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Parkinson's disease (PD) is a neurodegenerative disease with unknown etiology. Here we show the generation of an induced pluripotent stem cell (iPSC) line, named CSC-40, from dermal fibroblasts obtained from a 59-year-old male patient with a homozygous p.Q456X mutation in the PTEN-induced putative kinase 1 (PINK/PARK6) gene and a confirmed diagnosis of PD, which could be used to model familial PD.
OBJECTIVES: To evaluate knowledge translation after publication of the target temperature management 33°C versus 36°C after out-of-hospital cardiac arrest trial and associated patient outcomes. Our primary hypothesis was that target temperature management at 36°C was rapidly adopted in Australian and New Zealand ICUs. Secondary hypotheses were that temporal reductions in mortality would be seen an
Under 2012–2014 organiserade VIWAFU, ett nätverk för internationellt och interdisciplinärt forskarsamarbete i Norden och Baltikum, fyra seminarier för master-studenter, doktorander och post-docs. Var och ett av seminarierna hade ett tema, t.ex. VA-branschens reglering och styrning, infrastruktur för dricksvatten, innovativ utveckling inom kommunala vattenfrågor samt vattenhantering Viable Water Management and Governance for Futures (VIWAFU), a professional network for international and interdisciplinary collaboration amongst researchers from the Nordic and Baltic countries, was built for providing and sharing knowledge on water management and governance for future policy and decision making during the years 2012–2014. VIWAFU organized four workshops for MSc stud
Popular Abstract in Swedish Sandstäpp är ett starkt hotat växtsamhälle i Sverige som består av många specialiserade och hotade arter som t.ex. sandnejlika, tofsäxing och sandliljor. Exempel på hur en sandstäpp kan se ut hittas i Figur 1 i den Engelska sammanfattningen. Sandstäpp finns på sandig mark med kalk i ytjorden och ett lågt näringsinnehåll. Den karaktäriseras av ett uppbrutet växttäcke somA number of sandy grassland habitats of interest for biodiversity conservation can be found in Europe. One such habitat is the threatened xeric sand calcareous grassland, which is home to a large number of endangered species. It is characterized by a discontinuous vegetation cover, mainly consisting of stress-tolerant species favoured by nutrient-poor and dry conditions. The xeric sand calcareous
Popular Abstract in Swedish Vad arbetar en analytisk kemist med? Exempel på kemiska analyser är att en idrottsman ska dopingtestas eller att eventuella föroreningar i vattnet från en bäck ska bestämmas. Den analytiska kemistens problemställning är vanligtvis att identifiera (kvalitativ analys) och mäta upp (kvantitativ analys) innehållet i ett prov. Ofta är de intressanta ämneshalterna mycket lågaCapillary electrophoresis is characterised by high separation efficiency, applicability to a wide range of compounds, small sample and solvent consumption and simple instrumentation. To improve sensitivity using on-line absorbance detectors, which are hampered by the short optical path length, sample volumes in the microlitre range were concentrated to nanolitre volumes either off-line or on-line.
Delamination plays a pivotal role during normal development and cancer. Previous work has demonstrated that delamination and epithelial cell movement within the plane of an epithelium are associated with a change in cellular phenotype. However, how this positional change is linked to differentiation remains unknown. Using the developing mouse pancreas as a model system, we show that β cell delamin
Most state-of-the-art natural gas-fired combined cycle (NGCC) plants are triple-pressure reheat cycles with efficiencies close to 60%. However, with carbon capture and storage, the efficiency will be penalized by almost 10% units. To limit the energy consumption for a carbon capture NGCC plant, exhaust gas recirculation (EGR) is necessary. Utilizing EGR increases the CO2 content in the gas turbine
The association between contextual factors and health inequalities is well documented, also in Brazil. However, questions about how contextual factors actually affect health and well-being persist. The aim of this qualitative study was to explore how contextual factors-i.e., social stratification and neighborhood opportunity structures-are manifested in the lives of the residents of a vulnerable d
Popular Abstract in Swedish En välfungerande andning med utbyte av syrgas och koldioxid mellan kroppen och omgivningen är en förutsättning för liv. För att detta gasutbyte ska fungera krävs bl. a. att ventilationen, dvs. in- och utflödet av luft i lungorna, står i balans med blodflödet genom lungorna. I lungorna tar blodet emot syrgas som behövs för att cellerna i kroppen ska fungera och samtidigtRespiration relies, among other things, on the balance between regional ventilation and perfusion in the lungs. There are many cardiopulmonary diseases, such as pulmonary embolism (PE), chronic obstructive pulmonary disease (COPD) and left heart failure (LHF), which can affect respiration negatively. The diagnosis of PE, COPD and LHF follows separate diagnostic pathways. However, the symptoms that
The extent to which in-situ global mechanical tensioning (GMT) can be used to modify the residual stress state in friction stir (FS) welds is investigated in this article. Residual stress distributions have been determined by synchrotron X-ray and neutron diffraction for four sets of FS welds in high-strength AA7449-W51 and lithium containing AA2199-T8 aerospace aluminum alloys subjected to a syst
Ten per cent of patients with colorectal cancer will develop peritoneal metastases. These metastases are known to have a lesser response to systemic chemotherapy than liver- and lung metastases. Randomized studies have shown that adding cytoreductive surgery and heated intraperitoneal chemotherapy (HIPEC) to this treatment gives a better chance of survival. Recently, a randomized study failed to s
Poland and polish courts have been the subject of much attention during recent years, because of alleged problems in relation to the organisation of justice in Poland. It has been claimed that new suggested legislation in Poland, and changes in the system for appointing judges, prevents courts in Poland from adjudicating justice in a fair and independent manner in accordance with the Rule of Law.
Background: Treatment of common bile duct (CBD) stones after Roux-en-Y gastric bypass (RYGB) poses a particular challenge given the altered anatomy and inability to perform a standard endoscopic retrograde cholangiogram (ERC). The optimal treatment strategy for intraoperatively encountered CBD stones in post-RYGB patients has not been established. Objectives: To compare outcomes following laparosc
This article suggests a model for lexical verb semantics that unifies Halliday’s model for transitivity with Langacker’s concept of base and profile and also with a model for situation type (cf. Smith 1997). It is claimed that verbs adhere to one of four macro domains: the material, the social, the mental or the relational domain. Within these domains there are numerous types of verbs, such as mot
Background Exertional breathlessness is a key symptom in cardiorespiratory disease and can be quantified using incremental exercise testing, but its prognostic significance is unknown. We evaluated the ability of abnormally high breathlessness intensity during incremental cycle exercise testing to predict all-cause, respiratory, and cardiac mortality. Study design and methods Longitudinal cohort s
China's technological growth in recent years has been explosive. Nowadays, Beijing based much of its socio-economic growth on improved technological performance in many areas. What are the main reasons that have enabled China to become a real IT giant? What are the geo-strategic implications of such growth in technology? To what extent can Chinese technical engineering improvements influence the c
