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IMPORTANCE: The availability of behavior therapy for individuals with Tourette syndrome (TS) and chronic tic disorder (CTD) is limited.OBJECTIVE: To determine the efficacy and cost-effectiveness of internet-delivered exposure and response prevention (ERP) for children and adolescents with TS or CTD.DESIGN, SETTING, AND PARTICIPANTS: This single-masked, parallel group, superiority randomized clinic
There is substantial genetic predisposition to bladder cancer (BC). Recently, blood pressure (BP) was positively associated with BC risk in men, but the potential interaction with genetic susceptibility for BC is unknown. We investigated a weighted genetic risk score (wGRS) of 18 BC genetic variants, BP, and their interaction, in relation to incident urothelial cancer (UC, n = 385) risk in 10,576
Galectin-3 is a carbohydrate-binding protein central to regulating mechanisms of diseases such as fibrosis, cancer, metabolic, inflammatory, and heart disease. We recently found a high affinity (nM) thiodigalactoside GB0139 which currently is in clinical development (PhIIb) as an inhaled treatment of idiopathic pulmonary fibrosis. To enable treatment of systemically galectin-3 driven disease, we h
Background: Traumatic peripheral nerve injury is common and incurs significant cost to individuals and society. Healing following direct nerve repair or repair with autograft is slow and can be incomplete. Several bioengineered nerve wraps or devices have become available as an alternative to direct repair or autologous nerve graft. Nerve wraps attempt to reduce axonal escape across a direct repai
Environmental and urbanization challenges during the last few decades encouraged steady growth of mass timber construction where attention is drawn to cross laminated timber (CLT) as one of the most interesting products in terms of mechanical properties, versatility, efficient prefabrication and sustainability. Standardisation and codification regarding testing and design of CLT elements are hence
Background: In the past decades, the incidence of obesity has increased worldwide. This disease is often accompanied with several comorbidities and therefore, surgeons and anesthesiologists should be prepared to provide optimal management for these patients. The aim of this descriptive cross-sectional study was to map the criteria and routines that are used by Swedish knee arthroplasty surgeons to
The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary artery disease (CAD) comprising 181,522 cases among 1,165,690 participants of predominantly European ancestry. We detected 241 associations, including 30 new loci. Cross-ancestry meta-analysis with a
In order to systematize and rationalize the quality control process for FDS (Fire Dynamics Simulator) input data a software application for this specific purpose has been developed. In order to study the occurrence of user related errors in FDS input data and the possibility of reducing such errors by using the developed application, a case study on archived FDS input data from actual building pro
Variability of atmospheric circulation is considered one of the most important factors causing interannual and interdecadal variability of freshwater amount that is discharged from the continents. Here it is presented an analysis of the relations between the discharge variability of five major rivers in the Mediterranean basin (i.e. Adige, Arno Ebro, Po and Rhone) responsible for the 70% of total
The master thesis seeks to develop a control system for the Crazyflie 2.0 unmanned aerial vehicle to enable aggressive and autonomous flight. For this purpose, different rigid-body models are considered, differing primarily in their parametrisation of rotation. The property of differential flatness is explored and several means of parametrising trajectories in at output space are implemented. A ne
Development of valuable products from downstream process residual biomasses and profound reduction of waste are two key components for developing a more sustainable process industry. The importance of bio-renewable feedstocks and bio-based processing techniques are also crucial in the transformation to a more sustainable and green society. Therefore focus is directed on full exploitation of seawee
Utmaningar kring samarbete och effektivt utnyttjande av den tvärprofessionella kompetensen har observerats i svenska elevhälsoteam. En kommun har adresserat dessa svårigheter genom att implementera ett gemensamt ramverk, Systematiskt Tillsammans för Lärande (STfL). Syftet med föreliggande studie var att utforska hur ett sådant gemensamt ramverk upplevs av elevhälsoteamens olika professioner vad gäCollaboration and efficient use of multidisciplinary competence has been observed to be difficult in student health teams (SHT) in Sweden. One municipality has addressed these issues by implementing a common framework, Systematically Together for Learning (STfL). The aim of this study was to explore how this framework was experienced by the student health service professionals in relation to imple
Personer som innehar statlig anställning är på ett sätt som vilka arbetstagare som helst. PÅ ett annat sätt så är dem representanter för staten och deras ageranden påverkar allmänhetens uppfattning och tilltro till staten och dess myndigheter. Därför har man under perioder särskilt denna arbetstagargrupp från övriga arbetstagare då det har gällt striktare regler vid fel begångna i sin tjänsteutövnPeople who hold government employments are in a way like any other workers. In another way, they are representatives of the state and their actions affect the public's perception and trust in the state and its authorities. Therefore, during periods, this group of workers in particular has been separated from other workers and stricter rules have applied in the event of errors committed in the
Practitioners primarily utilise nonparametric methods when estimating Value-at- Risk (VaR) and Expected Shortfall (ES) for computing capital requirements. However, various researchers assert that there are issues with those estimates, particularly amidst periods of market turmoil. Academia produces novel parametric methods to estimate extreme risk measures to address these deficiencies. Neverthele
The purpose of this study is to conduct the Life Cycle Assessment of IKEA’s two Sofa products and provide recommendations for reducing the overall carbon footprints. Different phases of supply chains are included in the scope of this study, i.e., selection of raw materials, their acquisition, production phase, and transportation of final product to market regions. The benefit of the study is that
The mycelium enables a fungus to explore and interact with spatially and temporally heterogenous environments. It operates at a range of scales, with hyphal traits and cellular events affecting network and colony behavior. Recently, the fungal mycelium has also been used to produce new, sustainable biomaterials which can serve as alternatives to numerous non-renewable or polluting materials and pr
This thesis proposes a fully integrated transformer-coupled active power and antenna impedance detector for WLAN 802.11ax 5 and 6 GHz frequency bands. The detector is integrated into a transceiver, utilising the receive chain to down convert sensed RF voltage and current and digitally calculate the active power and antenna impedance on-chip. The RF current measurement is realized by a sense windin
Humanitarian Crisis is an alarming problem throughout the world. Bangladesh also is undergoing Rohingya refugee crisis with grave severity and challenges. Over 1 million Rohingya people have been settled over the top of hills, living without inadequate WASH facilities. This study tried to analyse the humanitarian crisis by Pressures-States-Responses framework depicting the factors exacerbating the
