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The transcription factor, X-box Binding Protein-One (XBP1), controls the development and maintenance of the endoplasmic reticulum (ER) in multiple secretory cell lineages. We show here that Hepatocyte Nuclear Factor 4-alpha (HNF4α) directly induces XBP1 expression. Mutations in HNF4α cause Mature-Onset Diabetes of the Young I (MODYI), a subset of diabetes characterized by diminished GSIS. In mouse
BACKGROUND: The development of persistent itchy nodules at the injection site following hyposensitization therapy with aluminium-precipitated antigen extract has been described in several reports. Occasionally, contact allergy to aluminium has been reported in individuals with such nodules. OBJECTIVES: To investigate if hyposensitization therapy can induce contact allergy to aluminium and examine
BACKGROUND: Previous studies have observed decreased serum CRP levels in patients with established Alzheimer's disease (AD) compared to controls or other diagnostic groups of elderly patients with mental illness. METHODS: We have investigated the relation between CRP level and the severity of AD as assessed by cognitive function, brain imaging and survival time. RESULTS: Patients with AD showed ov
Although several studies have reported on the anti-tumoural properties exerted by 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoAR) inhibitors (statins), the in vivo expression of HMG-CoAR in human cancer has been considerably less investigated. In our study, we examined the immunohistochemical expression of HMG-CoAR in 511 incident breast cancers within the Malmö Diet and Cancer Study in
We investigated return of spontaneous circulation and of cerebral oxygenation after asphyxia-induced cardiac arrest, using ventilation with air, throughout, or with 100% oxygen for a shorter or longer period. Arterial pressure, heart rate, regional cerebral oxygen saturation (CrSO2) and brain tissue oxygen tension (PbtO2) were measured in one day old piglets that were hypoventilated with air and l
The purpose of this thesis is to examine the level of conict in the media between the government and the opposition at dierent time periods, and specically regarding EU policies. Opposition towards policy is a crucial ingredient in democratic systems of government that do not only allow the people to send dierent personalities to represent them in government, but rather dierent policy agendas that
The aim of this study was to investigate how development have affected access to sustainable livelihood capitals and how the perceived access to these capitals have changed in the past decades in Dravuwalu, a coastal society in Fiji. A case-study was conducted in the village of Drawuvalu. Data was gathered through semi-structured interviews and observations. The composition of livelihoods at the t
Can strategic thinking be taught? Randomized experiments were organized to estimate the effect of information nudge on strategic decisions. The information nudge consisted of seeing a short text and a picture with an explanation related to game theory. Test subjects played two games: a p-beauty contest game and a variable-sum game. The main finding was surprising; the treatment was related to answ
Purpose: The purpose of this thesis is to critically explore how a regulatory, community and organizational stakeholder perceive their role in the context of sustainability reporting as well as identify convergence and divergence between these different stakeholder perceptions. Methodology: We chose a qualitative-abductive approach to our case study of sustainability reporting by interviewing th
Seminar date: 2018-05-31 Course: BUSN79 Business Administration: Degree Project in Accounting and Finance, 15 credits Authors: Linnea Lövgren and Magdalena Stevens Advisor: Amanda Sonnerfeldt Five key words: Professional service firms (PSFs), value creation, technological development, competence, audit. Purpose: The overall purpose of this thesis is to provide deeper knowledge and provide a c
Alltsedan internets uppkomst har upphovsrätten tvingats till modernisering för att kunna hantera situationer där upphovsrättsligt skyddat material sprids över nätet på nya sätt i större omfattning än tidigare. Genom fildelning, streaming och delning av material via sociala medieplattformar kan skyddade verk spridas till stora grupper online med enkelhet. I takt med detta behov av modernisering på Ever since the rise of the internet, the copyright legislation has been forced to modernize to be able to cope with situations where copyright protected materials are spread across the internet in new ways and in a greater magnitude than before. Through file sharing, streaming and sharing of material via social media platforms protected work can easily be spread to large groups. As part of the eff
Introduction: Although Alzheimer’s disease (AD) is associated with early death, its life expectancy differs greatly between patients. A better understanding of this heterogeneity may reveal important disease mechanisms underlying the malignancy of AD. The aim of this study was to examine the relation between AD pathologies and early death in AD caused by dementia. Methods: At a memory clinic, 247
The tyrosine kinase inhibitor dasatinib exerts immunosuppressive effects on T-cells and NK-cells in vitro. However, in some dasatinib-treated leukemia patients, clonal lymphocytosis with large granular lymphocyte (LGL) morphology develops, and this is associated with enhanced therapeutic responses. To elucidate the mechanistic basis for this paradoxical observation, we conducted detailed phenotypi
Aquaporin-9 (AQP9) is a membrane protein channel that is permeable to a range of small solutes, including glycerol, urea and nucleobases. Expression of AQP9 in normal brain is limited, while widespread AQP9 expression has previously been reported in human glioblastoma. However, the specific cellular expression of AQP9 in glioblastoma remains unclear. In this study, we have examined microarrays to
This thesis empirically investigates the question if US firm’s capital structures are stable over longer periods of time and which firm characteristics drive optimal leverage. The analysis is based on a Compustat panel data sample consisting of 2,900 US firms between 1985 and 2016. After analyzing the stability of firm’s capital structure via a “narrow band” and a “relative bucket approach” an err
Purpose The purpose of this thesis is to contribute with knowledge on consumer identity in a social media setting and how companies can utilize this behaviour for effective marketing. Method The thesis adopts a constructivist perspective on how we interpret our interviewees, the reality and our own research role. The interviews have been inspired by both ethnographic and a phenomenological appro
Using data from 159 participants (Mage = 27.11 years; SD = 6.47; 55% men), we investigate the relationships between personality traits, acculturation towards heritage and mainstream culture, and sociocultural adaptation among non-Western immigrants in Sweden. A series of regression analyses have shown conscientiousness and agreeableness significantly related to heritage culture identification, whi
