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This paper presents a practical risk analysis method for critical, large-scale IT systems in an organisation. The method is based on reliability block diagram modelling and was adapted to fit the requirements of governmental organisations and to reduce the effort required to capture complex failure behaviour. Through the use of different failure categories the risk analysis can be simplified, the
The thesis consists of an introduction and the following four papers: Paper I: Using resultants for SAGBI basis verification in the univariate polynomial ring. Authors: Anna Torstensson, Victor Ufnarovski and Hans Öfverbeck. Abstract: A resultant-type identity for univariate polynomials is proved and used to characterise SAGBI bases of subalgebras generated by two polynomials. A new equivalent
Many lines of evidence suggest that the Parkinson’s disease (PD)-related protein α-synuclein (α-SYN) can propagate from cell to cell in a prion-like manner. However, the cellular mechanisms behind the spreading remain elusive. Here, we show that human astrocytes derived from embryonic stem cells actively transfer aggregated α-SYN to nearby astrocytes via direct contact and tunneling nanotubes (TNT
Aim: The primary objective of this study was to describe demographics and end-of-life treatments of children with cancer at a government tertiary cancer center in India. Methods: A retrospective review was undertaken of medical charts of all children younger than 18 years, who died as inpatients while undergoing treatment at the pediatric oncology department between April and September 2016. Data
Quantitative evaluations are valuable in the strive for improvements and asserting quality. However, the field of Command & Control (C2) evaluations are hard to navigate, and it is difficult to find the correct measurement for a specific situation. A comprehensive Scoping Study was made concerning measurements of C2 performance and effectiveness. A lack of an existing appropriate framework for
Treatment with anti-CD20 antibodies is only moderately efficient in chronic lymphocytic leukemia (CLL), a feature which has been explained by the inherently low CD20 expression in CLL. It has been shown that CD20 is epigenetically regulated and that histone deacetylase inhibitors (HDACis) can increase CD20 expression in vitro in CLL. To assess whether HDACis can upregulate CD20 also in vivo in CLL
Since the 1980’s, additive manufacturing (AM) has gradually advanced from rapid prototyping applications towards fabricating end consumer products. Many small companies may prefer accessing AM technologies through service providers offering production services as result-oriented Industrial Product-Service System (IPSS) rather than investing in their own production line. This study investigated pot
Very few people around us know the meaning of the word cavitation, except from those who saw the movie "The Hunt for Red October" and can relate cavitation to Sean Connery in a submarine. Some of them know that it corresponds to the formation of bubbles, due to a pressure drop, and causes erosion and noise. However, cavitation is much more complex. A large amount of research work has been done ove
Earlier studies have shown that while free-viewing images people tend to gaze at regions with a high local density of bottom up features such as contrast and edge density. In particular, this tendency seems to be more emphasized during the first few fixations after image onset. In this paper, we present a new method to investigate how gaze locations are chosen by introducing varying image resoluti
The proposed algorithm aims at helping diabetic patients which use multi-dose injection (MDI) therapy to determine the dose and time of insulin and glucose intakes to stabilize their blood glucose (BG) concentration. The objective is to spend most of the time in normal BG range (70-180 mg/dl). The control was done by minimizing the risk of hypo- and hyperglycemia over the doses and times of insuli
Many scholars and philosophers inspired by Antiquity, have commented upon a transformation of lived religion and a changing picture and technology of the Self during Late Antiquity. The Nag Hammadi Library contains a diverse body of thought and it is here argued that these texts are found in the epicentre of Late Antique conversion of religion and Self, containing important illustrations of new em
