The Structure-Function Relationship and Evolution of Deoxyribonucleoside Kinases
The synthesis of deoxyribonucleoside triphosphates (dNTPs), building blocks of DNA, can be achieved by two different pathways in the cell. One is called de novo synthesis and the other is known as salvage pathway. The de novo pathway involves synthesis of dNTPs by utilizing basic molecules like sugars, amino acids, CO2, NH3, etc., while in the other pathway, dNTPs are formed by salvaging intra- or
