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The present study examines the capacity of fetal neocortical grafts placed in a brain infarct to exchange axonal projections with the host brain. Five to 7 days after a middle cerebral artery occlusion in adult spontaneously hypertensive rats, dissociated neocortical primordium from fetuses of gestational age 15-16 days was implanted into the infarcted area. Four to 11 months later, the neural tra

Archaeologists seek to analyze patterns of similarity and difference among diverse kinds of assemblages that (1) vary in the number of specimens and (2) have been characterized by standard multi-category frequency distributions. Recent developments in computer simulation methods offer marked improvements in our ability to test statistical hypotheses about variation in relative taxonomic or typolog

Administration of oligodeoxynucleotides (ODNs) containing CpG motifs generates a rapid and potent response of CC-chemokines, known as ligands of the HIV-1 co-receptor CCR5, in the murine female genital tract. The present study explored the potential HIV inhibitory activities of different human CpG prototypes either alone or conjugated to the non-toxic subunit of cholera toxin (CTB). Results showed

A transgenic mouse model of Huntington's disease (R6/1 and R6/2 lines) expressing exon 1 of the HD gene with 115-150 CAG repeats resisted striatal damage following injection of quinolinic acid and other neurotoxins. We examined whether excitotoxin resistance characterizes mice with mutant huntingtin transgenes. In a new transgenic mouse with 3 kb of mutant human huntingtin cDNA with 18, 46, or 100

Aim/hypothesis Hyperinsulinaemia maintains euglycaemia in insulin-resistant states. The precise cellular mechanisms by which the beta cells adapt are still unresolved. A peripherally derived cue, such as increased circulating fatty acids, may instruct the beta cell to initiate an adaptive programme to maintain glucose homeostasis. When this fails, type 2 diabetes ensues. Because mitochondria play

l-DOPA-induced motor complications can be modelled in rats with 6-hydroxydopamine (6-OHDA) lesions by chronic injections of l-DOPA. We have compared the sensitisation and duration of rotational responses, and the occurrence of dose–failure episodes and abnormal involuntary movements (AIMs) in 6-OHDA-lesioned rats with regard to the dose and route of administration of l-DOPA. Rats were treated with

The Svecofennian orogen in the Fennosandian Shield consists of several Palaeoproterozoic meta-igneous provinces that generally young progressively southwards and westwards. The understanding of the tectonic evolution of these different provinces is linked to the ability to constrain the timing of ductile deformation and metamorphism within them. In the western part of the orogen, in central Sweden

An outbreak of suspected contact dermatitis among subway construction workers was suspected to be due to a new bisphenol A/F-based epoxy resin system (ERS). The construction workers used ERSs during the insertion of iron bars into concrete walls. The objective of the study was to determine the components (if any) of the ERS responsible for the contact allergy. Patch testing was performed on 20 of

Purpose: To prospectively test the mathematical models for calculation of the risk of malignancy in adnexal masses that were developed on the International Ovarian Tumor Analysis (IOTA) phase 1 data set on a new data set and to compare their performance with that of pattern recognition, our standard method. Methods: Three IOTA centers included 507 new patients who all underwent a transvaginal ultr

In studies of the effects of different training programmes, one muscle--most commonly the vastus lateralis--is used for the experiment while the contralateral muscle serves as a control, at the same time as muscle biopsies are taken from both sides. In order to increase the reliability of such studies, the sources and the magnitude of the sampling errors in the biopsy techniques need to be assesse

Asexuals come in all sorts. In this personal overview, I identify asexual organisms with eukaryotes that do not regularly go through the meiotic cycle. Such organisms may be asexual in many different ways and of many different reasons. The spread of asexuality is therefore always a unique process, and any notion of a general evolutionary advantage for asexuality is at best misleading. In discussio

Popular Abstract in Swedish Den här avhandlingen studerar olika statistiska metoder för att utvinna information som ligger dold i en serie av tal eller andra symboler, exempelvis bokstäver. En sådan serie kan innehålla slumpmässighet eller ha vissa mätbara statistiska egenskaper, men har även ett inneboende mönster, vilket vi är intresserade av. Vi kallar vanligtvis sådana serier för signaler, ochThis thesis examines sparse statistical modeling on a range of applications in audio modeling, audio localizations, DNA sequencing, and spectroscopy. In the examined cases, the resulting estimation problems are computationally cumbersome, both as one often suffers from a lack of model order knowledge for this form of problems, but also due to the high dimensionality of the parameter spaces, which

One of Scanias earliest castles, Grevlunda, has been reinvestigated. The first excavation in 1913 gave an interesting result but the time was not ripe for understanding what really was found. In 2002 archaeologists in corporation with historians, and culture geographers found out that the Grevlunda was a motte of a rare construction. The pottery material gave a dating to the late 12:th century. Th