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Primary hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder associated with autosomal recessive variants in genes required for perforin-mediated lymphocyte cytotoxicity. A rapid diagnosis is crucial for successful treatment. Although defective cytotoxic T lymphocyte (CTL) function causes pathogenesis, quantification of natural killer (NK)–cell exocytosis triggered by K562 targe
Background: Ocrelizumab is a humanized anti-CD20 antibody with increased antibody-dependent cellular cytotoxicity compared with rituximab. This phase I/II study evaluated its safety and efficacy in patients with relapsed/refractory follicular lymphoma (FL) after prior rituximab therapy. Design and methods: Forty-seven patients were treated in three dose cohorts and received eight infusions every 3
Streptococcus pyogenes (Group A streptococcus; GAS) is an important human pathogen responsible for mild to severe, life-threatening infections. GAS expresses a wide range of virulence factors, including the M family proteins. The M proteins allow the bacteria to evade parts of the human immune defenses by triggering the formation of a dense coat of plasma proteins surrounding the bacteria, includi
Recent epidemiological data on diseases caused by beta-hemolytic streptococci belonging to Lancefield group C and G ( GCS, GGS) underline that they are an emerging threat to human health. Among various virulence factors expressed by GCS and GGS isolates from human infections, M and M-like proteins are considered important because of their anti-phagocytic activity. In addition, protein G has been i
Streptococcus pyogenes is one of the most common bacteria infecting humans. One of the factors contributing to the disease-causing properties is the secreted streptococcal cysteine proteinase, SpeB, which degrades several host proteins in connective tissue and circulation. SpeB activity depends on the transformation from an inactive precursor, zymogen, into a mature proteinase. We show that
Human financial decisions are known to deviate from ‘rational’, particularly under uncertainty and if time delays are involved. In the Nobel-winning prospect theory, Tversky and Kahneman showed that deviations from rational behavior were not only robust but also quite predictable, if considering average behavior in a population. They found that people consider gains and losses not in absolute term
Denna uppsats behandlar uppsägningsgrunden arbetsbrist och begränsningar i arbetsgivarens arbetsledningsrätt vid uppsägning. Med arbetsbrist avses i lagens mening inte enbart brist på verkliga arbetsuppgifter för arbetstagarna utan även en mängd andra situationer där arbetstagare blir överflödiga. Lagen om anställningsskydd är, i situationer då arbetsbrist föreligger, inte tänkt att ge ett befattn
Fencing ‘Risky’ Mobilities in the Eastern German Borderlands with Poland Tisdag 9 maj kl. 14.30-15.30 Larissa Fleischmann från Martin Luther University Halle-Wittenberg höll en presentation, som följdes av diskussion med Tracie Wilson från Ludwig-Maximilians-Universität, och frågor från deltagare. Seminariet hölls på Zoom. Larissa Fleischmann is a researcher in human geography, whose work centers
https://www.cors.lu.se/formular/more-human-borderlands-disease - 2026-07-21
