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As treatment evolves and the population who survive childhood cancer ages and increases in number, researchers must use novel approaches to prevent, identify and mitigate adverse effects of treatment. Future priorities include collaborative efforts to pool large cohort data to improve detection of late effects, identify late effects of novel therapies, and determine the contribution of genetic fac
The stacked multilevel (SML) klystron modulator topology has been suggested as an alternative to conventional pulse transformer-based topologies in an attempt to improve output pulse performance and reduce system size for long-pulse applications. In this topology, a power converter chain including a high-frequency transformer generates the output pulse in a pulse modulation/demodulation scheme, el
Collimated sprays of paticle, known as jets,are abundantly produced in high-energy proton-proton (pp) collisions, and are predicted by many theories of physics beyond the Standard Model. This thesis reports first on the calibration of jets with focus on the data-driven in situ calibration. Two searches for new physics phenomena in events with jets in the final state are then presented. The analyse
Prior to the COVID-19 crisis, global air transport demand was expected to triple between 2020 and 2050. The pandemic, which reduced global air travel significantly, provides an opportunity to discuss the scale, distribution and growth of aviation until 2018, also with a view to consider the climate change implications of a return to volume growth. Industry statistics, data provided by supranationa
INTRODUCTION: Infant iron status assessments may be difficult to interpret due to infections. The soluble transferrin receptor (sTfR) has been suggested as a biomarker mainly unaffected by the acute phase response. Reference intervals reflecting dynamics of infant growth first year in life are not well established.METHODS: The sTfR and CRP concentrations were measured in samples from 451 term infa
As a result of the energy performance of the buildings directive (EPBD 2010), the requirements have been gradually tightened in the Swedish building regulations. For the purpose of the directive to be realized, it is becoming increasingly important to ensure that buildings actually live up to the minimum rules laid down in the Swedish Building Regulations (BBR) or more ambitious requirements impos
This study focuses on the boundary-spanning nature of sustainable business model innovation, studying multi-stakeholder engagement and alignment. Drawing on the concept of boundary work, we explore the different types of organizational boundary changes between focal companies and their external stakeholders, investigating specifically the process of exploring, negotiating, disrupting and realignin
BACKGROUND: F8 int1h inversions (Inv1) are detected in 1-2% of severe hemophilia A (HA) patients. Long-range polymerase chain reaction (PCR) and inverse-shifting PCR have been used to diagnose these inversions.OBJECTIVES: To design and validate a sensitive and robust assay for detection of F8 Inv1 inversions.METHODS: Archival DNA samples were investigated using mile-post assays and droplet digital
Background: Global transcriptional profiling of individual cells represents a powerful approach to systematically survey contributions from cell-specific molecular phenotypes to human disease states but requires tissue-specific protocols. Here we sought to comprehensively evaluate protocols for single cell isolation and transcriptional profiling from heart tissue, focusing particularly on frozen t
The RNA integrity number (RIN) is a frequently used quality metric to assess the completeness of rRNA, as a proxy for the corresponding mRNA in a tissue. Current methods operate at bulk resolution and provide a single average estimate for the whole sample. Spatial transcriptomics technologies have emerged and shown their value by placing gene expression into a tissue context, resulting in transcri
As for the automotive industry, industry and academia are making extensive efforts to create autonomous ships. The solutions for this are very technology-intense. Many building blocks, often relying on AI technology, need to work together to create a complete system that is safe and reliable to use. Even when the ships are fully unmanned, humans are still foreseen to guide the ships when unknown s
BACKGROUND: Preterm infants are susceptible to hyperglycemia and hypoglycemia, conditions which may lead to adverse neurodevelopment. The use of continuous glucose monitoring devices (CGM) might help keeping glucose levels in the normal range, and reduce the need for blood sampling. However, the use of CGM might be associated with harms in the preterm infant. OBJECTIVES: Objective one: to assess t
From the catalytic, semiconducting, and optical properties of zinc oxide (ZnO) numerous potential applications emerge. For the physical and chemical properties of the surface, under-coordinated atoms often play an important role, necessitating systematic studies of their influence. Here we study the vicinal ZnO(10 1 ¯ 4) surface, rich in under-coordinated sites, using a combination of several expe
Responding to today's often transboundary emergencies, frequently characterized by unclear root causes and indistinct responsibilities as well as multiple actors, will require that responding actors come together to meet societal needs and solve problems arising in relation to those needs. In collective problem solving, representing the problem is crucial, especially in emergency situations, where
The Danish religious landscape has been significantly transformed, especially during the last three decades. This transformation is marked by the shift from near religious hegemony towards a much more diverse religious population. Originally, the Danish Lutheran state church was closely intertwined with the governmental administration of the country after the reformation in Denmark of 1536 and the
The minimization of a functional consisting of a combined L 1/L 2-data-fidelity term and a total variation term, named L 1-L 2-TV model, is considered to remove a mixture of Gaussian and impulse noise in images, which are possibly additionally deformed by some convolution operator. We investigate analytically the stability of this model with respect to its parameters and link it to a constrained m
This paper assesses water quality that is used for vegetable irrigation in Tamale Metropolis, Ghana. A mixed-method of research design was employed in this study to collect and analyze the data based on survey instruments. The paper found that Escherichia coli (E. coli) that is usually used as an indicator of water contamination and heavy metals exist in all taken water samples. The mean concentra
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess and compare the effects and complication rates of licensed bioengineered nerve conduits or wraps for surgical repair of traumatic peripheral nerve injuries of the upper limb. To compare effects and complications against the current gold surgical standard (nerve autograft).
It is generally accepted that China will be a great competitor to the Western industrialized countries in the twenty-first century. Is this a reasonable opinion? Is it true that China’s size and growth rate are important in measuring its potential as a competitor? Two questions should be considered. First, is the growth rate of the Chinese economy based on productivity gains? If economic growth is
