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The past years have seen the rise of genomic biobanks and mega-scale meta-analysis of genomic data, which promises to reveal the genetic underpinnings of health and disease. However, the over-representation of Europeans in genomic studies not only limits the global understanding of disease risk but also inhibits viable research into the genomic differences between carriers and patients. Whilst the
Parkinson’s disease (PD) is a complex, progressive neurological condition that impacts daily life and reduces life satisfaction (LS). To achieve and maintain high LS, persons with PD (PwPD) must go through a process of change to adapt to their new life situation. However, our knowledge about this process is very limited. The aim of this study was to investigate the process of change, and the main
In many Gram-positive bacteria, the redox-sensing transcriptional repressor Rex controls central carbon and energy metabolism by sensing the intra cellular balance between the reduced and oxidized forms of nicotinamide adenine dinucleotide; the NADH/NAD+ ratio. Here, we report high-resolution crystal structures and characterization of a Rex ortholog (Gbs1167) in the opportunistic pathogen, Strepto
Translation termination in eukaryotes is governed by the concerted action of eRF1 and eRF3 factors. eRF1 recognizes the stop codon in the A site of the ribosome and promotes nascent peptide chain release, and the GTPase eRF3 facilitates this peptide release via its interaction with eRF1. In addition to its role in termination, eRF3 is involved in normal and nonsense-mediated mRNA decay through its
Purpose: Institutional and commercial web profiles that provide biobibliographic information about researchers are used for promotional purposes but also as information sources. In the latter case, the profiles' (re)presentations of researchers may be used to assess whether a researcher can be trusted. The article introduces a conceptual framework of how trust in researchers may be formed based on
Background: Functional head impulse test (fHIT) tests the ability of the vestibulo-ocular reflex (VOR) to allow visual perception during head movements. Our previous study showed that active head movements to the side with a vestibular lesion generated a dynamic visual performance that were as good as during movements to the intact side. Objective: To examine the differences in eye position during
BACKGROUND: To describe visual field (VF) outcome in three adolescents with damage to the optic radiation and to focus on mechanisms that may compensate the practical functional limitations of VF defects.DESIGN: Descriptive, prospective multi-case study in a hospital setting.PARTICIPANTS: Three teenagers with cerebral visual dysfunction because of damage to the retro-geniculate visual pathways.MET
Efter att ha dominerat angloamerikansk filosofi under 1800-talets sista decennier kom idealismen att förlora sin ställning efter sekelskiftet, då övergången från viktorianska till modernistiska ideal, snabba sociala förändringar, ökad sekularisering och naturvetenskapens dominans tycktes kräva nytt filosofiskt tänkande. Vid andra världskrigets utbrott var idealismen utdöd och ersatt av den analytiAfter having dominated philosophical thought in Britain and the United States during the end of the nineteenth century, idealism was in steady decline by the outbreak of World War I. Its ideas and ideals seemed unsuited to face the transition from Victorianism to modernism and the rapid social changes of the post-war era. Its Anglo-American proponents—who were often liberals—were accused of indire
Nanoparticles in a biological fluid (plasma, or otherwise) associate with a range of biopolymers, especially proteins, organized into the “protein corona” that is associated with the nanoparticle and continuously exchanging with the proteins in the environment. Methodologies to determine the corona and to understand its dependence on nanomaterial properties are likely to become important in bionan
Anomaly detection is the process of identifying unexpected data samples in datasets. Automated anomaly detection is either performed using supervised machine learning models, which require a labelled dataset for their calibration, or unsupervised models, which do not require labels. While academic research has produced a vast array of tools and machine learning models for automated anomaly detecti
This paper addresses Jem Bendell’s concept of “deep adaptation” in the Anthropocene through the lens of everyday urban practices in contemporary Northern Europe. It proposes that this “deep adaptation” should be defined less in relation to a socio-ecological “collapse” and more through everyday occurrences in present- day urban environments.Entering into a critical conversation with Bendell’s conc
The millimeter-wave phased array in the user equipment (UE) for 5G communication is studied in this letter. In particular, the body effect on the phased array in the UE at 15 GHz is investigated with the 3-D measurement data, and its impact on some key parameters for phased array in the UE, such as the total scan pattern, the coverage efficiency, and the probability of detection, are analyzed.
An inclusive search for a new-physics signature of lepton-jet resonances has been performed by the ATLAS experiment. Scalar leptoquarks, pair-produced in pp collisions at s √S13 TeV at the large hadron collider, have been considered. An integrated luminosity of 3.2 fb−1, corresponding to the full 2015 dataset was used. First (second) generation leptoquarks were sought in events with two electrons
This study compares the performance of simulated shallow ponds vegetated with Lemna minor L. under controlled and semi-natural conditions for the treatment of simulated wastewater containing textile dyes. The objectives were to assess the water quality outflow parameters, the potential of L. minor concerning the removal of chemical oxygen demand (COD) and four azo dyes (Acid blue 113, reactive blu
All motile organisms need to organize their motor output to obtain functional goals. In vertebrates, natural behaviors are generally composed of a relatively large set of motor components which in turn are combined into a rich repertoire of complex actions. It is therefore an experimental challenge to investigate the organizational principles of natural behaviors. Using the relatively simple locom
The risk among asphalt workers of developing adverse health effects may increase due to their occupational exposure. One area of special concern arises when rubber granules are mixed into bitumen to enhance asphalt properties. This research characterizes and compares bitumen and rubber bitumen regarding the emissions of and workers' exposure to particulates, polycyclic aromatic hydrocarbons (PAHs)
Cities are key actors in reducing both the causes of climate change (mitigation) and its impact (adaptation), and many have developed separate mitigation and adaptation strategies and measures. However, in order to maximize outcomes, both scholars and practitioners are increasingly calling for more integrated and synergetic approaches. Unfortunately, related research remains scarce and fragmented,
The aim of this report is to establish recommendations for reviewing, reporting, and conducting research during the post-resuscitation period in hospital. It defines data that are needed for research and more specialised registries and therefore supplements the recently updated Utstein template for resuscitation registries. The updated Utstein template and the out-of-hospital "Chain of Survival" d
