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Checkpoint blockade therapies that reactivate tumour-associated T cells can induce durable tumour control and result in the long-term survival of patients with advanced cancers1. Current predictive biomarkers for therapy response include high levels of intratumour immunological activity, a high tumour mutational burden and specific characteristics of the gut microbiota2,3. Although the role of T c
Wetland area in agricultural landscapes has been heavily reduced to gain land for crop production, but in recent years there is increased societal recognition of the negative consequences from wetland loss on nutrient retention, biodiversity and a range of other benefits to humans. The current trend is therefore to re-establish wetlands, often with an aim to achieve the simultaneous delivery of mu
The primary objective of this multicenter, multinational, epidemiological study is the identification of infectious agents, dietary factors, or other environmental exposures that are associated with increased risk of autoimmunity and type 1 diabetes mellitus (T1DM). Factors affecting specific phenotypic manifestations such as early age of onset or rate of progression or with protection from the de
BACKGROUND: Urothelial carcinoma is the predominant (95%) bladder cancer subtype in industrialized nations. Animal and epidemiologic human studies suggest that hormonal factors may influence urothelial carcinoma risk. METHODS: We used an analytic cohort of 333,919 women from the European Prospective Investigation into Cancer and Nutrition Cohort. Associations between hormonal factors and incident
Acute myeloid leukemia (AML) is defined by an accumulation of immature myeloid blasts in the bone marrow. To identify key dependencies of AML stem cells in vivo, here we use a CRISPR-Cas9 screen targeting cell surface genes in a syngeneic MLL-AF9 AML mouse model and show that CXCR4 is a top cell surface regulator of AML cell growth and survival. Deletion of Cxcr4 in AML cells eradicates leukemia c
Background: The term prurigo has been used for many decades in dermatology without clear definition, and currently used terminology of prurigo is inconsistent and confusing. Especially, itch-related prurigo remains unexplored regarding the epidemiology, clinical profile, natural course, underlying causes, available treatments and economic burden, although burdensome and difficult to treat. Objecti
BACKGROUND: Human B lymphocytes can produce leukotriene B4 but the biological function of the 5-lipoxygenase (5-LO) pathway in B cells is unclear. In order to better understand and define the role of 5-LO in B cells, we investigated the expression of 5-LO mRNA and protein in subsets of B cells from human tonsils and different types of B cell lymphoma.RESULTS: Based on RT-PCR and western blot/immun
Background: In patients undergoing resection for pancreatic cancer, adjuvant modified fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) improves overall survival compared with alternative chemotherapy regimens. We aimed to compare the efficacy and safety of neoadjuvant FOLFIRINOX with the standard strategy of upfront surgery in patients with resectable pancreatic ductal adenocarci
Background: Breathlessness is common in the population and can be related to a range of medical conditions. We aimed to evaluate the burden of breathlessness related to different medical conditions in a middle-aged population. Methods: Cross-sectional analysis of the population-based Swedish CArdioPulmonary bioImage Study of adults aged 50–64 years. Breathlessness (modified Medical Research Counci
Masterutbildning i logistik och styrning av försörjningskedjor utbildningsplan Sida 1 av 7 UTBILDNINGSPLAN Masterutbildning i logistik och styrning av försörjningskedjor - Programkod: TALSF - Omfattning: 120 högskolepoäng - Tillträdesnivå: Avancerad nivå - Beslutsfattare: Programledning I - Utbildningsplanens giltighet: 2022/2023 - Utbildningsplanen fastställd: 2022-02-17 Förutom utbildningsplanen
Kurskommentar Matematik för naturvetare vt 2020 Anders Olofsson Resultatet p̊a kursen är 5 stycken G och 35 stycken VG p̊a tentamenstillfället den 19 mars, 2020. De inkomna kursvärderingarna var genomg̊aende positiva, se r̊adata för detaljer. Tentamen och repetition inför tentamen stördes av korona-utbrottet v̊aren 2020. Den planerade salstentamen med skrivningsvakter etc. blev med kort var
https://www.maths.lu.se/fileadmin/maths/Matematik_NF/Kursutvaerderingar/VT2020/MATA02VT2020KA.pdf - 2025-11-03
Rättighetslistan för Lunds universitets studenter 2 3 Rättighetslistan för Lunds universitets studenter innehåller rättig- heter och skyldigheter som har att göra med behörighet och urval, studiemiljö, kursplaner och schema, prov och examination, examens- arbeten och kursvärdering. Syftet med listan är att underlätta för studenterna att genomföra sina studier, att tillgodose att de ska kunna få ut
https://www.kom.lu.se/fileadmin/user_upload/kom/Filer/PDF/Diverse/handbok-rattighetslistan-webb.pdf - 2025-11-03
1 Filologkongressen IX, Lund Tisdag 12 maj 11.30–12.30 Session 4: Textutgivningsworkshop med Stephan Borgehammar ”Early Thirteenth-Century Sermons from Alvastra Abbey – Editorial Problems” If it originated in Sweden, the collection of sermons found in Uppsala University Library ms. C 37 is the earliest Swedish example of sermon writing to have survived. It is also the only example of sermons from
https://konferens.ht.lu.se/fileadmin/_migrated/content_uploads/Filologkongressen_intro.pdf - 2025-11-03
DESIGN OF A GLASS FLOOR STRUCTURE Master’s Dissertation Structural Mechanics PONTUS DUFVENBERG and FREDRIK JÖNSSON DESIGN OF A GLASS FLOOR STRUCTURE DEPARTMENT OF CONSTRUCTION SCIENCES DIVISION OF STRUCTURAL MECHANICS ISRN LUTVDG/TVSM--14/5192--SE (1-65) | ISSN 0281-6679 MASTER’S DISSERTATION Supervisor: PER-ERIK AUSTRELL, Assoc. Professor; Div. of Structural Mechanics, LTH, Lund. Examiner: KENT P
https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5192.pdf - 2025-11-03
Anemia because of insufficient production of and/or response to erythropoietin (Epo) is a major complication of chronic kidney disease and cancer. The mechanisms modulating the sensitivity of erythroblasts to Epo remain poorly understood. We show that, when cultured with Epo at suboptimal concentrations, the growth and clonogenic potential of erythroblasts was rescued by transferrin receptor 1 (Tf
The need for non-animal data to assess skin sensitisation properties of substances, especially cosmetics ingredients, has spawned the development of many in vitro methods. As it is widely believed that no single method can provide a solution, the Cosmetics Europe Skin Tolerance Task Force has defined a three-phase framework for the development of a non-animal testing strategy for skin sensitisatio
BACKGROUND The association between aging-related testosterone deficiency and late-onset hypogonadism in men remains a controversial concept. We sought evidence-based criteria for identifying late-onset hypogonadism in the general population on the basis of an association between symptoms and a low testosterone level. METHODS We surveyed a random population sample of 3369 men between the ages of 40
We determine the properties of the binary star V106 in the old open cluster NGC6791. We identify the system to be a blue straggler cluster member by using a combination of groundbased and Kepler photometry and multi-epoch spectroscopy. The properties of the primary component are found to be Mp ~ 1.67M⊙, more massive than the cluster turn-off, with Rp ~ 1.91R⊙ and Teff = 7110 ± 100 K. The secondary
