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Development of Novel Therapies, Models, and Biomarkers for Osteoclast-Related Diseases

Osteoclasts are derived from hematopoietic stem cells (HSCs) and form upon stimulation of osteoclast precursors by macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor κΒ ligand (RANKL). Osteoclasts resorb bone by secreting hydrochloric acid, matrix metalloproteinases (MMPs) and cathepsin K. Failure of bone resorption or bone formation results in metabolic bone disOsteoclasts are derived from hematopoietic stem cells (HSCs) and form upon stimulation of osteoclast precursors by macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor κΒ ligand (RANKL). Osteoclasts resorb bone by secreting hydrochloric acid, matrix metalloproteinases (MMPs) and cathepsin K. Failure of bone resorption or bone formation results in metabolic bone dis

Turning rural knowledge into “nothing” or “something”

From the perspective of the Swedish education system, rural knowledge does not seem to be particularly important. Many young people in rural areas have deep and important knowledge that is invisible in school and during school time, both to teachers and to the young people themselves. This paper examines knowledge used in agriculture and animal husbandry, a type of knowledge that is particularly u

Snabblånemarknaden och konsumenten

Under 2006 introducerades snabblån på den svenska kreditmarknaden. Snabblån är ett mindre lån som betalas ut snabbare än traditionella lån och har oftast en kort återbetalningsperiod. Sedan 2006 har kritiska röster höjts mot låneformen. Snabblånen har präglats av godtyckliga kreditkontroller, höga räntor och fokusering på en redan utsatt konsumentgrupp. Låneformen har huvudsakligen kritiserats förHigh-cost credits were introduced on the Swedish credit market during 2006. High-cost loans are small loans that are paid out faster than traditional loans and usually have a shorter amount of time before payback is due. Since 2006, critics have raised their voices against this type of loan. High-cost loans have been characterized by deficient credit checks, high interest rates and a focus on an a

Incretin, insulinotropic and glucose-lowering effects of whey protein pre-load in type 2 diabetes: a randomised clinical trial

Aims/hypothesis Since protein ingestion is known to stimulate the secretion of glucagon-like peptide-1 (GLP-1), we hypothesised that enhancing GLP-1 secretion to harness its insulinotropic/beta cell-stimulating activity with whey protein pre-load may have beneficial glucose-lowering effects in type 2 diabetes. Methods In a randomised, open-label crossover clinical trial, we studied 15 individuals

Systemförvaltningsmodeller

Popular Abstract in Swedish Begreppet systemförvaltning började användas i början på 1970-talet. Ämnet har betydelse ur flera perspektiv. Systemförvaltningskostnaderna är som regel betydligt större än systemutvecklingskostnaderna, vilket kan veri¬fieras med flera undersökningar gjorda i olika länder och under en tidsperiod omfattande ett par decennier. Det vetenskapliga intresset för systemförvalt

Electronic Effects in Iridium Pincer Complexes : Structure, speciation and mechanistic pathways in dehydrogenation reactions

Iridium pincer complexes are among the most versatile catalysts for bond‑activation chemistry, yet their performance is often governed as much by off-cycle speciation and inhibition as by intrinsic reactivity. This thesis investigates how pincer ligand design influences the structure, dynamics, and catalytic behaviour of iridium complexes and their relevance to acceptorless dehydrogenation.Initial

Activation and Participation in Ecological Sound Art

Showing of two installations that result from an ecological sound art practice and its complex and radical modulation of performing/composing/curating within assemblages. The works spring out of an ecological-enactive approach, where through relational technique and fleshy listening the authors explore what the performative body can do; what connections and networks it creates across temporality a

Outsourcing of Organizational Routines : Knowledge, control, and learning aspects

Organizational routines that are critical to learning, flexibility, and adaptation explain the behaviour of the business organization. When organizational routines cross the boundary of the organization, variability and stability are affected. This study emphasizes organizational routines committed in specific outsourcing or insourcing situations to clarify the dynamics of organizational routines

From quality control to TQM, service quality and service sciences : a 30-year review of TQM literature

Purpose: This paper aims to review total quality management (TQM) literature in the past three decades to identify the quality related key terms, to analyse their linkage among the identified key terms and their developmental trends. Design/methodology/approach: Bibliometric and statistical methods are used to analyse article titles published in the Total Quality and Business Excellence journal du

Them & Us

In the quest for a better future some unemployed EU-citizens travel to Sweden. Finding a job is difficult and many are instead making a living begging. Cars, tunnels, parks and other shady places of our society become temporary homes. The authorities demolish some of these “camps” and the residents are accused for stealing bicycles, dogs and garden gnomes. Rumours and myths start to grow. In Swed

Economic Inequality and the Ecological Footprint: Time-Varying Estimates for the United States and France, 1962–2021

This paper studies the nexus between income and wealth inequality, and the ecological footprint in the United States and France from 1962 to 2021. Based on theoretical considerations, we allow the relationship to vary over time. We find some support for income inequality affecting the ecological footprint in the United States and that the relationship has changed over time. We find no such result