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Background Severe alpha-1-antitrypsin deficiency (AATD), phenotype PiZZ, is a risk factor for pulmonary emphysema and liver disease, but its effect on cancer risk is unknown. Our aim was to evaluate the risk and the risk factors for incident cancer in PiZZ individuals compared with the general population with known smoking habits. Methods A longitudinal study of PiZZ individuals (n=1,595) from the
Objective: While considerable focus has been placed on pain due to inflammation in psoriatic arthritis (PsA), less is reported on pain despite inflammation control. Here, we aimed to investigate the occurrence/predictors of persistent pain, including non-inflammatory components, after starting anti-tumour necrosis factor (anti-TNF) therapy. Method: Bionaïve PsA patients starting a first anti-TNF t
Progressive pulmonary fibrosis (PF) is a complex interstitial lung disease that impacts substantially on patients’ daily lives, requiring personalised and integrated care. We summarise the main needs of patients with PF and their caregivers, and suggest a supportive care approach. Individualised care, education, emotional and psychological support, specialised treatments, and better access to info
Previous research on post-war society emphasized structural violence with subsequent reconciliation processes. Researchers have focused on the importance of narratives, but they have neither highlighted narratives about reconciliation nor analyzed conditions for reconciliation in post-war interviews. This article tries to fill this gap by analyzing the stories told by survivors of the Bosnian war
Anestesiläkare rapporterades i en svensk studie ha en högre mortalitet än genomsnittet av läkare. Detta fynd har dock ej kunnat reproduceras i motsvarande studier i de övriga nordiska länderna. Likväl har det spekulerats i om den angivna överrisken bland svenska anestesiläkare kan relateras till gruppens jourarbete med höga krav, nattarbete och stress. Kunskapen om hälsoeffekter av läkares jourarb
Antibody microarray is a novel technology that will allow us to efficiently perform global proteome analysis. Performing rapid and multiplexed analysis on complex proteomes, such as human serum, targeting also low-abundant analytes will, however, place high demands upon the microarray design with respect to logistics, specificity and sensitivity. In this study, we have shown that non-purified affi
Surface temperature in internal combustion engines is of high interest when studying heat losses. Two approaches for retrieving the surface temperatures are thermocouples and Laser Induced Phosphorescence, LIP. This study aims to analyze LIP as a technique for measuring surface temperature in internal combustion engines. The motivation for this study is the need for accurate surface temperatures w
From the point of view of each individual’s sense-making, an organization is an emergent property of inter-individual sense-making processes and activities. The organization is a result of emergence from individual sense-making perspectives. A critically informed approach to research involves recognition / understanding of this emergence. Without the recognition of the uniqueness of each particula
Insulin secretion is controlled by the beta cell's metabolic state, and the ability of the secretory granules to undergo exocytosis increases during glucose stimulation in a membrane potential-independent fashion. Here, we demonstrate that exocytosis of insulin-containing secretory granules depends on phosphatidylinositol 4-kinase (PI 4-kinase) activity and that inhibition of this enzyme suppresse
Popular Abstract in Swedish Denna doktorsavhandling består av fyra fristående artiklar. Artiklarna har det gemensamt att de alla använder Bayesiansk ekonometri, i kombination med s.k. Markov chain Monte Carlo (MCMC) metoder, för att studera olika problem inom finansiell ekonomi. De första två artiklarna är ytterligare relaterade till varandra genom att de båda handlar om portföljvalsteori och skatThis PhD thesis consists of four separate papers. What these papers have in common is that Bayesian Econometrics, in combination with Markov chain Monte Carlo (MCMC) methods, is applied to study various problems in financial economics. The first two papers are further related in that they both deal with portfolio selection and estimation risk, as are the last two papers in that they both deal with
We propose a method for detection of the degree of infection in the paranasal sinuses utilizing a previously published method whereby the viscosity in a sealed container may be measured using an ultrasound Doppler method. As ultrasound propagates in a liquid medium, due to attenuation, the resulting pressure gradient will cause the liquid to move in the propagation direction - the wellknown effect
Denna uppsats tar sin utgångspunkt i säkerhetsrådets paralys till följd av vetorätten i relation till Rysslands invasion av Ukraina 2022. På flera håll i den internationella debatten hörs kritiska röster angående säkerhetsrådets, och därmed i praktiken hela FN:s, passivitet till följd av säkerhetsrådet oförmåga att agera i enlighet med sin befogenhet enligt framför allt FN-stadgans kapitel sju. The background and the main question of this essay derives from the paraly-sis of the Security Council as a result of the use of the veto in relation to the Russian invasion of Ukraine in 2022. In the international discussion, critical voices have been raised against the Security Council's and thus the entire UN's inefficacy following the Security Council’s inability to act in accordance w
Handelsresandeproblemet (the Traveling Salesman Problem, TSP) är ett välkänt optimeringsproblem som kan vara utmanade att lösa även för dagens mest kraftfulla datorer. Problemet är enkelt att formulera: en handelsresande ska hitta den kortaste vägen för att besöka N städer och sedan återvända till staden hen startade i. Svårigheten härstammar från att när antalet städer ökar i problemet, ökar ocksThe traveling salesman problem (TSP) is a well-known computationally hard problem often used to benchmark new optimization algorithms. With recent advances in the field of quantum computing, quantum optimization algorithms are emerging as promising new ways to potentially solve such problems that remain difficult for classical computers. However, most modern quantum processing units (QPUs) still l
Title: Mapping the usage of returnable packaging material and a proposal for improvements - a Case Study at Haldex AB in Landskrona Author: Annika Jönsson Supervisor: Enes Hasic & Anders Pålsson, Haldex AB, Landskrona Eva Berg, Department of Industrial Management and Logistics, Division of Engineering Logistics, Faculty of Engineering, Lund University Examiner: Jan Olhager, Department of Indus
In 2005 the United Nations International Law Commission released the report Fragmentation of International Law: Difficulties arising from the diversification and expansion of International Law. Although fragmentation of international law had been a topic of discussion long before 2005 the report really made the debate take off, becoming one of the most debated issues in recent years among internat
Nowadays, organizations pursue their aims in a context of distributed collaboration, creating a need not only for supporting ICT systems, but for a hu-man-centred focus in which individual and group sense-making and learning are supported by appropriate toolsets. We argue that development of such toolsets re-quires an open systems approach. This paper discusses one example: non-competitive benchma
Svensk sammanfattningKraftiga förluster av pollinerare är oroande och det har talats om risken för att en pollineringskris ska uppstå, med konsekvenser för både människor och miljö. De flesta blommande växter och tre av fyra odlade grödor är nämligen insektspollinerade (Box 1). Minskningarna hänger ihop med det moderna jordbrukets utveckling. Många gamla hagmarker och ängsmarker där bin och fjärilAgricultural intensification and associated loss of semi-natural grasslands, has resulted in reduced landscape heterogeneity. A concomitant loss of forage and nest sites for pollinating insects has driven declines across several pollinator taxa. Because 75% of the cultivated crops and more than 85% of the flowering plant species are insectpollinated, concerns have been raised that the pollinator d
Autoimmune (type 1) diabetes mellitus is a chronic disease without a cure. It affects primarily young people but may be diagnosed at any age. Strong genetic susceptibility characterizes the most common form of autoimmune diabetes in children younger than 18 years of age. Autoimmune diabetes is generally assumed to be hereditary, although the majority of patients do not have a family history of aut
Background: The longevity for people with intellectual disability (ID) has significantly increased in developed countries during the past decades. Consequently, the incidence of cancer is expected to increase in this group. The aim of the present study was to investigate the prescription of pain medication in older cancer patients with intellectual disability (ID) compared to older patients in the
Entre 2009 et 2011 nous avons mené un projet de recherche à l’université de Lund (Suède) intitulé L'âge de début d’acquisition et le développement linguistique en français (Schlyter/Granfeldt) dont le but était de comparer le développement linguistique du français de trois groupes d’enfants : des enfants monolingues (L1), des enfants bilingues simultanés (2L1) et des enfants ayant le français comm
