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Traumatic brain injury causes long-term neurological motor and cognitive deficits, often with limited recovery. The inability of CNS axons to regenerate following traumatic brain injury may be due, in part, to inhibitory molecules associated with myelin. One of these myelin-associated proteins, Nogo-A, inhibits neurite outgrowth in vitro, and inhibition of Nogo-A in vivo enhances axonal outgrowth

The Environmental Determinants of Diabetes in the Young (TEDDY) study enrolled 8676 children, 3-4 months of age, born with HLA-susceptibility genotypes for islet autoimmunity (IA) and type 1 diabetes (T1D). Whole-genome sequencing (WGS) was performed in 1119 children in a nested case-control study design. Telomere length was estimated from WGS data using five tools: Computel, Telseq, Telomerecat,

Medial temporal lobe (MTL) subregions play integral roles in memory function and are differentially affected in various neurological and psychiatric disorders. The ability to structurally and functionally characterize these subregions may be important to understanding MTL physiology and diagnosing diseases involving the MTL. In this study, we characterized network architecture of the MTL in health

Induced pluripotent stem cells (iPSCs) can in principle differentiate into any cell of the body, and have revolutionized biomedical research and regenerative medicine. Unlike their human counterparts, mouse iPSCs (miPSCs) are reported to silence transposable elements and prevent transposable element-mediated mutagenesis. Here we apply short-read or Oxford Nanopore Technologies long-read genome seq

BACKGROUND: After breast-conserving surgery, radiotherapy reduces recurrence and breast cancer death, but it may do so more for some groups of women than for others. We describe the absolute magnitude of these reductions according to various prognostic and other patient characteristics, and relate the absolute reduction in 15-year risk of breast cancer death to the absolute reduction in 10-year re

1. The impacts of nutrients (phosphorus and nitrogen) and planktivorous fish on phytoplankton composition and biomass were studied in six shallow, macrophyte-dominated lakes across Europe using mesocosm experiments. 2. Phytoplankton biomass was more influenced by nutrients than by densities of planktivorous fish. Nutrient addition resulted in increased algal biomass at all locations. In some exper

Popular Abstract in Swedish Reumatoid artrit/ledgångsreumatism (RA) är en kronisk inflammatorisk sjukdom som i första hand drabbar lederna. Man uppskattar sjukdomens förekomst i den vuxna befolkningen till cirka en halv procent och den är 2-4 gånger vanligare hos kvinnor. Vi vet inte vad som orsakar RA, men såväl ärftliga som omgivningsfaktorer har betydelse. RA har ett varierande förlopp. Dels kaRheumatoid arthritis (RA) is characterized by persistent inflammation, progressive joint damage and disability. This thesis describes the outcome after 10 years in a cohort of 183 RA patients (116 women, 67 men) recruited 1985-89. The mean age was 51 years and symptom duration 11 months at inclusion. Standardized clinical, biochemical and radiographic assessments were performed annually. Health st

Popular Abstract in Swedish En deletion innebär att det fattas en bit DNA i en kromosom. Deletioner kan variera i storlek från enstaka baspar till en stor del av en kromosom. Deletioner kan orsaka sjukdomar, men det finns också exempel på deletioner som inte ger någon påvisbar effekt på individen. Genom att analysera genetiska markörer i familjer kan man hitta mönster som kan förklaras av deletionA deletion is defined as a missing piece of a chromosome, ranging in size from as small as a single base pair to as much as an entire arm of a chromosome. Deletions can cause diseases, but may also have a neutral effect in the genome. In this thesis, I describe how inherited deletions can be detected by analysis of the segregation pattern of genetic markers in pedigrees. These methods are based on

Title: Motherhood Means Business: a motivational factor in entrepreneurship Seminar date: 1 June 2023 Course: FEKH99, Bachelor Degree Project in Entrepreneurship and Innovation Management, Business administration, 15 University Credit Points Authors: Molly Eklund, Isa Stinger & Stina Svensson Advisor: Ziad El-Awad Keywords: Mother entrepreneurship; motivational factors; Push and Pull theory; O

Cementstabiliserad asfalt (CSA) är ett kompositslitlager bestående av en asfaltbeläggning med högt hålrum som är fyllt med en cementbaserad slamma. Produkten kan därför kallas för ett semiflexibelt slitlager på grund av att egenskaper från både asfalt och betong kombineras. Egenskaperna som kännetecknar CSA är asfaltens elasticitet samt cementens bärighet och beständighet, hög motståndskraft mot kCement stabilized asphalt (CSA) is a composite layer consisting of an asphalt with high cavity which is filled with a cement-based slurry. The product can therefore be called a semiflexible wearing course because of its combined characteristics from both asphalt and concrete. The characteristic features of CSA are the asphalts elasticity and the cements buoyancy and resistance, high resistance aga

En av de mest grundläggande principerna inom aktiebolagsrätten och en stark bidragande faktor till dess popularitet återfinns i 1 kap. 3 § ABL, dvs. aktieägare är som huvudregel inte personligt ansvariga för bolagets förpliktelser. Till varje huvudregel finns undantag och så även här. I Sverige har det diskuterats om aktieägare trotsallt ska kunna hållas ansvariga för bolagets förpliktelser genom One of the most fundamental principles of company law and a strong contributing factor to its popularity can be found in chapter 1. article 3 in the Swedish Companies Act, i.e. shareholders, as a general principle, are not personally responsibility for the debts or actions of a corporation. To every general principle exists exceptions, which applies here as well. In Sweden, the question has been r

Syftet med denna rapport var att problemen med underhållsprogram skulle undersökas och sedan till en viss mån lösas. Det fanns 3 frågeställningar i denna rapport och dessa var vilka problem som användarna upplever med underhållsprogram, hur problemen kan lösas och vad underhållsprogram används till idag och vad dessa kommer användas till i framtiden. Undersökningen genomfördes genom intervjuer medThe purpose of this report was to investigate and to some extent resolve the problems with maintenance programs. There were 3 aims in this report and these were what problems the users experience with maintenance programs were going to be enlightened, that the problems were going to be solved and what maintenance programs are used for today and what they will be used for in the future were to be i

För att öka användningen av digitala betaltjänster, såsom BankID, inom Europeiska unionen (EU) tillkom andra betaltjänstdirektivet (PSD2) år 2015. I Sverige implementerades PSD2 genom tillskottet av kapitel 5a i Lag (2010:751) om betaltjänster. En grundregel är att en betaltjänstgivare är skyldig att återställa användarens konto vid obehöriga transaktioner, med vissa undantag. Enligt 5a kap 3§ kanTo enhance the utilization of digital payment services, such as BankID, within the European Union (EU), the second Payment Services Directive (PSD2) was introduced in 2015. In Sweden, PSD2 was implemented through the addition of Chapter 5a in the Act (2010:751) on Payment Services. A fundamental rule is that a payment service provider is obligated to restore the user's account in the case of u

Den 25 maj 2018 antogs direktiv (EU) 2018/822 om ändring av direktiv 2011/16/EU vad gäller obligatoriskt utbyte av upplysningar i fråga om beskattning som rör rapporteringspliktiga arrangemang (DAC 6). Direktivet är ett led i EU:s samarbete på skatteområdet och är till stor del inspirerat av OECD:s arbete mot aggressiv skatteplanering. Direktivet syftar till att stävja aggressiv skatteplanering i On May 25, 2018, Council Directive (EU) 2018/882 amending Directive 2011/16/EU as regards mandatory automatic exchange of information in the field of taxation in relation till reportable cross-border arrangements (DAC 6) was adopted. The directive is part of the EU’s administrative cooperation in the field of taxation and is largely inspired by the OECD’s work against aggressive tax planning. The

Tre borrkärnor bestående av sjösediment, vardera 1.5 meter långa, från Byestadsjön i Småland, Sverige studerades med hjälp av mineralmagnetiska- kol- pollen- och röntgenflourosens (XRF)- analyser. Målet med studien var att rekonstruera tidig Holocen miljö, med fokus på tiden mellan 9000-7000 år sedan och därmed avgöra om det kalla klimatåterslaget cirka 8200 före nutid påverkade regionen eller ej.Three sediment cores, each 1.5 meters in length, obtained from Lake Byestadsjön in the province of Småland, southern Sweden were studied with high resolution mineral magnetic measurements, carbon content, pollen analysis and XRF analysis. The aim was to reconstruct the early Holocene environment, with focus on the period between 9000-7000 cal yr BP, and thereby conclude if the 8200 cal yr BP cooli

Genetic factors are important in the pathogenesis of osteoporosis and the estrogen receptor has been suggested as a possible candidate gene for regulation of bone mineral density (BMD). We investigated the relationship between PvuII, XbaI, and dinucleotide (TA)n repeat polymorphisms of the estrogen receptor alpha (ER-alpha) gene and BMD in a study of women from northeast Scotland in the United Kin

Most of the care in nursing homes is palliative in nature, as it is the oldest and the frailest people who live in nursing homes. The aim of this study was to explore next of kin’s experiences of participating in the care of older persons at nursing homes. A qualitative design was used, based on semi-structured interviews with 40 next of kin, and analyzed using qualitative content analysis. An oveMost of the care in nursing homes is palliative in nature, as it is the oldest and the frailest people who live in nursing homes. The aim of this study was to explore next of kin's experiences of participating in the care of older persons at nursing homes. A qualitative design was used, based on semi-structured interviews with 40 next of kin, and analyzed using qualitative content analysis. An ove

A series of experiments was made at the Virology Department of the "Pedro Kourí" Institute of Tropical Medicine aimed at obtaining new evidences on the possible antigenic relations existing between the viruses isolated from patients with epidemic neuropathy and the structures of the human nervous system. According to the results it may be finally inferred that the persistence and/or autoimmunity m