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Background. Anti-glomerular basement membrane (anti-GBM) disease often results in end-stage renal failure despite therapy with plasma exchange and immunosuppressive drugs. The newly discovered streptococcal enzymes IgG-degrading enzyme of S.pyogenes (IdeS) and endoglycosidase S (EndoS) act with remarkable specificity on circulating IgG. In this study, we investigate their ability in vivo to preven
Pareto optimality is a concept that formalises the trade-off between a given set of mutually contradicting objectives. A solution is said to be Pareto optimal when it is not possible to improve one objective without deteriorating at least one of the other. A set of Pareto optimal solutions constitute the Pareto front. The Pareto concept applies well to the inverse planning process, which involves
In the current work, cationic polymers functionalized with N-alicyclic quaternary ammonium (QA) cations were synthesized and characterized as potential hydroxide exchange membranes (HEMs) for application in fuel cells. Three different polymers, namely poly(arylene ether sulfone), spiro-ionene and poly(arylene alkylene), were explored as polymer backbones for the HEMs. Various mono- and spirocyclic
In the study presented in this paper, the effect of different vehicle driving cycles on the pneumatic hybrid has been investigated. The pneumatic hybrid powertrain has been modeled in UT-Power and validated against experimental data. The GT-Power engine model has been linked with a MATLAB/simulink vehicle model. The engine in question is a single-cylinder Scania D12 diesel engine, which has been c
Abstract Through the use of chimeric CXCR4/CCR5 receptors we have previously shown that CCR5-tropic (R5) HIV-1 isolates acquire a more flexible receptor use over time, and that this links to a reduced viral susceptibility to inhibition by the CCR5 ligand RANTES. These findings may have relevance with regards to the efficacy of antiretroviral compounds that target CCR5/virus interactions. Compartme
Lärare Kontaktinformation E-post: ida [dot] knutsson [at] mhm [dot] lu [dot] seOrganisation Lärare (Musikhögskolan) WebbplatsIda Knutssons profil i Lunds universitets forskningsportal Publikationer Visar av publikationer. Sorterade efter år och sen titel. Filtrera efter typ AllaAnnanArtikel i vetenskaplig tidskriftDoktorsavhandling (sammanläggning)KonferensabstractKonferenspaper, ej i proceeding/e
https://www.mhm.lu.se/ida-knutsson - 2026-07-04
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease driven by persistent fibroblast activation, abnormal epithelial to mesenchymal signaling and excessive extracellular matrix (ECM) remodeling. Better pre-clinical models are needed to reproduce these processes and to support antifibrotic drug development. This thesis tested whether an in vitro co-culture model
This thesis is an extension to the previous work done at Department of EIT in investigating the complexity reduction of LDPC decoding using the stochastic approximation method to improve the energy efficiency of energy-limited applica- tions, such as in mobile phones. The research carried out in this thesis investigates the complexity and conver- gence results of adaptive performance control algorit
The function of cultured mast cells may depend on genetic or environmental influence on the stem cell donor. This study investigates whether asthma or atopy in the donor influenced the growth and sensitivity of mast cells cultured from patients with asthma and healthy controls under identical conditions. Mast cells were cultured from peripheral blood from twelve patients with an objectively confir
Shiga toxin-producing Escherichia coli O157:H7 is a virulent strain causing severe gastrointestinal infection, hemolytic uremic syndrome and death. To date there are no specific therapies to reduce progression of disease. Here we investigated the effect of pooled immunoglobulins (IgG) on the course of disease in a mouse model of intragastric E. coli O157:H7 inoculation. Intraperitoneal administrat
Introduction: Subanesthetic doses of ketamine are a promising novel treatment for suicidality; however, the evidence for predictive biomarkers is sparse. Recently, measures of complexity, including Lempel–Ziv complexity (LZC) and multiscale entropy (MSE), have been implicated in ketamine's therapeutic action. We evaluated electroencephalogram (EEG)-derived LZC and MSE differences between responder
Group A streptococcus (GAS) is a highly adapted, human-specific pathogen that is known to manipulate the immune system through various mechanisms. GAS’ M protein constitutes a primary target of the immune system due to its spatial configuration and dominance on the bacterial surface. Antibody responses targeting the M protein have been shown to favor the conserved C region. Such antibodies (Abs) c
Delivery of antigenic peptides to antigen presenting cells (APCs) such as dendritic cells (DCs) using monoclonal antibodies (mAbs) is an attractive approach to evoke antigen-specific T cell activation and improve drug efficacy. Peptide linkage to mAbs has previously been achieved through genetic fusion, chemical conjugation, nano-engineered platforms and high affinity peptides. In this study, we h
Insikt och Handling 16 INSIKT OCH HANDLING Utgiven av Hans Larsson Samfundet Volym 16 DOXA REDAKTÖR: BO HANSON SANDGATAN 8, 22350 LUND TRYCKNING: WALLIN & DALHOLM AB, LUND 1988 ISSN: 0436-8096 ISBN: 91-578-0249-1 TRYCKT MED BIDRAG FRÅN ANDERS KARITZ’ STIFTELSE PDF: TABULA, MÄRSTA 2020 ISBN: 978-91-88702-26-5 VERSION 1.0 — 2020-05-15 – 2 – Innehåll 4 Musikens mening En problem- och diskussionsövers
https://www.fil.lu.se/fileadmin/user_upload/fil/dokument/hanslarsson/Insikt_och_handling_vol_16.pdf - 2026-07-04
Popular Abstract in Swedish Under de senaste par decennierna har en specifik tolkning av döva och dövhet blivit alltmer etablerad på det ”officiella” dövområdet i Sverige, tillika anammat av såväl professionella som föräldrar till döva barn. Döva ska enligt detta synsätt hellre betraktas som tillhörande en kulturell och språklig minoritet än som handikappade. Medicinska strävanden att “laga defektIn the last couple of decades a particular interpretation of deaf and deafness has been established in ‘official’ arenas in Sweden. Deaf individuals, according to this view, should not be seen as disabled, but rather as belonging to a cultural and linguistic minority. Such views find expression in a locally established usage that may be termed a deaf culture discourse. Discourse can be seen as a
Demenssjukdomar är svåra att diagnostisera – Vetenskap och Hälsa Hoppa till innehåll Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Demenssjukdomar är svåra att diagnostisera 2011-05-26 ⚠️ Den här artikeln är mer än 5 år gammal. Nya forskningsrön kan ha tillkommit. Foto: Dreamstime Många patienter får fel deme
https://www.vetenskaphalsa.se/demenssjukdomar-ar-svara-att-diagnostisera/ - 2026-07-05
Demenssjukdomar är svåra att diagnostisera – Vetenskap och Hälsa Hoppa till innehåll Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Demenssjukdomar är svåra att diagnostisera 2011-05-26 ⚠️ Den här artikeln är mer än 5 år gammal. Nya forskningsrön kan ha tillkommit. Foto: Dreamstime Många patienter får fel deme
https://www.vetenskaphalsa.se/demenssjukdomar-ar-svara-att-diagnostisera/comment-page-1/ - 2026-07-05
Gender equality has become a top priority worldwide. However, gender tends to be synonymous with women and the agency of men is too often marginalised in both development interventions and research. Previous studies have found that as men are not included in the Gender and Development paradigm a “crisis of masculinity” is occurring which implies that sustainable gender equality will be more diffic
