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The Human Pancreatic Islet Methylome and Its Role in Type 2 Diabetes

Islet dysfunction is central to the development and progression of type 2 diabetes (T2D). Epigenetic modifications are essential for establishing and maintaining cell identity and function in normal circumstances. Exposure to adverse environmental factors may alter the epigenome, and result in changes of gene expression and the resulting phenotype. The aim of this thesis was to analyze DNA methyla

What does it take to establish that a world is uninhabited prior to exploitation? – A question of ethics as well as science

If we find life on another world, it will be an extremely important discovery and we will have to take great care not to do anything that might endanger that life. If the life we find is sentient we will have moral obligations to that life. Whether it is sentient or not, we have a duty to ourselves to preserve it as a study object, and also because it would be commonly seen as valuable in its own

Kardiovaskulär forskning - immunitet och ateroskleros

Atherosclerosis is a disease characterized by chronic inflammation and fibrosis of the intima of large and medium sized arteries. Atherosclerosis in the coronary arteries is the most common cause of myocardial infarction and atherosclerosis in the carotids and other major arteries supplying the brain is the major cause of stroke. Cardiovascular diseases caused by atherosclerosis is the most common

Association of umbilical cord venoarterial differences, ΔpH, to morbidity and mortality up to 20 years of follow-up: a cohort study

IntroductionUmbilical cord blood measurement is the gold standard of evaluating neonatal metabolic status at birth. Dual sampling of cord blood vessels is clinical routine, yet the long-term value of venoarterial differences (ΔpH) is undetermined. The objective was to investigate the association of ΔpH, to long-term mortality and morbidity up to 20 years.Material and methodsThis was a retrospectiv

A methodology for assessing multiple hazards applied to Sweden

Despite extensive efforts through various international initiatives to reduce global warming, it has been determined that human induced climate change is here, that the present scale of disruption of the climate is unprecedented and will continue. Increasing weather volatility can be expected, which will most likely increase exposure to weather related hazards, e.g. wildfires, flooding. The aim of

A Dipole Model for High Energy QCD

This thesis considers a model of high energy particle collisions. The model is based on the so called BFKL formalism which is valid only at low x, that is collisions at very high energies, such as at the LHC. The intial state of the incoming particles are simulated by colour dipoles in transverse space evolved through rapidity. With this approach, all fluctuations are dynamically described, allowi

IFRS 3 - Ett fortsatt problem

Title: IFRS 3 – a continuous problem. A study of the standard's development Seminar date: June 1 2012 Course: FEKH95, Degree Project Undergraduate level, Business Administration, Undergraduate level, 15 University Credits Points (UPC) or ECTS-cr Authors: Henric Hammarbro, Anders Jeppsson, Gustav Rybrink Advisor: Erling Green Key words: IFRS 3, goodwill, business combinations, subjectivity, mat

Co-production for improving social housing programmes

The city of Helsingborg in Sweden has since 2010 been conducting a development work of its social housing programme. The city has built up a Housing First service, which today comprises 60 tenants, and has good results. Through two pilot projects, the city has also tried to develop the other parts of the social housing programme that previously was built on the staircase model. The ambition was toThe city of Helsingborg in Sweden has since 2010 been conducting a development work of its social housing programme. The city has built up a Housing First service, which today comprises 60 tenants, and has good results. Through two pilot projects, the city has also tried to develop the other parts of the social housing programme that previously was built on the staircase model. The ambition was to