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Domain swapping as a molecular mechanism in amyloidosis

Popular Abstract in Swedish Som en blixt från klar himmel drabbas en ung, och till synes frisk person, av hjärnblödning. Denna stroke leder till demens och efterföljande nya blödningar leder slutligen till en för tidig död. Man har kunnat visa att denna sjukdom beror på att en variant av ett visst protein, cystatin C, tvinnar ihop sig till rep-liknande långa fibriller. Dessa fibriller ansamlas sedAmyloidosis is a group of diseases characterized by a change in protein conformation resulting in aggregation and tissue deposition of amyloid fibrils. One variant of cystatin C, L68Q cystatin C, is highly amyloidogenic and persons carrying the corresponding gene suffer from massive cerebral amyloidosis leading to brain hemorrhage and death. Amyloidogenic proteins like cystatin C and prion protein

Portfolio Selection and the Analysis of Risk and Time Diversification

Popular Abstract in Swedish Denna avhandling behandlar tre centrala områden i finansiell ekonomi i allmänhet och portföljvalsteori i synnerhet: riskmåttet, estimeringsrisk och tidsdiversifiering. Avhandlingen består av fem kapitel varav ett är ett kort introduktionskapitel. De första två kapitlen behandlar ett alternativt mått på risk, lower partial moment (LPM). Detta alternativa mått behandlar eThis thesis is devoted to the analysis of three important issues in financial economics in general and portfolio selection in particular: the risk measure, estimation risk and time diversification. Besides a short introductory chapter the thesis consists of four empirical essays. In the second chapter, the effect of estimation risk on the efficient frontier in the lower partial moment framework is

Mechanisms of Transgene Silencing in Neural Cells -Implications for Ex Vivo Gene Therapy to the Brain

The use of genetically modifi ed neural stem and progenitor cells could possibly be a future strategy for repairing a brain suffering from neurodegeneration. However, so far it has proven diffi cult to maintain sufficient levels of a transferred gene in suitable cell types, after transplantation. In the present thesis I studied the silencing of transgenes induced upon differentiation of neural pro

Understanding environmental performance variation in manufacturing companies

Purpose: Sustainability is an area of increasing interest for industry and its stakeholders, and some companies now aspire to address sustainability issues (e.g. carbon emissions) at strategic and operational levels. As companies are exploring the issues, they attempt to embed sustainability in their planning and management systems. It is at this point that the domains of environmental concern and

A robust Multi-Band Water Index (MBWI) for automated extraction of surface water from Landsat 8 OLI imagery

Surface water is vital resources for terrestrial life, while the rapid development of urbanization results in diverse changes in sizes, amounts, and quality of surface water. To accurately extract surface water from remote sensing imagery is very important for water environment conservations and water resource management. In this study, a new Multi-Band Water Index (MBWI) for Landsat 8 Operational

Impact of Surgery for Primary Hyperparathyroidism

Primär hyperparathyroidism, pHPT, är en relativt vanlig endokrinologisk sjukdom som karaktäriseras av förhöjd utsöndring av bisköldkörtelhormon, PTH, i förhållande till kalciumnivån i blodet. Sjukdomen är vanligast hos äldre och kvinnor, och orsakas oftast av en godartad tumör i en bisköldkörtel (80–85% av fallen) eller mer diffus förstoring av flera bisköldkörtlar. Bisköldkörtlarnas fysiologiska

Science with the Cherenkov Telescope Array

The Cherenkov Telescope Array (CTA), will be the major global observatoryfor very high-energy (VHE) gamma-ray astronomy over the next decadeand beyond. The scientific potential of CTA is extremely broad: fromunderstanding the role of relativistic cosmic particles to the search for darkmatter. CTA is an explorer of the extreme universe, probing environmentsfrom the immediate neighbourhood of black

Half-sandwich Metal Complexes with Salicylaldimine Ligands and Tricarbonyl Metal Complexes with Pyridinmethanimine Ligands

Malaria är en sjukdom som orsakas av parasiter av plasmodium släktet och överförs mellan människor av myggor. Då myggan biter en malariasmittad människa och förtär dess blod så innehåller detta blod parasiter som i senare sprids ifrån myggans mage och vidare till dess salivkörtlar. När myggan vid ett senare tillfälle biter en frisk människa, överförs parasiten från salivkörtlarna till människans bMalaria is a massive global health crisis that is most prevalent in tropical regions of Africa, Asia, and Latin America. The World Health Organization (WHO) estimated in 2013 that 3.3 billion people were at risk of being infected by the disease, resulting in around 200 million cases with more than 500 000 of these cases leading to lethal outcome. Africa was by far the most affected by the disease

Ny marknadsmissbruksförordning - ny insiderreglering?

En fungerande kapitalmarknad är en förutsättning för ett växande näringsliv. För att upprätthålla en fungerande kapitalmarknad med jämlika spelregler för alla aktörer finns marknadsmissbruksreglerna. Ett särskilt marknadsmissbruk som anses hota kapitalmarknadens funktionalitet är insiderhandel. Under 2000-talet har det skett en snabb teknisk utveckling vilket medfört betydande förändringar av den A properly functioning capital market is a necessary condition for a growing economy. In order to maintain a functioning capital market there are regulations against market abuse. A special kind of market abuse that is considered to threat the functionality of the capital market is insider trading. Due to the rapid technical development during the 21st century there has been major changes in the f

Har konsumtionen av rött kött förändrats i svenska grundskolor de senaste åren?

Pupils have gotten school meals in Sweden since the late 1800´s. The school meal has of course changed over the years. In the beginning the pupils only got porridge and milk. Since then they serve both meat-, fish- and chicken dishes. In recent years, many schools around the country are more concerned about the environment and therefore started to serve more plant-based diets and less red meat. Re

Obsolescence Management of Electronics - A multiple case study based on the automotive industry

Background Lifecycles of electronics are decreasing, whereas companies with long life product such as the automotive and defence industry is increasing electrification in their products. Consequently, the mismatch in lifecycles between the electronics industry and Original Equipment Manufacturers (OEMs), with long life products, requires a solid obsolescence management process, to mitigate and res

Functional analysis of cultured retinal cells

Undersökning av näthinneceller odlade på ljuskänsliga nanotrådar Människans sinnen bombarderas ständigt med nya intryck. En stor del av dessa förmedlas via vår syn. Ljus kommer in i ögat och absorberas av ljuskänsliga fotopigment som finns i de yttre segmenten av näthinnans fotoreceptorer. Näthinnan är uppbyggd av flera olika skikt och av flera olika celltyper, både nervceller och stödjande gliacWorldwide, millions of people suffer from retinal degenerative diseases leading to cell death of light absorbing photoreceptors. This results in vision impairment and, in many cases, eventually blindness. A possible solution for patients gone legally blind due to retinal degeneration, is the use of retinal implants. The best performing retinal implants of today, regarding vision acuity, still give

“IF WE HAVE THE SEX PURCHASE LAW, WE MUST BE PREPARED TO HELP” - How some of Sweden’s social services work with youths having sex for compensation

This thesis aims to look into how some social workers in Sweden view their work with youths having sex for compensation with regards to the feminist ideas that the law on buying sex expresses. Swedish studies have shown that most of the youths having sex for compensation started when they were 13-14 years old. Previous literature and studies state that youths having sex for compensation often have

A Week in Melbourne with Christoph Turatus

G'day mate! Hej from the other side of the world! While your day has just started, another day in Australia is about to end (8-10 h time difference). Since July, I have been on exchange in beautiful and vibrant Melbourne.   Let me introduce myself  QUICKLY:  I'm Christoph and currently in my second year of M.Sc. Strategic Communication. In the third semester, we have the option between taking elec

https://www.isk.lu.se/en/week-melbourne-christoph-turatus - 2026-05-15

Bosch pau

Introduction LUMES Master’s Thesis 2002 Benefits and Opportunities of increasing the Building Potential of Brownfields in the Metropolitan Area of Barcelona A case study of the city of Barcelona Pau Bosch Architect Joaquim Vayreda 49, 2-2 17001 Girona, Spain Tel: +34972207190 fax: +34972207190 pau.bosch.916@student.lu.se Supervisor Hördur Haraldsson Chemical Engineering Biogeochemistry Lund Instit

https://www.lumes.lu.se/sites/lumes.lu.se/files/bosch_pau.pdf - 2026-05-17

Methods of Multi-Conjugate Adaptive Optics for Astronomy

Popular Abstract in Swedish Multikonjugerad Adaptiv Optik för Astronomiska Teleskop 1. Atmosfärisk turbulens Allt sedan man på 1600-talet började bruka optiska instrument inom astronomin, för att understödja det mänskliga ögat då man beskådade stjärnhimlen, har astronomer strävat efter att bygga allt större och bättre teleskop för att kunna se längre ut i rymden och skönja allt ljussvagare objekt.This work analyses several aspects of multi-conjugate adaptive optics (MCAO) for astronomy. The research ranges from fundamental and technical studies for present-day MCAO projects, to feasibility studies of high-order MCAO instruments for the extremely large telescopes (ELTs) of the future. The first part is an introductory exposition on atmospheric turbulence, adaptive optics (AO) and MCAO, esta

Combined chemotherapy and immunotherapy against experimental malignant brain tumors

Popular Abstract in Swedish Trots ett sunt leverne med regelbunden motion och nyttig mat kan vi inte alltid förhindra risken att drabbas av vissa typer av cancer som till exempel hjärntumörer. Den vanligaste formen av elakartade hjärntumörer heter glioblastoma multiforme och är också den mest aggressiva. Symptomen varierar beroende på tumörens storlek och var i hjärnan den växer, och patienter kanGlioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor in adults. Despite standard treatment including surgery, radiotherapy and temozolomide (TMZ)-based chemotherapy, the prognosis for GBM patients is dismal, and there is a need for novel treatments. One possible therapeutic treatment modality presented here is immunotherapy, either alone or combined with in

Impact of Lifestyle, Hormones, and Genes on Breast Cancer

Popular Abstract in Swedish Bröstcancer är den vanligaste cancerformen hos kvinnor i Sverige. Årligen drabbas 7000 kvinnor i Sverige och cirka 1500 kvinnor dör av sin sjukdom. Bröstcancer uppkommer genom ett samspel mellan livsstil, miljö och gener. En kvinna som har en förstagradssläkting (t.ex. syster, mor) med bröstcancer har ungefär dubbelt så stor risk att drabbas av bröstcancer jämfört med eApproximately 7000 women are diagnosed and 1500 women die from breast cancer in Sweden every year. The aim of this thesis was to study the interplay of polymorphisms, hormone levels, lifestyle, and the use of concomitant medication in relation to risk and prognosis in two cohorts: one composed of young healthy women from high-risk breast cancer families and the other of breast cancer patients fro

Effective secondary fracture prevention: implementation of a global benchmarking of clinical quality using the IOF Capture the FractureA (R) Best Practice Framework tool

Fracture Liaison Services are the best model to prevent secondary fractures. The International Osteoporosis Foundation developed a Best Practice Framework to provide a quality benchmark. After a year of implementation, we confirmed that a single framework with set criteria is able to benchmark services across healthcare systems worldwide. Introduction Despite evidence for the clinical effectivenes

Language impairment in Swedish bilingual children - epidemiological and linguistic studies

Popular Abstract in Swedish Det svenska samhället har förändrats mycket genom invandring under de senaste årtiondena. Många barn i Sverige har idag ett annat modersmål än svenska. De flesta barn tillägnar sig svenska utan problem, medan så inte är fallet för vissa barn. Dessa skillnader har diskuterats, och olika förklaringar till detta har framhållits, till exempel bristfällig exponering för svenThe aim of this thesis was to provide both epidemiological and linguistic data on bilingual children with language impairment (LI), since few data on this group exist. Data from 438 bilingual and monolingual children, referred over a period of 12 months, were compared in the first epidemiological study. The results showed that the bilingual children with suspected LI were referred significantly l