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Hemoglobin (Hb) is well protected inside the red blood cells (RBCs). Upon hemolysis and when free in circulation, Hb can be involved in a range of radical generating reactions and may thereby attack several different biomolecules. In this study, we have examined the potential damaging effects of cell-free Hb on plasmid DNA (pDNA). Hb induced cleavage of supercoiled pDNA (sc pDNA) which was proport
Julian D. Mortenson has written an article for the most recent issue of the American Journal of International Law which he has furnished with the title "The Travaux of Travaux: Is the Vienna Convention Hostile to Drafting History?" The article suggests a reading of Articles 31 and 32 of the 1969 Vienna Convention on the Law of Treaties that is radically different from the one generally assumed. As
This article is the outcome of two research trips to the Jain caves at Ellora, the purpose of which was to photograph the best preserved murals found there, works of art that were largely undocumented in any available literature. The article documents and portrays the best preserved paintings in detail found on the walls and ceiling of one of the smaller caves belonging to the largest Jain cave co
AbstractBackground: Around one fourth of patients with colorectal cancer present themselves with distant metastases at the time of diagnosis, and one additional one fifth of the patients will develop distant metastases during the disease, most commonly in the liver. Surgical treatment such as liver resection or ablation, often combined with chemotherapy and targeted therapy, is the only treatment BackgroundAround one fourth of patients with colorectal cancer present themselves with distant metastases at the time of diagnosis, and one additional one fifth of the patients will develop distant metastases during the disease, most commonly in the liver.Surgical treatment such as liver resection or ablation, often combined with chemotherapy and targeted therapy, is the only treatment option with
We apply the GARCH-copula method to estimate Value at Risk (VaR) for European and Stockholm stock indices. First, marginal distributions are estimated by the ARMA-GARCH model with normal, Student-t, and skewed t distributions. Then we investigate the tails of innovations of ARMA-GARCH models using the Peaks over thresholds method and find that the distributions of stock returns are asymmetric
Fencing ‘Risky’ Mobilities in the Eastern German Borderlands with Poland Tisdag 9 maj kl. 14.30-15.30 Larissa Fleischmann från Martin Luther University Halle-Wittenberg höll en presentation, som följdes av diskussion med Tracie Wilson från Ludwig-Maximilians-Universität, och frågor från deltagare. Seminariet hölls på Zoom. Larissa Fleischmann is a researcher in human geography, whose work centers
https://www.cors.lu.se/formular/more-human-borderlands-disease - 2026-07-11
In this paper, the authors report the use of liquid-liquid partition chromatography (LLPC) in an aqueous polyethylene glycol (PEG)/dextran two-phase system to compare the surface properties (partition properties) of human antibodies and fragments thereof. The surface properties of all the monoclonal antibodies of different classes and subclasses investigated were within the same broad range as tha
A one-step HPLC method was developed for the purification of protein G, a cell wall molecule from group C and G streptococci with immunoglobulin G- and albumin-binding properties. Lysed Escherichia coli bacteria infected with lambda-phages containing the protein G gene from group G streptococci were used as a starting material for the preparations. The lysate was applied to a column with immobiliz
To investigate the effects of a vitamin D3 analogue (BXL628) in a model of chronic cystitis, as calcitriol analogues might be an interesting new therapeutic option for interstitial cystitis, for although the cause of the disease remains unclear, the increase in mast cells in the mucosa and detrusor muscle are significant. We devised a mouse model of allergen-induced allergic cystitis that is assoc
Glycoprotein B (gB, gpUL55) is a major antigen for the induction of neutralizing antibodies against human cytomegalovirus, making it an attractive antigen for active and passive immunoprophylaxis. The immunodominant region on gB is the antigenic domain 1 (AD-1), a complex structure which requires a minimal linear amino acid sequence of more than 75 amino acids (aa 552-635) for antibody binding. We
The Group A streptococcus (GAS) (Streptococcus pyogenes) is a significant human pathogen known for causing a diverse range of diseases, spanning from mild diseases such as pharyngitis to life-threatening diseases such as necrotizing fasciitis. Its virulence comes from a plethora of immune evasion mechanisms, but the M protein with its hypervariable region and ability to bind human proteins, stands
Viktig information (In English further down)Förmedling av kursresultatDet är av högsta vikt att vi ser över våra rutiner hur vi förmedlar kursresultat till studenterna. Det är varje kursansvarig lärares ansvar att riktlinjerna nedan följs. TLTH och studieråden har fått i uppgift att återrapportera till LGGU om vi gör regelbrott. Notera att inga resultatlistor i någon form (dugga, extra poäng etc)
https://www.intradesign.lth.se/forska-och-utbilda/grundutbildning/riktlinjer-kursresultat - 2026-07-11
Background: The accumulation of amyloid-β1−42 (Aβ1−42) peptides and phosphorylated-Tau181 (p-Tau181) tangles from the preclinical stages of Alzheimer’s disease (AD) has led to a biological definition of the disease. However, among Aβ1−42-positive individuals, cognitive decline onset varies, and some never develop symptoms. Genetic influences on molecular pathways and their interactions with protei
