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Engineered allele substitution at PPARGC1A rs8192678 alters human white adipocyte differentiation, lipogenesis, and PGC-1α content and turnover

Aims/hypothesisPPARGC1A encodes peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α), a central regulator of energy metabolism and mitochondrial function. A common polymorphism in PPARGC1A (rs8192678, C/T, Gly482Ser) has been associated with obesity and related metabolic disorders, but no published functional studies have investigated direct allele-specific effects in adipocyte bi

Aesthetic Regulations of Objectionable Representations: A Semiotic Approach to Memorials and Materialised Religious Thought.

In acts of memorialisation, the objects that ”help” people get into contact with (their memory of) the deceased – like gravestones, personal collections of the deceased’s paraphernalia, objects placed at sites of sudden death, etc. – are often strictly regulated, differently in different cultures. At ”wrong” spots in the urban environment for instance, memorial places can thus be regarded as highl

The Transition From Rookie to Genuine Nurse: Narratives From Swedish Nurses 1 Year After Graduation

This article describes nurses' experiences during their first year after graduation, based on the qualitative content analysis of eight interviews. The results show that the nurses experienced a transition from "being a rookie," including being accepted as a member of the team and respected as a colleague, to "becoming a genuine nurse," including the feeling of being able to shoulder responsibilit

The Poem as Concert. Lidner, Oxenstierna and the Unity of the Long Poem

This article adresses the problem of literary unity as is is posed by two late eighteenth century long poems, "Året 1783" by Bengt Lidner and Skördarne by Johan Gabriel Oxenstierna. By investigating the relations between poetry, poetics and practical criticism it seeks to document a situation in which new poems failed to achieve the kind of unity found in the traditional long poem, i.e. the epic.

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Abstract in German A complete documentation of the castles in SE Denmark