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Regulation of rod phototransduction machinery by ciliary neurotrophic factor

Ciliary neurotrophic factor (CNTF) promotes photoreceptor survival but also suppresses electroretinogram (ERG) responses. This has caused concerns about whether CNTF is detrimental to the function of photoreceptors because it is considered to be a potential treatment for retinal degenerative disorders. Here we report that the suppression of ERG responses is attributable to negative regulation of t

Protein Complexity via Non-Native States: Binding, Stability, and Structural Studies of Calbindin D9k and HAMLET (Human alpha-lactalbumin Made LEthal to Tumor cells).

Popular Abstract in Swedish Kalcium är inblandat i många viktiga processer i kroppen. Kalciumbindande proteiner är viktiga i detta sammanhang. Det finns ofta en vattenmolekyl med på bindningsstället i proteinet och vi har studerat hur den påverkar bindningsegenskaperna. Kalcium är inblandat i många viktiga processer i kroppen. Kalciumbindande proteiner är viktiga i detta sammanhang. Jag har studeUsing optical spectroscopy, nuclear magnetic resonance (NMR), and differential scanning Calorimetry (DSC), I have studied two different calcium binding proteins that can form kinetically trapped altered states. Calcium is very important in numerous biological processes such as blood coagulation, signal transduction, muscle contraction and bone formation. Calcium binding to proteins regulates these

Making Pairs

This thesis makes a contribution to matching theory. It consists of five self-contained papers. It is a study predominately on the existence of stable outcomes. These are desirable both from a practical and a theoretical standpoint. Matching theory has grown in importance in recent years following its successful applications to, for instance, kidney exchange, the National Resident Matching Program

Interaction between cyclists and right turning motor vehicles at signalised intersections : Field observations and interviews with cyclists

The aim of the study presented in this report was to investigate what cues cyclists use to interpret the intention of motor vehicles (MVs) they interact with. This was done with help of on-site observations of cyclists’ interactions with motor vehicles (MV) at signalised intersections with different bicycle infrastructure facilities: A) no dedicated cycle facility, B) cycle lane and C) cycle path.The aim of the study presented in this report was to investigate what cues cyclists use to interpret the intention of motor vehicles (MVs) they interact with. This was done with help of on-site observations of cyclists’ interactions with motor vehicles (MV) at signalised intersections with different bicycle infrastructure facilities: A) no dedicated cycle facility, B) cycle lane and C) cycle path.

Constructing the national innovation system in Rwanda: efforts and challenges

The building of sustainable innovation capabilities in Africa requiresan innovation system capable of producing, disseminating andusing new knowledge. This paper assesses the process ofconstructing the National Innovation System (NIS) in Rwanda. It isposited that consensus on and acceptance of the concept of NISamong stakeholders is crucial in the early process of constructingan efficient and dynaThe building of sustainable innovation capabilities in Africa requires an innovation system capable of producing, disseminating and using new knowledge. This paper assesses the process of constructing the National Innovation System (NIS) in Rwanda. It is posited that consensus on and acceptance of the concept of NIS among stakeholders is crucial in the early process of constructing an efficient an

A Naturalistic Perspective on Knowledge How : Grasping Truths in a Practical Way

For quite some time, cognitive science has offered philosophy an opportunity to address central problems with an arsenal of relevant theories and empirical data. However, even among those naturalistically inclined, it has been hard to find a universally accepted way to do so. In this article, we offer a case study of how cognitive-science input can elucidate an epistemological issue that has causeFor quite some time, cognitive science has offered philosophy an opportunity to address central problems with an arsenal of relevant theories and empirical data. However, even among those naturalistically inclined, it has been hard to find a universally accepted way to do so. In this article, we offer a case study of how cognitive-science input can elucidate an epistemological issue that has cause

Higher Education for Girls in North American College Fiction 1886-1912

Popular Abstract in Swedish Från 1865 och framåt öppnades i nordöstra U.S.A ett antal college där unga kvinnor kunde avlägga en icke yrkesinriktad akademisk examen. Efter några decennier använde några som utexaminerats från dessa institutioner sina erfarenheter i populära berättelser om studenter på college. Avhandlingen visar hur denna utbildning presenteras i skönlitterär form. Fokus ligger på Twenty years after Vassar College welcomed the first American female undergraduates in 1865, the experiences of women college students began to be fictionalized in so-called college stories. This thesis shows how higher education is presented in the novels, collections of short stories, and serialized stories for female readers published before the United States was involved in the First World Wa

Turning the Ship : The Transformation of DESY, 1993–2009

This article chronicles the most recent history of the Deutsches Elektronen-Synchrotron (DESY) located in Hamburg, Germany, with particular emphasis on how this national laboratory founded for accelerator-based particle physics shifted its research program toward multi-disciplinary photon science. Synchrotron radiation became DESY’s central experimental research program through a series of changesThis article chronicles the most recent history of the Deutsches Elektronen-Synchrotron (DESY) located in Hamburg, Germany, with particular emphasis on how this national laboratory founded for accelerator-based particle physics shifted its research program toward multi-disciplinary photon science. Synchrotron radiation became DESY’s central experimental research program through a series of changes

Medborgarskapande på olika villkor : Självbilder, skolkoder och syn på kunskap i den svenska gymnasieskolan

Citizens are not born, they are made. Based on fieldwork in two upper-secondary school classes in Sweden – an Introductory Programme class and a Social Science Programme class – this dissertation focuses on how pupils form their identities as citizens in a democratic society. Citizens are made in interaction with the society they inhabit, an interaction where power is always present. Although Swed

Entangled media histories : The value of Transnational and Transmedial Approaches in Media Historiography

The transnational and transmedial dimensions of media and communication throughout history have not always been adequately recognised. In this research report we propose the concept of entanglement as a means of better understanding the dynamic interconnectedness of media across semiotic, technological, institutional and political boundaries in history. Entanglement is a concept that can be employThe transnational and transmedial dimensions of media and communication throughout history have not always been adequately recognised. In this research report we propose the concept of entanglement as a means of better understanding the dynamic interconnectedness of media across semiotic, technological, institutional and political boundaries in history. Entanglement is a concept that can be employ

Utbildning för hållbar utveckling – en gigantisk utmaning för Utbildnings-Sverige

Statsmakterna kräver nu att verksamheterna vid Sveriges universitet och högskolor ska genomsyras av ett hållbarhetsperspektiv. Riksdagen har nu beslutat att dessa verksamheter ska ”främja en hållbar utveckling”. I regeringens Budgetproposition 2005/06:1 återfanns förslag till lag om ändring i högskolelagen. Där föreskrevs att 1 kap. 5 § högskolelagen (1992:1434) skall ha följande lydelse: Högskol

Iconoclasm. The destruction and loss of heritage reconsidered.

In 2001, when the Taliban decided to destroy numerous cultural artefacts, including two colossal Buddha statues, that they considered incompatible with their faith, a large outcry was heard across the Western world. From the UNESCO to the British Museum, and from the Dalai Lama to countless head of governments, all were united in condemning this act of ’cultural terrorism’ that was said to prove n

Sociala Medier - Bara en massa issues?

Denna fallstudie studerar och analyserar hur Arla bemöter negativa kommentarer på Instagramkontot Arla Sverige. Vi belyser hur Arla förhåller sig till teorier inom Is-sues Management i sin kommunikation på ett av sina Instagramkonton. Vi använder en netnografisk observation samt intervjumetod som insamlingsmetod. Den netnografiska metoden används för att samla in kommentarer från Instagramkontot AThis case study aims to investigate how Arla responds to negative comments posted to their social media in order to gain knowledge of how they take into consideration Issues Management in their social media communication. Through a netnographic observation and two in-depth interviews with Arlas press- and media manager we gather empirical material. The netnographic observation is used to gather co