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The renin–angiotensin system (RAS), and particularly its angiotensin type-2 receptors (AT2), have been classically involved in processes of cell proliferation and maturation during development. However, the potential role of RAS in adult neurogenesis in the ventricular-subventricular zone (V-SVZ) and its aging-related alterations have not been investigated. In the present study, we analyzed the ro
This article aims to analyse how the intertwining of politics and religion, economic transformation due to industrialisation, and family influence each contributed to the abandonment of the traditional, religious marriage calendar during the eighteenth and nineteenth centuries in the Barcelona Area or the Oficialitat de Barcelona, the most populated deanery among the four that comprised the Dioces
The ability to predict the absorption of exenatide (Ex), a GLP-1 analogue, after oral dosing to rats in self-nanoemulsifying drug delivery systems (SNEDDS), using in vitro methods, was assessed. Ex was complexed with soybean phosphatidylcholine (SPC) prior to loading into SNEDDS. A design of experiments (DoE) approach was employed to develop SNEDDS incorporating medium-chain triglycerides (MCT), m
Freshwater ecosystems, being highly susceptible to the impacts of climate change, experience a greater influence than terrestrial and marine ecosystems. Hence, by identifying the regions that will be most affected by climate change in the future, managers can implement more efficient and effective measures to protect them. In this study, we utilized six Luciobarbus species residing at the southern
Deoxynivalenol (DON) is a common mycotoxin in crops that could induce intestinal inflammation, affecting the susceptibility of intestinal epithelial cells (IECs) to pathogen infection. This study aimed to investigate DON's effects on mucin and cytokine production as part of the local immune system and how it affected intestinal susceptibility to pathogen infection. Caco-2 cells were exposed to DON
Childhood stunting is a serious global public health issue that exhibits local spatial variations. Previous studies have used traditional statistical methods to identify stunting risk factors, and little is known about the application and usefulness of spatial machine learning techniques in identifying localized stunting risk factors based on complex datasets. This study assesses the performance o
Objective. To investigate the course of disability related to the upper extremities (UEs) in early rheumatoid arthritis (RA), and to assess correlations between such disability and clinical variables, including grip force. Methods. In an inception cohort of patients with early RA (diagnosed 1995-2005, N = 222, follow-up 10 yrs), disability of the UEs was assessed using a subscore of the Health Ass
[Background] The previous studies suggest that radioactive elements like Cs+and Sr may adversely affect marine ecosystems and the fishing industry. Traditional treatment systems for radioactive wastewater like the Advanced Liquid Processing System (ALPS) and Kurion have faced challenges in limiting concentration and achieving safety criteria. Studies suggest potential long-term impacts on benthic
BACKGROUND: The impact of the sustainable EAT-Lancet planetary health diet on brain and cognitive health remains unclear. This study compared the impact of the EAT-Lancet diet with the well-established cognitive-beneficial Mediterranean diet (MeDi) in relation to neuroimaging biomarkers and cognitive performance among older adults.METHODS: The study included 615 dementia-free 70-year-olds from the
This study analyzes the transition to mechanized forest management and the implementation of sustainable-yields forestry in Sweden during the 1950s and 1960s. The objective is to produce insights that are relevantfor policymakers working with forests and the climate transition today. The analysis focuses on how the Swedish National Association of Forest Owners’ Associations (SSR)—an association or
We have calculated redox potentials of 12 blue copper protein sites comparing 64 computational methods, systematically varying the quantum mechanics (QM) system size, dielectric constants, density functional, and basis sets. All methods were based on structures optimized with combined QM and molecular mechanics (QM/MM) approaches. The redox potentials were evaluated using 10 quality metrics. The b
The development of sustainable photosensitiser complexes based on Earth-abundant metallic elements is important for sustainable solar energy conversion and green synthesis through photocatalysis. We report the synthesis and characterisation of a new bis(tripodal) iron(III) N-heterocyclic carbene complex [Fe(PhB{impy}3)2]+ (PhB{impy}3 = phenyltris(imidazo-[1,5-a]-pyridinylidene)borate) featuring -e
The standard of proof at the International Court of Justice (ICJ) is a central, yet underexplored, aspect of its judicial decision-making. Although central in shaping both fact-establishment and judicial outcomes, the articulation and application of the standard of proof by the Court are marked by inconsistency and a lack of transparent justification. This inconsistency is often linked to an assum
In mice, along with the assessment of eosinophils, lung function measurements, most commonly carried out by plethysmography, are essential to monitor the course of allergic airway inflammation, to examine therapy efficacy and to correlate animal with patient data. To date, plethysmography techniques either use intubation and/or restraining of the mice and are thus invasive, or are limited in their
Adsorption isotherms for a packed column consisting of fructose and silica gel in contact with a liquid phase consisting of oleic acid and fructose mono- and di-oleate at 65 °C were determined to assist the column’s utilization in a bioreactor system for the solvent-free lipase-catalyzed synthesis of saccharide ester biosurfactants. The liquid-phase fructose content was very low, ranging from 0.00
This paper examines the implications of platforms as a repertoire for knowing and relating the intensities of pandemic restrictions on teaching and schoolwork. Building on platformisation in education, what work platforms do in unpredictable everyday pedagogical encounters is investigated. Specifically, the paper explores a methodological potential with platforms’ capabilities to pull some things
I denna avhandling undersöktes exekutiva funktioner (EF) hos svenska barn och ungdomar. EF definierades som en uppsättning neurokognitiva processer som reglerar kognitiva, emotionella och beteendemässiga aktiviteter, viktiga för målinriktat handlande. EF bedömdes med hjälp av själv-, föräldra- och lärarskattningar av den första och andra upplagan av Behavior Rating Inventory of Executive Function This thesis examines executive functioning (EF) among Swedish youth. EF is defined as a set of neurocognitive processes regulating cognitive, emotional, and behavioral activities essential for goal-directed behavior. I assessed EF using the self-, parent-, and teacher-report forms from the original and second editions of the Behavior Rating Inventory of Executive Function (BRIEF and BRIEF2). A pri
Sepsis remains a major clinical challenge due to the limited efficacy of existing therapies in controlling excessive inflammation. The engineered stapled peptide sHVF18, derived from an evolutionarily conserved thrombin innate fold, binds both lipopolysaccharide (LPS) and the LPS-binding groove of CD14, enabling dual targeting of bacterial components and host immune signaling. To define structural
Film Installation at Group Exhibition: Museum Van Bommel Van DamThey are caught in a constant dilemma: should they join the game played by male world leaders, or distance themselves from it completely? As the film progresses, the situation becomes more threatening and the debate more complex. ⏳ The solution at the end proves to be as logical as it is difficult to carry out.Two Minutes to Midnight
The Middle Darriwilian Isotopic Carbon Excursion (MDICE) is one of the globally recognized positive excursions in carbon isotope chemostratigraphy, but mainly documented by δ13Ccarb data in previous research. In this paper, new stable organic carbon isotope data (δ13Corg) are presented from the Hule-1 core from the southern Anhui Province of southern China. The core constitutes an Ordovician silic
