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The influence of joint degeneration on the biomechanical properties of calcified cartilage and subchondral bone plate at the osteochondral junction is relatively unknown. Common experimental difficulties include accessibility to and visualization of the osteochondral junction, application of mechanical testing at the appropriate length scale, and availability of tissue that provides a consistent r
As temperatures decrease in autumn, vegetation of temperate and boreal ecosystems increases its tolerance to freezing. This process, known as hardening, results in a set of physiological changes at the molecular level that initiate modifications of cell membrane composition and the synthesis of anti-freeze proteins. Together with the freezing of extracellular water, anti-freeze proteins reduce pla
Type 2 diabetes mellitus is characterized by a low-grade inflammation; however, mechanisms leading to this inflammation in specific tissues are not well understood. The eye can be affected by diabetes; thus, we hypothesized that inflammatory changes in the eye may parallel the inflammation that develops with diabetes. Here, we developed a non-invasive means to monitor the status of inflammatory de
One strategy to achieve coordination of care for older people with complex care needs is the establishment of shared care plans. The aim of this study was to explore the process of establishing a shared care plan from the perspective of elderly people and their next of kin. Data were collected via 12 semi-structured interviews with 12 older persons targeted in joint care planning and 11 next of ki
Systemic lupus erythematosus (SLE) is an autoimmune disorder with heterogeneous clinical presentation and complex etiology involving the interplay between genetic, epigenetic, environmental and hormonal factors. Many common SNPs identified by genome wide-association studies (GWAS) explain only a small part of the disease heritability suggesting the contribution from rare genetic variants, undetect
Technical assistance to public sector organisations is a much-debated topic and showcases a considerable size in contemporary international development assistance. Yet, the empirical evidence base on which factors contribute to the outcomes of projects within this field is surprisingly slim and diffuse. Particularly, the mechanisms through which different factors affect project outcomes remains un
Herpes Simplex Virus type 1 (HSV-1) is a virus infecting over 90 % of the population. It causes latent infections in nerve cells and can upon reactivation travel along the neurons and cause lytic infections with painful blisters as a result. HSV-1 infects multiple cell types, fibroblasts and T-cells among others. During infection HSV-1 is known to downregulate the transcription of many of the gene
Människor skapar emotionella band till vissa platser, s.k. platsanknytningar, vilka anses starka nog att påverka samt påverkas av deras identiteter. Banden har undersökts för många typer av platser, däribland religiösa platser, men det är hittills oklart vad pilgrimers platsanknytning korrelerar med och varför. Denna studie syftar därför till att jämföra katolska och evangelikalt protestantiska pi
The wax on the stem and leafs of the barley (Hordeum vulgare L.) plant has a protective function and is produced by the cells on the plant's outer surfaces. There are several available barley mutants where the wax production has been stopped. Four mutants are the single-site mutants cer-c.36, cer-q.42, ceru. 21 and the deletion mutant cer-cqu.724. We phenotyped 636 barley plants and collected
The European Union (EU) has long suffered from a democratic deficit, something that has been highlighted many times by politicians, media and citizens alike. The EU has in turn tried to better its democratic standing by increasing the power of the European Parliament (EP) through the Treaty of Lisbon in 2009. This has however not increased turnout in the EP elections substantially, as only the lat
The aim of this thesis is to explore the interrelation of employer branding and employee engagement in the context of corporate restructuring and organizational change. Our research follows an interpretative and abductive approach. We have conducted a qualitative case study with Ingka Centres as our case company. This thesis contributes to the literature on employer branding and employee engagemen
Early-life lead exposure impairs neurodevelopment and later exposure affects the cardiovascular system. Lead has been associated with reduced global 5-methylcytosine DNA methylation, suggesting that lead toxicity acts through epigenetic mechanisms. The objective of this study is to clarify how early-life lead exposure alters DNA methylation of specific genes, using an epigenomic approach. We measu
Objective: Subjective cognitive decline (SCD) is associated with an increased risk of Alzheimer's Disease (AD). Early disease processes, such as amyloid-β aggregation measured with quantitative PET, may help to explain the phenotype of SCD. The aim of this study was to investigate whether quantitative amyloid-β load is associated with both
The envisioning of a Scandinavian Theme Park to be located outside Malmö, close to the anchor of the bridge to Copenhagen, is here discussed in relation to the culture and heritage that was represented in the design proposals. The public presentations of the project were directed by a small group of visionaries who were given space and economic support by the political leadership of Malmö City, in
The International Agency for Research on Cancer has recently classified occupational exposure as a firefighter as carcinogenic (group 1A). Even though the occupation of firefighter is associated with high exposure to pollutants, it is challenging to carry out exposure studies to assess health risks due to the extreme conditions associated with firefighting. Routine monitoring of occupational expos
