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This study employs computational algorithms to automatically identify and classify features in X-Ray fluorescence (XRF) microscopy images. Principal component analysis (PCA) and unsupervised machine learning algorithms, such as Gaussian mixture (GM) clustering, are implemented to label features on a collection of XRF maps of human atherosclerotic plaque samples. The investigation involves the hard
The interaction between a low angle grain boundary in front of a crack tip and the emerging plasticity from the tip of a microstructurally short edge crack subjected to fatigue loading has been studied. The modeling rests solely on discrete dislocations, were the geometry is described by dislocation dipole elements in a boundary element approach and the plasticity, restricted to one slip plane, to
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the benefits and harms of methylxanthines in preventing or treating intermittent hypoxemia or respiratory insufficiency in late preterm infants.
Recent technologies of district heating and cooling (DHC) systems integrate renewable energy sources and connect multiple heat producers and consumers to the same network. The resulting interactions may therefore cause the fluid in the pipe, or the energy carried by the system, to flow in both directions. This article presents a newly developed analytical method for evaluating the hydraulic states
Parkinson's disease is a neurodegenerative condition characterized by motor impairments caused by the selective loss of dopaminergic neurons in the substantia nigra. Levodopa is an effective and well-Tolerated dopamine replacement agent. However, levodopa provides only symptomatic improvements, without affecting the underlying pathology, and is associated with side effects after long-Term use. Cel
We present the design of the vacuum chamber for the LNLS 2T Hybrid Wiggler. The chamber is a 3m long, 1.2mm thick 316L SS tube, which was mechanically pressed into an elliptical shape from an originally round tube. In order to provide the necessary mechanical tolerances, the rather flexible tube is welded to lateral supports that run the complete length of the chamber. Special care has been given
Introduction: The 2024 ISTH clinical practice guideline (CPG) for treatment of congenital haemophilia, the NBDF-McMaster Guideline on Care Models for Haemophilia Management, and ASH ISTH NBDF WFH guidelines on the diagnosis and management of VWD all utilised GRADE methodology. Aim: Discuss missed opportunities and the methodological approach of the ISTH Guideline in contrast to how GRADE was previ
BACKGROUND AND AIM: Warming temperature promotes bacterial growth while extreme precipitation enhances fecal-oral route of exposures to these pathogens, particularly in resource limited settings, increasing burden of diarrheal diseases. Given climate change related increases in frequency of extreme events, there is a pressing need to develop meaningful early warning system with adequate lead time
This presentation presents a method for using Large Language Models (LLMs) to structure historical data about Swedish musical history. The research builds on the existing, human-created Stockholm Concert Database of concerts occurring in Stockholm between 1848-1908. Using this as a starting point, it details an experiment in automated extraction of information about concerts from historical Swedis
PURPOSE OF REVIEW: Small cell lung cancer (SCLC) is an aggressive disease with a poor prognosis, whereas its metastatic capacity carries a predilection for the brain. Although prophylactic cranial irradiation (PCI) has been used to address this problem, upcoming alternatives might necessitate reflection of its application in SCLC treatment. RECENT FINDINGS: The addition of immunotherapy to treatme
Purpose: To remedy the lack of a measure that jointly assesses the psychological status and impact of migration stressors among forced migrants, we developed and tested the Screening of Refugees Self-Report (ScoRE-SR) Questionnaire.Method: Four institutions with expertise on posttraumatic symptomatology and/or migration stressors developed the ScoRE-SR through an iterative process also involving c
This paper explores how pro-active government policies could promote artificial intelligence (AI) in healthcare for the public good. Building on insights from the literature on industrial policy, we argue that without clear conditions and guardrails to ensure future public benefit, state assistance and subsidies will be nothing more than corporate welfare with unpredictable, if any, societal benef
In pursuit of advancing the capabilities of ground testing facilities, a complete road map for broadening operational range of the H3 hypersonic blowdown wind tunnel, operated at the von Karman Institute for Fluid Dynamics (VKI), with the addition of a new Mach 5 contoured nozzle is constructed. The main characteristics of the facility are presented. The supersonic ejector is identified as a criti
This CMES Regional Outlook by Pinar Dinc focuses on the recent political developments in Turkey.
Due to the large amount of accidents negatively affecting the wellbeing of the survivors and their families, a substantial amount of research is conducted to determine the causes of road accidents. This type of data come in the form of non-negative integers and may be modelled using the Poisson regression model. Unfortunately, the commonly used maximum likelihood estimator is unstable when the exp
In recent years, a growing interest in sustainable tourism and outdoor recreation has emerged in Sweden and globally. While a positive development for many reasons, it coincides with other shifting patterns in recreational nature use, influenced by climate change, social media, and experimental interventions in natural areas. These developments bring opportunities to broaden participation, but als
Atrial fibrillation and heart failure have both been suggested to increase stroke and dementia risk. However, in observational studies, reversed causation and unmeasured confounding may occur. To mitigate these issues, this study aims to investigate if higher genetic risk for atrial fibrillation and heart failure increases dementia and stroke risk. Data were obtained from the population-based Goth
Debate over the future of international science takes place in light of two trends that are frequently interpreted as standing in tension with each other. The longer-term pattern shows that science is increasingly an international endeavour, as collaboration across borders has grown. A more recent apparent re-nationalisation of science, however, raises questions over the march of international sci
