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Background: Implementing the evidence-based Individual Placement and Support (IPS) model in welfare states like Sweden faces contextual challenges that often necessitate local adaptations to enhance fit and effectiveness. While fidelity assessments aim to ensure effective outcomes, adaptations may lead to unintended drift from core components. The Model for Adaptation Design and Impact (MADI) help
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A combination treatment (CT) of proinsulin and IL-10 orally delivered via genetically modified Lactococcus lactis bacteria combined with low-dose anti-CD3 (aCD3) therapy successfully restores glucose homeostasis in newly diagnosed non-obese diabetic (NOD) mice. Tolerance is accompanied by the accumulation of Foxp3+ regulatory T cells (Tregs) in the pancreas. To test the potential of this therapy o
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OBJECTIVE: To evaluate a system for delivery of inhaled nitric oxide.DESIGN: Prospective, laboratory study.SETTING: Engineering laboratory.SUBJECTS: A standard ventilator (Servo Ventilator 300), supplemented with extra gas modules for nitric oxide delivery.INTERVENTIONS: Two ventilator-integrated gas modules, delivering < or = 10 parts per million (ppm) or < or = 100 ppm of nitric oxide, were used
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We report the first detailed chemical, microstructural and thermal analyses of a growing corpus of metallurgical tuyeres from the wider archaeological landscape of Great Zimbabwe in southern Africa. Of note is the fusion of the tuyeres in multiples, suggestive of widespread use of natural draft iron smelting technologies for large-scale production of iron most likely during the zenith period of Gr