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Impact of site-specific conjugation strategies on the pharmacokinetics of antibody conjugated radiotherapeutics
Antibody radionuclide conjugates are an emerging modality for targeted imaging and potent therapy of disseminated disease. Coupling of radionuclides to monoclonal antibodies (mAbs) is typically achieved by applying non-site-specific labelling techniques. With the ambition of reducing variability, increasing labelling efficacy and stability, several site-specific conjugation strategies have been de
A simulation-based approach for systematic analysis of workflow during the construction of in-situ concrete frames
Rebranding Politics: The Impact of Generative AI on Political Branding and Voter Trust
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Still leaders but less exceptional : The Nordic states and development assistance
The Nordic countries have been described as generous front-runners in their development assistance, making observers suggest the existence of a ‘Nordic Model’. They have been claimed to play a leadership role in a European and global context. Recently, however, this characterisation has been challenged due to changes in Nordic policies and in the external environment. We investigate the developmen
Simulation of System Brake Efficiency in a Double Compression-Expansion Engine-Concept (DCEE) Based on Experimental Combustion Data
The double compression-expansion engine concepts (DCEE) are split-cycle concepts where the compression, combustion, expansion and gas exchange strokes occur in two or more different cylinders. Previous simulation studies reveal there is a potential to improve brake efficiency with these engine concepts due to improved thermodynamic and mechanical efficiencies. As a continuation of this project thi
Reading Spaces : Original Audiobooks and Mobile Listening
Following ‘the audiobook boom’ of recent years, born-audio narratives have emerged: texts produced specifi cally for the audiobook format and intended for mobile audio consumption. Focusing on this category of works, this article examines how the audiobook draws attention to places and situations in which we read, and how these places, in turn, infl uence the content and experience of literary wor
Countercurrent Distribution of Lymphocytes from Human Peripheral Blood in an Aqueous Two-Phase System : I. Separation into Subsets of Lymphocytes Bearing Distinctive Markers’
Lymphocytes from human peripheral blood have been separated by countercurrent distribution in a charged aqueous two-phase system composed of Dextran T 500 and polyethylene glycol 6000 with a cell yield of 59–88% and viability above 90%. A highly reproducible partition pattern was seen with four distinct peaks. Lymphocytes with surface membrane immunoglobulin (SmIg) were located in the first part o
