Sökresultat

Popular Abstract in Swedish Projektioner om framtida klimat i Arktis och subarktis tyder på att drastiska förändrinar väntar regionen under det närmaste århundradet. Inte bara temperaturen spås öka utan även nederbörd, och då framför allt nederbörden under vinterhalvåret. Dessa förändringar kommer sannolikt att ha stor inverkan på miljön i Arktis och subarktis, och stora forksningsansträngningar hClimate projections indicate that Arctic and sub-Arctic regions are facing a significant change in climate during the 21st century. With warmer temperatures precipitation is also expected to increase, and in particular winter precipitation. These changes are likely to have large impacts on the Arctic and subarctic environment, and extensive research has focused on ecosystem-climate interactions in

Chronic myeloid leukemia (CML) stem cells appear resistant to tyrosine kinase inhibitors (TKIs) in vitro, but their impact and drug sensitivity in vivo has not been systematically assessed. We prospectively analyzed the proportion of Philadelphia chromosome-positive leukemic stem cells (LSCs, Ph+CD34+CD38=) and progenitor cells (LPCs, Ph+CD34+CD38+) from 46 newly diagnosed CML patients both at the

Popular Abstract in Swedish Mycorrhiza är en samexistens mellan trädrötter och svampar i jorden. Svampen förser trädet med mineralnäringsämnen från jorden och i utbyte får den socker från trädet. Sockret produceras via fotosyntesen och transporteras sedan ner till rötterna där de förs vidare till svamphyferna. Det har visats att mycorrhizasvampar kan ta upp näringsämnen direkt från mineraler i jEctomycorrhiza are a symbiosis between trees and soil inhabiting fungi. The fungal hyphae ensheath the fine roots creating a mantle and grow in between root cells to create the Hartig net, where the exchange of carbon and mineral nutrients occurs. The ectomycorrhizal fungus is dependent on the host tree to receive the carbon it needs to grow. Trees with different nutrient deficiencies differ in t

Sera from 25 metastatic breast cancer patients and 25 healthy controls were subjected to affinity chromatography using immobilized galectin-1. Serum from the healthy subjects contained on average 1.2 mg per ml (range 0.7-2.2) galectin-1 binding glycoproteins, whereas serum from the breast cancer patients contained on average 2.2 mg/ml (range 0.8-3.9), with a higher average for large primary tumour

Enriching the surface density of immobilized capture antibodies enhances the detection signal of antibody sandwich microarrays. In this study, we improved the detection sensitivity of our previously developed P-Si (porous silicon) antibody microarray by optimizing concentrations of the capturing antibody. We investigated immunoassays using a P-Si microarray at three different capture antibody (PSA

Sammanfattning Användningen av mobila lösningar ökar kontinuerligt på stora såväl som små företag inom olika branscher. Mobila lösningar används inte bara som kommunikationsredskap utan har flera andra funktioner som möjliggör trådlös datakommunikation mellan två parter eller mer, uppkoppling till internet och användning av dess tjänster samt möjligheter att kunna få fordons positionering i realti

Projektet ECOSIMP handlar om förutsättningen att implementera ekosystemtjänstbegreppet (EST-begreppet) i kommunerna, och bland annat om hur kommunala tjänstemän och politiker ser på denna utmaning. En stor intervjustudie genomfördes med tjänstemän och politiker i de 7 kommunerna. I en studie av Malmö stad undersöktes också hur ekosystem-relaterade begrepp har integrerats i översiktsplaner och utve

Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) dat

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and causes serious health complications in individuals with and without type 2 diabetes (T2D). Early diagnosis of NAFLD is important, as this can help prevent irreversible damage to the liver and, ultimately, hepatocellular carcinomas. We sought to expand etiological understanding and develop a diagnostic tool for NAFLD usin

Background The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation is routinely used to assess renal function but exhibits varying accuracy depending on patient characteristics and clinical presentation. The overall aim of the present study was to assess if and to what extent glomerular filtration rate (GFR) estimation based on creatinine can be improved.MethodsIn a cro

We present a theory to compute the stable gap (interparticle) distance between particle chains collected in the pressure node of an acoustic standing wave. The primary and secondary acoustic radiation forces are the two competing forces that act on the particles during the particle chain formation. The stable equilibrium distance between two chains is reached when both forces are in balance. Most

Development of human hematopoietic stem cells and differentiation of embryonic stem (ES) cells/induced pluripotent stem (iPS) cells to hematopoietic stem cells are poorly understood. NOD (Non-obese diabetic)-derived mouse strains, such as NSG (NOD-Scid-il2Rg) or NRG (NOD-Rag1-il2Rg), are the best available models for studying the function of fetal and adult human hematopoietic cells as well as ES/

Two photoactive iron N-heterocyclic carbene complexes [FeII(btz)2(bpy)]2+ and [FeIII(btz)3]3+, where btz is 3,3’-dimethyl-1,1’-bis(p-tolyl)-4,4’-bis(1,2,3-triazol-5-ylidene) and bpy is 2,2’-bipyridine, have been investigated by Resonant Photoelectron Spectroscopy (RPES). Tuning the incident X-ray photon energy to match core-valence excitations provides a site specific probe of the electronic struc

Altered DNA methylation is often seen in malignant cells, potentially contributing to carcinogenesis by suppressing gene expression. We hypothesized that heritable methylation potential might be a risk factor for breast cancer and evaluated possible association with breast cancer for single nucleotide polymorphisms (SNPs) either involving CpG sequences in extended 5'- regulatory regions of candida

Denna avhandling undersöker de politiska orsakerna till reformer av subventioner av fossila bränslen i OECD-länderna mellan 2009 och 2023. Trots att subventioner för fossila bränslen är allmänt erkända som ekonomiskt ineffektiva och miljöskadliga, är de fortfarande djupt rotade, där OECD-länderna tillsammans upprätthåller ett årligt stöd på cirka 100 miljarder US-dollar. Avhandlingen behandlar fråThis dissertation investigates the political determinants of fossil fuel subsidy reform in OECD countries between 2009 and 2023. Despite widespread recognition of their economic inefficiency and environmental harm, fossil fuel subsidies remain entrenched, with OECD countries collectively sustaining around USD 100 billion in annual support. The research addresses why some governments successfully r

BACKGROUND: Gleason grading is the standard diagnostic method for prostate cancer and is essential for determining prognosis and treatment. The dearth of expert pathologists, the inter- and intraobserver variability, as well as the labour intensity of Gleason grading all necessitate the development of a user-friendly tool for robust standardisation.OBJECTIVE: To develop an artificial intelligence

Acute myeloid leukemia (AML) is associated with poor survival, and there is a strong need to identify disease vulnerabilities that might reveal new treatment opportunities. Here, we found that Toll-like receptor 1 (TLR1) and TLR2 are upregulated on primary AML CD34+CD38-cells relative to corresponding normal bone marrow cells. Activating the TLR1/TLR2 complex by the agonist Pam3CSK4 inMLL-AF9-driv