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IMPORTANCE: The value of microRNAs (miRNAs) as biomarkers has been investigated in various clinical contexts. Initial small-scale studies suggested that miRNAs might be useful indicators of outcome after cardiac arrest. OBJECTIVE: To address the prognostic value of circulating miRNAs in a large cohort of comatose patients with out-of-hospital cardiac arrest. DESIGN, SETTING, AND PARTICIPANTS: This
In the course of 2000s, the region of Campania in southern Italy and its capital city Naples became global icons of waste mismanagement after the images of piles of rubbish occluding their urban areas hit the headlines. Conventional explanations, in Italy and elsewhere, pointed to administrative failure, cultural backwardness and mafia infiltration as the main causes of waste mishandling. In the s
This work focuses on the investigation on both local and global dielectric properties for a random wound single tooth winding, which represents a segment of the in-field electrical machine used on an Hybrid Wheel Loader. Finite Element Analysis (FEA) is used to predict the temperature stress while loading and illustrate the influences of dielectric properties (i.e. conductivity and dielectric cons
This dissertation aims at advancing the knowledge about the role of the labour market in the process of the technology-induced economic transformation, taking into account the variety of factors involved at micro-, meso-, and macro-levels of the economy and at different geographical scales. Empirically, the dissertation investigates the co-evolutionary dynamics of industrial restructuring and work
To reduce greenhouse gas (GHG) emissions and help mitigate climate change, urban water systems need to be adapted so that electrical energy use is minimised. In this study, energy data from 2011 was used to quantify energy use in China’s urban water supply sector. The objective was to calculate the energy co-benefits of urban water conservation policies and compare energy use between China and oth
A combination of mesoscale hydrodynamic simulations and microfluidic experiments are used to explore the use of cells' mechanical and dynamical properties as biomarkers for separation. Dynamic behaviour of red blood cells (RBCs) within deterministic lateral displacement (DLD) devices is investigated within various array geometries and for different viscosity contrasts between the intra- and extra-
Mesoscopic simulations with two-dimensional (2D) models have been performed to elucidate the dynamics of deformable red blood cells (RBCs) in deterministic lateral displacement (DLD) devices. Several shapes of posts, including circular, diamond, square and triangular structures and RBCs with different rigidities are considered. In comparison to rigid particles, the deformable RBCs exhibit much mor
Background Pancreatic ductal adenocarcinoma (PDAC) represents a major clinical challenge due to its tumor microenvironment, which exhibits immune-suppressive properties that facilitate cancer progression, metastasis, and therapy resistance. Interleukin 1 (IL-1) signaling has been implicated as a driver in this process. Mechanistically, both IL-1α and IL-1β bind to the IL-1 receptor type 1, forming
Background: Individualized cancer rehabilitation should be an integral part of cancer care. Contact nurses play a key role in identifying patient needs and coordinating evidence-based interventions to support rehabilitation. However, cancer rehabilitation remains marginal in current practice, as contact nurses face challenges due to the lack of systematic processes for assessment, intervention, an
A novel photodynamic therapy system based on interstitial illumination using multiple fibres is under development. The aim with this system is to enable treatment of large tumour volumes and also to utilise real-time measurements to allow on-line dosimetry. Important dosimetric parameters to measure are light fluence rate, sensitizer fluorescence intensity and local blood oxygenation. A constructi
Zone folded coherent acoustic phonons were generated in a multilayered GaSb/InAs epitaxial heterostructure via rapid heating by femtosecond laser pulses. These phonons were probed by means of ultrafast x-ray diffraction. Phonons both from the fundamental acoustic branch and the first back-folded branch were detected. This represents the first clear evidence for phonon branch folding based directly
During δ-aminolevulinic acid (ALA) based Interstitial Photodynamic Therapy (IPDT) a high light fluence rate is present close to the source fibers. This might induce an unintentional tissue temperature increase of importance for the treatment outcome. In a previous study, we have observed, that the absorption in the tissue increases during the treatment. A system to measure the local tissue tempera
In this work a compact fluorosensor has been built for point-monitoring and imaging applications. The instrument has been applied in fluorescence studies on green vegetation and on malignant tissue. The instrument is based on a violet diode laser, an integrated spectrometer and optical fibers for light delivery and collection of the fluorescence signal. This combination makes the system very compa
Popular Abstract in Swedish Akut faryngotonsillit orsakas till ca 40 % av betahaemolytiska grupp A streptokocker (GAS) och till ca 10% av andra bakterier. Ca 30% av fallen är virusutlösta och i ca 20% är genesen okänd. GAS är mycket virulenta humanpatogener som förutom svalg- och hudinfektioner även kan förorsaka livshotande tillstånd som ?streptococcal toxic shock syndrome? och nekrotiserande fasIn acute pharyngotonsillitis group A streptococci (GAS) is the etiological agent in 30-50% of cases. Phenoxymethylpenicillin (pcV) is the drug of choice in Sweden. However, the failure rate is as high as 5-25% and further pcV treatment is followed by still higher failure rates. The background of failures remains largely elusive. The aim of the studies was: 1 To investigate the short- and long-term
Popular Abstract in Swedish ”Att leva med cancer som äldre, livskvalitet och upplevelse av mening” Cancer drabbar företrädesvis äldre personer och är en sjukdom som blir vanligare i takt med det stigande antalet äldre i befolkningen. Cancer hos äldre innebär en komplex situation eftersom åldrandet är präglat av stora individuella förändringar med ökande sjuklighet, nedsatt funktionell förmåga, föThe overall aim of this thesis was to investigate quality of life in people aged 75 and older with cancer in relation to age, gender, presence and type of complaints, comorbidity, living conditions, perceived economic situation, sense of coherence, receiving help for daily living and social resources. The aim was also to investigate older people’s experiences and the meaning of living with cancer
In 2000 the European Council agreed on the so called ‘Lisbon Strategy’, the purpose of which is to make the European Union the strongest and most competitive economy in the world and also to fight unemployment and secure social welfare systems. One year later, in 2001, an ‘environmental dimension’ was supplemented to the Lisbon Strategy at the Council meeting in Gothenburg. An ‘EU Strategy for Sus
Popular Abstract in Swedish Idag finns det flera studier där livstillfredsställelse bland äldre har undersökts. Studierna är dels genomförda i varierande kontext och dels innehåller de varierande faktorer som hälsa, funktionell förmåga, självkänsla, sociala kontakter och finansiell situation. Därmed är det inte självklart att det finns gemensamma eller specifika faktorer, vilka är förknippade med The aim of this thesis was to investigate how older people's capacity to perform activities of daily living (ADL), health, social and financial resources, and self-esteem can be related to their life satisfaction. The aim was also to investigate how people feel hindered by health problems in relation to their ADL capacity, health problems, social and financial resources, self-esteem, sense of cohe
We have developed high-throughput tests for the detection of the insulin gene region SNPs -23HphI and -2221MspI. The potential of these markers to enhance the efficiency of type I diabetes risk screening was then evaluated by analyzing them in Finnish and Swedish populations. Blood spots on filter paper were analyzed using PCR followed by sequence- specific hybridization and time-resolved fluorome
