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Autoantibodies against glutamic acid decarboxylase 65 (GADA) are found frequently in patients with autoimmune diabetes. Immunoglobulin (Ig)G(1) is the most frequent subclass among the GADA IgG subclasses. IgG(4) is a more common subclass in latent autoimmune diabetes in adults (LADA) at clinical onset compared to type 1 diabetes. The aim of this work was to study the different GADA-IgG subclass pr
During the influenza pandemic 2009-2010, an AS03- adjuvanted A(H1N1)pdm09 vaccine was used extensively in children 6 months of age and older, and during the 2010-2011 influenza season, the A(H1N1)pdm09 strain was included in the seasonal trivalent inactivated influenza vaccine (TIV) without adjuvant. We evaluated the immunogenicity and safety of TIV in children previously vaccinated with the AS03-
PICT (Pollution Induced Community Tolerance) to Cu is a useful and sensitive tool to assess the effects of Cu pollution in soils under laboratory conditions. However, in field situations, the absence of reference values, i.e. bacterial community tolerance to Cu baseline from non-polluted soils, make the method uncertain when we want to know if a soil is or is not polluted from a microbiological po
Purpose: Getting an incurable oesophageal or gastric cancer diagnosis is a major stressful life event associated with severe physical, psychosocial and existential challenges. To provide timely and efficient support, based on patients' experiences, the aim of the study was to explore how patients newly diagnosed with incurable oesophageal and gastric cancer manage everyday life. Method: Semi-struc
Despite the desire to utilize proactive safety metrics, research results indicate imbalances can arise between economic performance metrics and safety metrics. Imbalances can arise, first, because there are fewer proactive metrics available relative to the data an organization can compile to build reactive metrics. Second, there are a number of factors that lead organizations to discount proactive
Intensity Analysis (IA) of land use and land cover change (LULCC) is important to support policy and practice. We applied IA to analyse LULCC in Sironko catchment, Uganda. Results show that agricultural land, forest, and wetland reduced by 8%; 32%; and 20% between 1986-2000. Between 2000-2016, forest, wetland, and built-up areas increased by 84%, 5%, and 57%. Active gainers between 1986-2000 were
We investigate how selection of psychiatric cases by phenotypic criteria can alter the strength and specificity of their genetic risk by examining samples from national Swedish registries for five disorders: major depression (MD, N = 158,557), drug use disorder (DUD, N = 69,841), bipolar disorder (BD, N = 13,530)) ADHD (N = 54,996) and schizophrenia (N = 11,227)). We maximized the family genetic r
Introduction: Contact allergy to nickel (Ni) is a delayed-type hypersensitivity reaction mediated by Ni-reactive T cells producing the hallmark cytokines of several T-helper cell (Th) populations including IFN-γ(Th1), IL-4, IL-5 and IL-13 (Th2), and IL-17A (Th17). IL-22-expressing CD4+ cells, which could be either Th17 co-expressing IL-22 or Th22, expressing IL-22 in the absence of IL-17A, have al
PurposeZinc has been suggested to be protective against breast cancer, but the evidence remains inconclusive. One reason for inconsistent findings in previous studies may be that zinc only influences the risk of developing certain subtypes of breast cancer. Our study is the first study assessing zinc levels in relation to the risk of different breast cancer subgroups, defined by their tumor charac
IntroductionBeta-lactam antibiotics are essential in the treatment of Gram-negative bloodstream infections. The effect of beta-lactam antibiotics depends on the time of unbound antibiotic concentration above the minimal inhibitory concentration (MIC). An antibiotic concentration above MIC during the whole dosing interval (100% ƒT > MIC) has been suggested as a target for severe infections. The aim
Background: Opioid substitution treatment (OST) populations are aging and have increased mortality and somatic morbidity compared to general populations internationally. While OST patients have poor self-rated physical health and unmet healthcare needs, documented healthcare utilization has been sparsely investigated. The aim of this study was to assess registered healthcare utilization for somati
There is a vast global market of information and communication technologies to be used for educational purposes (ICT4E), both inside and beyond formal schooling. Both the products on offer and the large bulk of academic literature and strategic documents concerned with ICT4E tend to look at these technologies as providing simple technical solutions to complex educational problems. Moreover, the ut
Engelsk titel: Greater opportunities than interests : Civic culture and deliberative discourse on Swedish NGO websites This is a critical and normative study, which examines a selection of Swedish NGO websites as potential forums for civic culture and deliberative discourse in the public sphere. Sociocultural, political and sociological and media and communication theories are combined. The work
The aim of the study is to find a relation between the tip pressure produced by ram sounding and CPT in order to improve the possibilities of determining the shear strength of clay till. CPT is a pressure probe and mainly used to get a good picture of the statigraphy and the soil condition. CPT has shown to be useful regarding the evaluation of key parameters such as shear strengh and angle of fri
Today the Unified Glare Rating (UGR) tabular method according to CIE 117-195 and CIE 190-210 is practically the only one used for evaluation of discomfort glare in the lighting design process but it is unknown if the method is in line with the subjective perception of glare (SGI). We investigated whether UGR calculation method currently used in lighting design is in agreement with the perceived di
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https://www.keg.lu.se/sites/keg.lu.se/files/heka12_2_schema_vt_2017.pdf - 2026-07-07
