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Internal combustion engine (ICE) fuel efficiency is a balance between good indicated efficiency and mechanical efficiency. High indicated efficiency is reached with a very diluted air/fuel-mixture and high load resulting in high peak cylinder pressure (PCP). On the other hand, high mechanical efficiency is obtained with very low peak cylinder pressure as the piston rings and bearings can be made w
Given the recent changes in how central banks use the tools they have at hand to control inflation and money supply this study aims to evaluate the effect that interest rate policy has had on IPO underpricing. More specifically, the effect that negative interest rate policies and quantitative easing has had on the size of the underpricing premium. To test these effects, we collected IPO data from
Considering the growing importance of environmental issues on the international political scene, the question arises as to how these issues are incorporated into the agenda and procedures of international organizations (IOs) and institutions. The World Trade Organization (WTO) - one of the largest IOs – has to handle a strong mandatory connection to global trade as well as an increasing environmen
BACKGROUND: Gut microbiota have been implicated in atherosclerotic disease, but their relation with subclinical coronary atherosclerosis is unclear. This study aimed to identify associations between the gut microbiome and computed tomography-based measures of coronary atherosclerosis and to explore relevant clinical correlates.METHODS: We conducted a cross-sectional study of 8973 participants (50
Electric power grids have a limited capacity for safe and reliable transfer of power. Due to the ongoing large-scale expansion of variable renewable energy sources, such as wind and solar, there is a growing need for rapid gridcapacity increase.This thesis explores methods for improving and expanding grid capacity through control of converter-interfaced energy resources, including wind and solar p
Purpose Visual interpretation of brain amyloid-β (Aβ) PET can be difficult in individuals with borderline Aβ burden. Coregistration with individual MRI is recommended in these cases, which, however, is not always available. This study evaluated coregistration with the early perfusion frames acquired immediately after tracer injection to support the visual interpretation of the late Aβ-frames in PE
We used immunochemistry to demonstrate expression of acetylcholine's nicotinic α7-receptor subtype in human colon cancer cell line HT-29. Moreover, RT-PCR and immunochemistry showed that choline acetyltransferase and acetylcholine esterase, the enzymes responsible for acetylcholine synthesis and degradation, respectively, localise in HT-29 cells. Bromoacetylcholine bromide, an inhibitor of choline
Abstract in UndeterminedThe purpose of this paper is to explore how discourse-analytic conceptual genealogy can be used as a complementary approach to broaden the understanding of archives in the ‘information age’. The main argument is that discourse analysis of the historical transformations of pivotal archival concepts can provide important insights into how archives understand and position them
The role of chemotherapy (CHX) in squamous cell carcinoma of the head and neck (SCCHN) has been expanding. Although combination chemotherapy regimens regularly produce significantly high response rates, meta-analyses show little benefit regarding final outcome. One way to improve induction CHX is to improve drug combinations and schedules for CHX. Cisplatin (CDDP) is one of the most active drugs i
In the first of two essays in this Journal, I seek to unify the historical geography of early modern 'European expansion' (Iberia and Latin America) with the environmental history of the 'transition to capitalism' (northwestern Europe). The expansion of Europe's overseas empires and the transitions to capitalism within Europe were differentiated moments within the geographical expansion of commodi
