tumors. However, little is known about its role in normal neural crest development. Results: Here, we show that HIF-2α is expressed in trunk neural crest cells of human, murine, and avian embryos. Knockdown as well
Neglected tropical diseases affect most of the underprivileged populations in tropical countries. Among these are chagas and leishmaniasis, present mainly in South and Central America, Africa and East Asia. Current treatments are long and have severe adverse effects, therefore there is a strong need to develop alternatives. In this study, we base our research on the plant metabolite pulchrol, a na
The sexes may have different optima in cognitive traits due to differences in life history strategies and the expense of investing in metabolically costly brain tissue. However, given genetic correlations, each sex could be constrained from reaching its cognitive optimum due to intralocus sexual conflict. We compared learning performance of two male alternative reproductive tactics and females fro
