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Purpose: The purpose of this paper is to elaborate on how perspectives and assumptions embedded in the complexity paradigm contribute to make logistics management research better aligned with real-life logistics. This is necessary, due to increasing supply chain complexity caused by an increasing request for sustainable development (SD). Design/methodology/approach: The research is exploratory and
The minimum weighted edge dominating set problem (MWEDS) generalizes both the weighted vertex cover problem and the problem of covering the edges of graph by a minimum cost set of both vertices and edges. In this paper, we propose a meta heuristic approach based on genetic algorithm and local search to solve the MWEDS problem. Therefore, the proposed method is considered as a memetic search algori
Lawrence Summers produced a big upset within the economics profession when he revived Alvin Hansen’s theory of secular stagnation, which had been thought of as an old-Keynesian fallacy. While some economists like Brad DeLong and Paul Krugman instantly recognized Summers’s contribution, a large share of the economics profession remained skeptical at first. Whereas most New Keynesian models allow fo
A large Time Projection Chamber is the main device for tracking and charged-particle identification in the ALICE experiment at the CERN LHC. After the second long shutdown in 2019/20, the LHC will deliver Pb beams colliding at an interaction rate of about 50 kHz, which is about a factor of 50 above the present readout rate of the TPC. This will result in a significant improvement on the sensitivit
The European Spallation Source is being constructed in Lund, Sweden and is planned to be the world's brightest pulsed spallation neutron source for cold and thermal neutron beams (≤ 1 eV). The facility uses a 2 GeV proton beam to produce neutrons from a tungsten target. The neutrons are then moderated in a moderator assembly consisting of both liquid hydrogen and water compartments. Surrounding th
In this discussion paper, we outline and reflect on some of the key challenges that influence the development and uptake of more inclusive and responsible forms of research and innovation. Taking these challenges together, we invoke Collingridge’s famous dilemma of social control of technology to introduce a complementary dilemma that of ‘societal alignment’ in the governance of science, technolog
Imaging through turbid environments is experimentally challenging due to multiple light scattering. Structured laser illumination has proven to be effective to minimize errors arising from this phenomenon, allowing the interior of optically dense media to be observed. However, in order to preserve the image spatial resolution while suppressing the intensity contribution from multiple light scatter
Background: Effective digestive enzymes are crucial for successful islet isolation. Supplemental proteases are essential because they synergize with collagenase for effective pancreatic digestion. The activity of these enzymes is critically dependent on the presence of Ca2+ ions at a concentration of 5–10 mM. The present study aimed to determine the Ca2+ concentration during human islet isolation
BACKGROUND: The Self-Reported Foot and Ankle Score (SEFAS) is a foot- and ankle-specific patient-reported outcome measurement (PROM) score that has been validated with good results for a variety of foot and ankle disorders. SEFAS is sensitive detecting improvement or deterioration after surgery. However, normative values, required to put a specific patient's summary score into perspective, are lac
We developed a novel analytical method for concentration determination of tandem single-chain antibody diphtheria toxin (immunotoxin). The method is based on polymethacrylate monoliths with Protein L ligands as the binding moiety. Different buffers were tested for elution of the Protein L-bound immunotoxin and 4.5 M guanidinium hydrochloride performed best. We optimized the elution conditions and
The objective was to provide a clinical setup for photoacoustic imaging (PAI) of the temporal artery in humans and to describe the challenges encountered and methods of overcoming them. The temporal artery was examined in 7 patients with suspect giant cell arteritis (GCA), both in vivo and ex vivo, and the results were compared to that of histology. To adapt PAI to human studies, the transducer wa
The demand for water recovery in the industry is increasingly important partly due to water shortage and partly due to tightening of regulatory requirements. In this paper water recovery solutions for two challenging types of wastewater - oily and polyvinylchloride (PVC) wastewater - are presented. The first part of the presentation analyses the operation and performance of a membrane unit operate
The use of cross-flow ultrafiltration for the recovery of coating ma-terial from aqueous streams started about 30 years with electro deposition paint in the automotive industry. This early success can be related to both environmental and economical advantages of using ultrafiltration. Ultrafiltration recovers and concentrate electro deposition paint on the retentate side and produces purified wa
A set of key performance indicators (KPIs) for manufacturing operation management is introduced in the ISO 22400 standard. However, KPIs are only defined at a high abstraction level and this hampers the standard's practical adoption. In this paper, a framework is introduced in order to solve this weakness. Starting from the analysis of the relevant measurements used in the KPIs’ formulas, a classi
Wildfires are increasingly affecting forest landscapes around the world. In the Bolivian Chiquitania, southern Amazonia, large wildfires during recent droughts have intensified public debate around more systemic solutions to address the possible root causes. While the integration of different forms of fire knowledge is gaining acceptance as an approach to dealing with increasing wildfire risk, lit
Strongly selected characters can be transferred from one lineage to another with limited genetic exchange, resulting in asymmetric introgression and a mosaic genome in the receiving population. However, systems are rarely sufficiently well studied to link the pattern of introgression to its underlying process. Male common wall lizards in western Italy exhibit exaggeration of a suite of sexually se
Green packaging development (GPD) involves the process of developing packaging with minimized environmental impact. Over the last decade, the GPD perspective has evolved from a traditionally packaging material-focused one to a holistic one. A holistic perspective on GPD means that the different environmental requirements on packaging have to be combined so that the overall environmental impact of
Bacteria utilize complement regulators as a means of evading the host immune response. Here, we describe protocols for evaluating the role vitronectin acquisition at the bacterial cell surface plays in resistance to the host immune system. Flow cytometry experiments identified human plasma vitronectin as a ligand for the bacterial receptor outer membrane protein H of Haemophilus influenzae type f.
The parabolic equation is approximated by a set of ordinary differential equations and by finite difference equations. special attention is given to the approximation of the boundary condition. Some identities suitable to check numerical calculations are also derived.
