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The expansion of the European Union's (EU) regulatory sphere creates conflicts of sovereignty between the EU and its member states, and third countries that lack a possibility to participate in the making of those laws and policies. The conflict is epitomised in the concept of the Union's decision-making autonomy. Albeit stringently applied, the concept is ambiguous and undefined. This article end
Inflammation and subsequent endothelial dysfunction are main players in the vascular component of hypertension, and recent findings points to a key role of Sphingosine- 1-Phosphate and its signaling pathways in its pathophysiology. In neurodegenerative disorders such as Alzheimer’s disease, hypertension is the main modifiable risk factor, but insights regarding S1P receptor modulation in response
This Master Thesis aims to show an approach to the design of parallel robots,specifically the development of its kinematics. To do this, screw theory will be used, focusing on its theoretical bases and taking it later to practice. First, a theoretical definition of the inverse and forward kinematics of a parallel robot is carried out. Subsequently, algorithms are generated in Python that verify t
Aspects of Error Quantification and Evaluation in Digital Elevation Models for Glacier Surfaces This study explores methods to quantify and evaluate error in digital elevation models (DEMs) built from remotely sensed elevation data of the Hintereisferner glacier. A special focus lies on glacier surfaces because glaciers are often inaccessible for field observations but at the same time prone to m
This study aims to compare the effectiveness of different Pharmacokinetic-Pharmacodynamic (PK-PD) models for administering Propofol and Remifentanil, two critical agents in anesthesia. Initially, different PK models were introduced: one for Propofol based on the Schnider model and another for Remifentanil using the Minto model. Alternatively, both drugs were modeled using the Eleveld models. The P
Background: Staphylococcus aureus bacteraemia (SAB) may lead to periprosthetic joint infections (PJI) via haematogenous spread of bacteria to the joint. Due to the risk of PJI, patients with SAB and prosthetic joint are recommended prolonged antibiotic treatment. The aim of the study was to assess the risk of PJI during SAB, and to evaluate if short treatment duration affects outcomes in patients
Navigating complex environments requires Unmanned Aerial Vehicles (UAVs) and autonomous systems to perform trajectory tracking and obstacle avoidance in realtime. While many control strategies have effectively utilized linear approximations, addressing the non-linear dynamics of UAV, especially in obstacle-dense environments, remains a key challenge that requires further research. This paper intro
Manual segmentations are considered the gold standard for ground truth in machine learning applications. Such tasks are tedious and time-consuming, albeit necessary to train reliable models. In this work, we present a dataset with expert segmentations of the prostatic zones and urethra for 200 randomly selected patients from the PROSTATEx dataset. Notably, independent duplicate segmentations were
Opus 106b. Composition: Alexander von Zemlinsky. Lyrics by Ferdinand Gregorovius, Constance Bache. A version of this work already exists for soprano and chamber orchestra, but I have adapted it for soprano and string quartet.
Background: Fentanyl is commonly administered for procedural pain management in preterm infants, but target concentrations have not yet been defined. Methods: To investigate pharmacokinetics (PK), -dynamics (PD), and -genetics (PG), 25 infants (gestational age 23.3–34.1 weeks) received a fentanyl dose before a skin-breaking procedure (0.5 µg/kg) or tracheal intubation (2 µg/kg). Four pain scales w
The National Institute on Aging and the Alzheimer's Association convened three separate work groups in 2011 and single work groups in 2012 and 2018 to create recommendations for the diagnosis and characterization of Alzheimer's disease (AD). The present document updates the 2018 research framework in response to several recent developments. Defining diseases biologically, rather than based on synd
The age-standardized prevalence of Parkinson's disease (PD) has increased substantially over the years and is expected to increase further. This emphasizes the need to identify modifiable risk factors of PD, which could form a logical entry point for the prevention of PD. The World Health Organization (WHO) has recommended reducing exposure to specific environmental factors that have been reported
We report the first large-scale retrospective cohort study on adolescent and young adult (AYA) polycythemia vera (PV) and essential thrombocythemia (ET) in Japan, a subgroup analysis using Japanese multicenter registry data (JSH-MPN-R18). This study included patients with PV (n = 31) or ET (n = 141) aged 20 to 39 years at the initial visit. Hemorrhage-free survival (HFS) was better in AYA ET than
Navigation performance in urban and large-scale built-up spaces (e.g. airports, train-stations, hospitals) depends on gradual environmental perception during locomotion, and spatial knowledge acquisition, update/integration at different times along a path. Rotational locomotion is regularly involved in everyday navigation; this, combined with the fact that people cannot perceive the whole of a lar
We have previously performed empirical valence bond calculations of the kinetic activation barriers, Δ G‡calc, for the deprotonation of complexes between TIM and the whole substrate glyceraldehyde-3-phosphate (GAP, Kulkarni et al. J. Am. Chem. Soc. 2017 , 139 , 10514 - 10525 ). We now extend this work to also study the deprotonation of the substrate pieces glycolaldehyde (GA) and GA·HPi [HPi = pho
BackgroundResearch is limited on registered healthcare professionals (RHCP) usage of research and evidence-based practice (EBP) in Swedish municipal primary healthcare work.Aim/ObjectivesThe aim of this study was to increase the understanding of experiences, attitudes, and conditions of usage of research and implementation of EBP among RHCPs in a Swedish municipality setting. Further, the study ai
This report summarises the results from an interview and literature study carried out to identify key individual qualities for collective problem-solving in a fire and rescue service context. The report contributes to the research project FIRE21 (Fire and Rescue Services in the 21st Century) and is part of a work package looking into such individual qualities through using different methods and ma
Background: The Organ Care System and Non-ischemic Heart Preservation methods have emerged as significant advancements in heart transplantation, designed to mitigate ischemic injury and extend preservation times. However, their high costs and logistical complexities necessitate strategic utilization. Methods: We evaluated data from 83,761 heart transplants registered in the International Society f
A high spatiotemporal resolution technique for instantaneous flow field measurement has been developed, enabling one-dimensional velocimetry and flow field visualization within a converging–diverging nozzle. By employing femtosecond laser-induced long-lived, high-intensity plasma emission in a CO2/N2 gas flow, coupled with an ICCD camera, we achieved instantaneous one-dimensional velocity measurem
