Sökresultat

Popular Abstract in Swedish Blodet består av olika typer av celler med olika funktioner. De röda blodkropparna transporterar syre till alla delar av kroppen, blodplättar stoppar blödningar och en rad olika vita blodkroppar försvarar oss från olika typer av angrepp från till exempel virus eller bakterier. Generellt för alla dessa olika typer av celler är att de är kortlivade och måste ersättas kontMature blood cells are crucial for life, but they have a short lifetime and thus have to be replaced. These mature blood cells are produced by lineage restricted progenitors, which themselves are generated by rare multipotent hematopoietic stem cells (HSCs) in a highly dynamic process called hematopoiesis. In addition to the ability of HSCs to generate all blood cell lineages, they possess the uni

Popular Abstract in Swedish En ny metod för tillförsel av läkemedel, samt för koncentrationsmätning av olika kroppsegna och främmande ämnen i ögat. Populärvetenskaplig sammanfattning Vi har anpassat den sk mikrodialystekniken för intraokulärt bruk (dvs för ögon) på kaniner. Tekniken utvecklades ursprungligen vid Karolinska Institutet, Stockholm, för mätning av signalsubstanser i hjärnan. Den bygThe method of microdialysis has been adapted for ocular use. It is a technique for monitoring concentrations of different molecules in a tissue in vivo. It is based on the principle of diffusion through a semipermeable membrane. The membrane is mounted on a soft plastic shaft, connected to an inlet and an outlet tube. The whole device, called microdialysis probe, was implanted into the vitreous bo

Solar electricity is one of the most promising technologies for our future electricity supply. By using concentrators, it is possible to reduce the cost of generating photovoltaic electricity. This thesis discusses how to design stationary low concentrating systems for photovoltaic or PV/Thermal applications. The first chapters briefly explain the optics of solar energy concentrators. The theoreti

Popular Abstract in Swedish Vårt immunförsvar arbetar konstant med att skydda kroppen från olika föremål, t. ex. bakterier, virus, gifter och cancertumörer, som kan orsaka skada eller sjukdom. För att kunna försvara kroppen mot sådana föremål så har immunförsvaret tillgång till flera, oerhört effektiva, vapen. Det viktigt att immunförsvaret känner igen, och endast angriper, skadliga föremål, så atCD40 is a cell surface receptor of pivotal importance that is expressed on several of the cells in the immune system. It is critical for many important events, such as T cell dependent B cell activation, isotype switching, somatic mutation and generation of B cell memory. The central role of CD40 in the immune system makes it an ideal target for antibody based immunotherapy. This led us to charact

The necessity of a canon had been restated, but literature, meanwhile, had lost a good share of its public. The self-referential syndrome evolved into an epidemic: there was a problem of reader-response approach at that moment. The public shrank and the cultural world became endogamous. This meant that a large part of the public was actually made of writers who craved for climbing the literary lad

Macroporous hydrogels are regarded as interesting materials both within biotechnology and biomedicine due to their properties. These materials can be prepared from a wide range of synthetic or naturally occurring compounds using a number of different techniques for their production. For this thesis, cryostructuring was used to prepare macroporous hydrogels, often named cryogels. The work utilized

Background: Type 2 diabetes, chronic kidney disease (CKD) and its cardiovascular complications are increasing as health problems worldwide. These diseases are interrelated with overlapping occurrence and once diabetes is established, the risk of cardiorenal disease is dramatically elevated. Thus, a search for unifying modifiable risk factors is key for effective prevention. Summary: Elevated fasti

The thesis describes the use of molecular motors in nanofabricated devices designed for potential applications in biosensing, computation and detection. We utilize the well-established guiding principles for controlling the motion of actin filaments propelled by myosin molecular motors, and build upon these developments in order to improve upon previously demonstrated techniques, and establish new

We recently described a method to compute accurate quantum mechanical free energies [Rod, T. H.; Ryde, U. Phys. Rev. Lett. 2005, 94, `138302]. The method, which we term quantum mechanical thermodynamic cycle perturbation (QTCP), employs a molecular mechanics force field to sample phase space and, subsequently, a thermodynamic cycle to estimate QM/MM free energy changes. Here, we discuss the method

Popular Abstract in Swedish Arbetet avser studier av regnkarakteristik i tid och rum i Kuala Lumpur, Malaysia. I storskalig betraktelse studerades ett 550 km2 område för att bl.a. finna påverkan av monsuner. I skalan av ett avrinningsområde avsåg arbetet en studie av regnets dynamiska egenskaper och rumsliga korrelationsstrukturer. I en enpunktskala, för ett 23 km2 stort område framtogs sannolikheRainfall characteristics of Kuala Lumpur, Malaysia, are studied in space and time; on a large scale, 550 km2, and long term scale to find out the monsoon influence, and on urban basin scale, 23 km2, to determine dynamic properties of rainfalls and spatial correlations, and on a point scale to determine the probabilities of very high rain intensities. The importance of spatial and temporal variabi

Experiments were performed to define quantitatively the substrate (K(+) and Cl(-)) dependence of the transport function (production of equally large and oppositely directed K(+)and Cl(-) flows/currents) of an earlier (Theander et al., 1999) identified electroneutral K-Cl cotransporter in the slowly adapting stretch receptor neurone of the European lobster. The experiments were based on microelectr

The thesis includes five separate studies concerned mainly with psychosocial aspects of the problems that athletes afflicted with long-term sport injuries face. The first study deals with relationships between personality variables, coping strategies and mood-levels, both in athletes participating in competitive sports and in a non-athlete reference groups. The results indicate the athletes to us

Popular Abstract in Swedish Det råder delade meningar om hur man bäst tar hand om patienter med lindrig primär hyperparatyreoidism (PHPT), dvs. överfunktion i en eller flera av de fyra bisköldkörtlarna med endast lätt förhöjning av kalciumnivån i blodet. Det finns de som förordar operation, medan andra anser att det inte behövs någon behandling så länge sjukdomen inte förvärras. Syftet med det aktThere is an ongoing controversy regarding how to take care of patients with mild primary hyperparathyroidism (PHPT). Some recommend surgical treatment at diagnosis, others just follow-up as long as there is no evidence of disease progression. The aim of this thesis was to evaluate cardiac and skeletal risk factors related to the duration of mild PHPT. Fifty patients with mild PHPT were randomized

Popular Abstract in Swedish Arbetet i denna avhandling berör elektroniska komponenter och hur de kan användas i kretsar för trådlös kommunikation. Den huvudsakliga slutsatsen av arbetet är att innovativa och icke konventionella komponenter kan bidra till att förbättra presentanda och minska effektförbrukningen i system för kommunikation på korta avstånd. Framförallt har en krets tillverkats som geShort high-frequency electromagnetic pulses, also referred to as wavelets, are considered for use in various short-range impulse based ultra-wideband applications, such as communication, imaging, radar, spectroscopy, and localization. This thesis investigates field-effect and tunneling based semiconductor devices and their operation in millimeter-wave (mm-wave) impulse transceivers. The main resea

A new and simple method for the repair of nerve defects, in which sutures alone are used to guide regeneration between the nerve endings, was developed. Bilateral seven to 17 mm rat sciatic nerve defects were bridged by continuous longitudinal sutures with or without different modifications, by conventional autologous nerve grafts or direct repair under tension as controls. Evaluation was performe

Popular Abstract in Swedish Reumatoid artrit/ledgångsreumatism (RA) är en kronisk inflammatorisk sjukdom som i första hand drabbar lederna. Man uppskattar sjukdomens förekomst i den vuxna befolkningen till cirka en halv procent och den är 2-4 gånger vanligare hos kvinnor. Vi vet inte vad som orsakar RA, men såväl ärftliga som omgivningsfaktorer har betydelse. RA har ett varierande förlopp. Dels kaRheumatoid arthritis (RA) is characterized by persistent inflammation, progressive joint damage and disability. This thesis describes the outcome after 10 years in a cohort of 183 RA patients (116 women, 67 men) recruited 1985-89. The mean age was 51 years and symptom duration 11 months at inclusion. Standardized clinical, biochemical and radiographic assessments were performed annually. Health st

Popular Abstract in Swedish Syfte: Att studera de inter- och intramolekylära processer som sker efter excitation av en porfyrinmolekyl. De huvudsakliga pigmenten i det fotosyntetiska antennsystemet; klorofyll a, klorofyll b, samt bakterioklorofyll a är alla porfyriner, som absorberar solljus och transporterar energin till ett reaktionscenter där energin används för laddningsseparation och elektroThis thesis describes inter and intramolecular dynamics in porphyrin molecules. To create a basis for understanding the energy and electron transfer processes in photosynthesis, the ultrafast dynamics of monomeric chlorophyll a, chlorophyll b and bacteriochlorophyll a were studied with ultrashort laser pulses. The transient absorption spectra of all three molecules were found to have pronounced co

This thesis explores women’s access to property in Kenya. It consists of three parts. The first gives the Kenyan background, the theoretical and methodological approach. The second presents the findings in relation to the social construct of the gender and elaborates them in the contexts of women´s subsistence work, colonization and its aftermath and women´s formation of organizations. The third p

Popular Abstract in Swedish Köpenhamnsevangeliariet skrevs och illuminerades i England omkring år 1000, och intar en viktig position i konsthistorien genom sina ikonografiska likheter med det 300 år äldre Lindisfarneevangeliariet. I föreliggande avhandling behandlas handskriften i sin helhet med avseende på dess framställning och senare historia, men den huvudsakliga analysen rör bildernas stilistThe subject of this thesis is the Copenhagen Gospel Book , written and illuminated in England c 970 with additions from c 1020. The thesis is divided into three main parts focusing on different aspects of the manuscript. The first part deals with problems concerning provenance, palæography, later additions and the physical architecture of the manuscript. The author questions the opinion that the m