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Chronic myeloid leukemia (CML) is a myeloproliferative disorder caused by clonal proliferation of primitive hematopoietic stem cell. The median age at diagnosis is 55 to 60 years with less than 10% of patients younger 20 years. Incidence of CML in children in the Czech Republic is 0.106 cases/100 thousands per year. Here we report outcome of 38 pediatric patients (median age 12.5 years; range 1.8
The Ukrainian Shield and Voronezh Crystalline Massif constitute the Sarmatian segment of Baltica. Here, only a few mafic-ultramafic dykes and layered intrusions have been dated, recording early Statherian (ca. 1800–1750 Ma) ages. We have determined new U-Pb baddeleyite ages for the Novogol sill (1789 ± 2 Ma) and the Gremyachye intrusion (1781 ± 7 Ma), which fall within the previously established a
The use of the magnetic-field-induced transition (MIT) in Fe X for the measurement of the magnetic field strength in the solar corona has been discussed and demonstrated in a number of recent studies. This diagnostic technique depends on, among other conditions, the accuracy of the atomic data for Fe X. In the present work, we carry out a large-scale calculation for the atomic properties needed fo
Locally adapted ecotypes can constitute an important part of the biodiversity, especially in young floras with few endemic species. However, the origins, distinctness and conservation value of many ecotypes remain uncertain because genetic data are lacking or no common-garden study has been carried out. In the present study, we evaluated the distinctness and genetic structure of a phenotypically d
Background: Although alcohol use disorder (AUD) runs strongly within families, studies examining the impact of rearing environment, unconfounded by genetic effects, are rare and, to date, contradictory. We here seek to conduct such a study using an adoptive co-sib control design. Methods: Defining high-risk as having 3/41 biological parent with an externalizing syndrome (AUD, drug abuse or crime),
The widespread occurrence of lower Eocene chert and porcellanite has been viewed as a major paleoceanographic issue since the advent of ocean drilling, and both biotic and abiotic forcings have been proposed to explain it. We present a reconstruction of indurated siliceous sediment (ISS) and preserved biosiliceous sediment (PBS) occurrences in the Atlantic Ocean through the Paleocene and Eocene (~
Type 1 diabetes (T1D) is an autoimmune disease associated with the destruction of pancreatic β cells and genetically linked to human leukocyte antigen (HLA) class II DR3-DQ2 and DR4-DQ8 haplotypes. The +49A/G polymorphism of the immunoregulatory cytotoxic T-lymphocyte antigen 4 (CTLA-4) gene is also associated with T1D. Genetic and environmental risk factors precede the onset of T1D, which is char
The first part of this paper discusses how Jesus is presented as a leader in the call narratives in the Gospel of Matthew (4.18–22). By making use of a biographical-narrative reading of Matthew, which takes the biographical genre seriously and pays attention to the narrative development of the story, and modern understanding of leadership, mainly by making use of transformational leadership theori
This article explores the relationship between statelessness and refugeeness over time and space. It does so by drawing on how Palestinian refugees from Syria in Sweden navigate the various stateless and refugee labels imposed upon them before, during and after their flight from Syria to Sweden. Standpoint theory was deployed as the basis for understanding how this group of stateless refugees rela
This chapter responds to the following question: what substantive positive obligations did the Court formulate in Verein KlimaSeniorinnen Schweiz under Article 8 ECHR that can actually guide the future conduct of States? To frame it even more specifically, what is the content of these positive obligations? More precisely, this content is clarified through the lens of the standard of causation. Cau
The Swedish Society of Paediatric Infectious Diseases worked with paediatric societies for emergency medicine, anaesthesia, and intensive care to produce the 2025 recommendations for the initial management of suspected sepsis. They cover 28 days of corrected age to 18 years, but exclude immunodeficiency, immunosuppression, and suspected meningitis. Suspicion of sepsis and sepsis-associated shock i
BACKGROUND: Patients presenting with an acutely painful swollen joint represent a diagnostic challenge. We aimed to develop a clinical prediction model for septic arthritis (SA) in the adult native knee.METHODS: We screened all synovial cultures in south Sweden in 2020 and 2021. We included cultures taken in the emergency department from adults' native knees where SA was considered a differential
Changes in drug use in the general population during the COVID-19 pandemic and their long-term consequences are not well understood. We employed natural language processing and machine learning to analyse a large dataset of self-reported rates of and reasons for drug use during the pandemic, along with their associations with anxiety, depression and substance use problems post-pandemic. Our findin
