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Proxy variables and the generalizability of study results

When individuals self-select (or are selected) into a study based on factors that influence the outcome, conclusions may not generalize to the full population. To compensate for this, results may be adjusted, for example, by standardization on the set of common causes of participation and outcome. Although such standardization is useful in some contexts, the common causes of participation and outc

Challenges resulting from urban density and climate change for the EU energy transition

Dense urban morphologies further amplify extreme climate events due to the urban heat island phenomenon, rendering cities more vulnerable to extreme climate events. Here we develop a modelling framework using multi-scale climate and energy system models to assess the compound impact of future climate variations and urban densification on renewable energy integration for 18 European cities. We obse

Examining the continuum of resistance model in two population-based screening studies in Sweden

In studies recruited on a voluntary basis, lack of representativity may impair the ability to generalize findings to the target population. Previous studies, primarily based on surveys, have suggested that generalizability may be improved by exploiting data on individuals who agreed to participate only after receiving one or several reminders, as such individuals may be more similar to non-partici

Patterns of simultaneous contact allergies in patients with contact sensitization to oxidised linalool and oxidised limonene

BACKGROUND: Contact allergy rates of linalool and limonene hydroperoxides (HPs) have increased.OBJECTIVES: To demonstrate the patterns of simultaneous positive patch test (PT) reactions and prevalences of multiple contact allergies (MCAs) in patients with contact allergy to linalool and/or limonene HPs.METHODS: A retrospective analysis of consecutive dermatitis patients in 2015-2020 was performed.

Lessons from Ten Years of the International Master’s Program in System-on-Chip

In July 2000 the five-year Swedish national “Socware Research & Education Program” was started. One of the aims of the program was to develop an innovative unique educational curriculum in System-on-Chip design. The program was targeted at undergraduate and graduate. In total the program received USD $15 million funding. In 2005 the program entered a new phase; more than 500 Master’s students

The effects of a cancer diagnosis on the health of a patient's partner : a population-based registry study of cancer in Sweden

The aim of this population-based registry study was to explore how cancer influences the health of partners, by examining the onset of new diagnoses for partners, health care use and health care costs among partners living with patients with cancer. The sample consisted of partners of patients with cancer (N = 10 353) and partners of age- and sex-matched controls who did not have cancer (N = 74 59

The BRCA1-Δ11q alternative splice isoform bypasses germline mutations and promotes therapeutic resistance to PARP inhibition and cisplatin

Breast and ovarian cancer patients harboring BRCA1/2 germline mutations have clinically benefitted from therapy with PARP inhibitor (PARPi) or platinum compounds, but acquired resistance limits clinical impact. In this study, we investigated the impact of mutations on BRCA1 isoform expression and therapeutic response. Cancer cell lines and tumors harboring mutations in exon 11 of BRCA1 express a B

Prediction of clinical progression after radical prostatectomy in a nationwide population-based cohort

Objective: The aim of this study was to create a model for predicting progression-free survival after radical prostatectomy for localized prostate cancer. Material and methods: The risk of biochemical recurrence (BCR) was modelled in a cohort of 3452 men aged 70 years or younger who were primarily treated with radical prostatectomy after being diagnosed between 2003 and 2006 with localized prostat

Making Predictive Biomarkers Readily Available

Detection of the androgen receptor splice variant 7 in circulating tumor cells and in prostate cancer tissue harbors prognostic and predictive information. The true value of measuring androgen receptor splice variant 7 to predict response to different treatments is still unproven but is currently under evaluation in clinical trials.

Interpretation of conventional survival analysis and competing risk analysis : An example of hypertension and prostate cancer

Most clinical studies use conventional methods for survival analysis and calculate the risk of the event of interest, however, it is important to understand that the study population is also at risk of competing events, for example death from other causes. Moreover, the risk of competing events may be dependent on the participants' characteristics. Whether competing risks are taken into account or

Monocyte-derived macrophages contribute to spontaneous long-term functional recovery after stroke in mice

Stroke is a leading cause of disability and currently lacks effective therapy enabling long-term functional recovery. Ischemic brain injury causes local inflammation, which involves both activated resident microglia and infiltrating immune cells, including monocytes. Monocyte-derived macrophages (MDMs) exhibit a high degree of functional plasticity. Here, we determined the role of MDMs in longterm

Comprehensive analysis

Comprehensive analysis of microRNA expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor Development. 2015 Sep 15; 142(18): 3166–3177. doi: 10.1242/dev.122747: 10.1242/dev.122747 PMCID: PMC4582174 PMID: 26395143 Comprehensive analysis of microRNA expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor Marie

https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/comprehensive_analysis_.pdf - 2026-06-07

Politis et al sci transl med 2010

Politis 1..7 DOI: 10.1126/scitranslmed.3000976 , 38ra46 (2010);2 Sci Transl Med , et al.Marios Politis Patients with Neural Transplants Serotonergic Neurons Mediate Dyskinesia Side Effects in Parkinson's Editor's Summary The Two Faces of Fetal Grafts bioengineered or stem cells. here, is important in that it will inform future treatments with grafts that consist of cells from other sources, such a

https://www.wnc.lu.se/sites/wnc.lu.se/files/politis_et_al_sci_transl_med_2010.pdf - 2026-06-07

Is protokoll 2019-9 191210 m bilaga

LUNDS UNIVERSITET Institutionen för Psykologi I nstitutionsstyrelsen lnstitutionsstyrelsens protokoll Närvarande Ordförande Sekreterare Ledamöter Närvaro- och yttranderätt Anmält förhinder § 1 Justeringsperson § 2 Dagordning § 3 Föregående protokoll § 4 Uppföljning beslut och ärenden a) Lägesrapport befordran till och rekrytering av professorer b) Lägesrapport förslaget att kalla professor, se IS

https://www.psy.lu.se/sites/psy.lu.se/files/is_protokoll_2019-9_191210_m_bilaga.pdf - 2026-06-07

Elevations in blood glucose before and after the a

The Journal of Clinical Investigation R E S E A R C H A R T I C L E 1 Introduction The supply, uptake, and metabolism of glucose are cornerstones of energy production for cell and organ function and survival. Blood glucose levels are regulated by a multitude of hormones and factors, but ultimately by the response of pancreatic islet cells to the glucose concentration and the abilities of cells and

https://www.teddy.lu.se/sites/teddy.lu.se/files/2022-12/Elevations_in_blood_glucose_before_and_after_the_a.pdf - 2026-06-07

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At the End of the World Newsletter – 15 December 2023 At the End of the World Newsletter – 15 December 2023 Dear all, This is the fourth newsletter for the  At the End of the World research program, housed at Lund University. It is the last from our first year of activity. If you’re receiving this email, it’s because you’ve been subscribed to our mailing list. Below, we’ll fill you in on some upco

https://www.endoftheworld.lu.se/at-the-end-of-the-world-newsletter-15-december-2023/ - 2026-05-21

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COSB45: Social Movements in East and South-East Asia Literature List Literature Introduction COSB45 is a first-cycle elective course offered by the Centre for East and South-East Asian Studies and open to general enrolment. The course is a distance course, which provides a thorough overview of a comprehensive overview of social movements in East and South- East Asia. It comprises issues including

https://www.ht.lu.se/media/utbildning/dokument/kurser/COSB45/20252/COSB45_literature_list_2025.pdf - 2026-06-02

Cambridge och Lund i nytt samarbete för klimatlösningar

Forskare och studenter från University of Cambridge och Lunds universitet möttes på årets hållbarhetskonferens med ett gemensamt mål: att utveckla ny tvärvetenskaplig kunskap och skala upp de lösningar som redan finns på vår tids akuta kriser – från klimatförändringar och kollapsande ekosystem till en energisektor i omställning. – Problemen är så komplexa att vi måste arbeta tillsammans och över ä

https://www.hallbarhet.lu.se/cambridge-och-lund-i-nytt-samarbete-klimatlosningar - 2026-06-05