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Aims Oral anticoagulation with vitamin K antagonists (VKAs) for stroke prevention in atrial fibrillation (AF) is effective but has significant limitations. AZD0837, a new oral anticoagulant, is a prodrug converted to a selective and reversible direct thrombin inhibitor (AR-H067637). We report from a Phase II randomized, dose-guiding study (NCT00684307) to assess safety, tolerability, pharmacokinet

Based on data searches and life-table analyses, we determined the long-term (remaining lifetime) and short-term (10- and 5-year) absolute risks of hip fracture after sustaining a Colles' or spine fracture and searched for potential gender-related differences. In aging men, Colles' fractures carry a higher absolute risk for hip fracture than spinal fractures in contrast to women. These findings sup

Problemområde: Situationen på take-awaymarknaden i Sverige i relation till de möjligheter som finns för att utveckla denna i framtiden. För uppsatsen tas en utgångspunkt i följande generella frågeställningar: 1. Vilka teoretiska utgångspunkter finns för fenomenet? 2. Hur har fenomenet utvecklats och hur tar det sig uttryck idag? 3. Varför och hur arbetar företag med fenomenet? 4. Varför och hur ef

By employing seven semi-structured interviews with local judges and prosecutors in Kosovo, this study aims at examining how the European Union Rule of Law Mission (EULEX) has impacted the legal order in Kosovo and the practice of the judges and prosecutors. In addition, this study examines how the impacts of EULEX, and how the judges and prosecutors will be affected after the EULEX are withdrawn f

Medieevent har möjligheten att föra samman människor, men kan även leda till symboliska kamper mellan olika sociala grupper. Eurovision Song Contest är ett sådant event, där intresset för den europeiska sångtävlingen i sociala medier som Instagram är stort. Eftersom populärkultur och politik är svårt att särskilja i medieinnehåll som marknadsföring, och att fans dessutom kan engagera sig politiskt

A high interest in enterprise resource planning (ERPs) systems exists among small and medium sized enterprises (SMEs). This interest has created new ways of development of ERPs, such as open source ERP development. However, it is unclear what impact this has on diffusion of ERPs. To explore if open source ERP development impact diffusion of ERPs among SMEs a comparative investigation on proprietar

Milleniemål två och delvis tre har haft som ändamål att alla barn ska få gå i skolan och att skolan ska vara en jämställd plats år 2015. Dessa mål är fortfarande inte uppnådda och framför allt flickor drabbas av detta utfall. Syftet med denna uppsats är således att utvärdera UNESCOs egen tolkning av resultaten av deras projekt Education For All. Detta kommer att uppnås genom en granskning av rappo

Vascular risk factors are believed to be involved in dementia development by increasing risk of the most common dementia types, Alzheimer’s disease (AD) and vascular dementia. The aim of this thesis was to study if risk factors affect key brain pathology directly, by using biomarkers for dementia in preclinical stages, and to assess previous findings in a large population-based setting.Paper I: ar

The aim of the present study is to develop a mathematical model for evaluating therapeutic response of combined treatment modalities. The study was performed in rats of the Fischer-344 strain with rat glioma N32 or N29 tumors implanted subcutaneously on the thigh of the hind leg. Pulsed electric fields, PEF, with 16 exponentially decaying pulses with a maximum electric field strength of 140 V/mm a

Stem cell lines that faithfully maintain the regional identity and developmental potency of progenitors in the human brain would create new opportunities in developmental neurobiology and provide a resource for generating specialized human neurons. However, to date, neural progenitor cultures derived from the human brain have either been short-lived or exhibit restricted, predominantly glial, diff

BACKGROUND: Opioids are still widely prescribed to long-term pain patients although they are no longer recommended for long-term treatments due to poor evidence for long-term efficacy, risks of serious side effects, and the possibility of inducing opioid hyperalgesia. In a Cochrane study from 2017, the authors identified an urgent need for more randomized controlled trials investigating the effici

Heparan sulfate proteoglycans consist of a small family of proteins decorated with one or more covalently attached heparan sulfate glycosaminoglycan chains. These chains have intricate structural patterns based on the position of sulfate groups and uronic acid epimers, which dictate their ability to engage a large repertoire of heparan sulfate-binding proteins, including extracellular matrix prote

Purpose: Biokinetic and dosimetry studies in laboratory animals often precede clinical radionuclide therapies in humans. A reliable evaluation of therapeutic efficacy is essential and should be based on accurate dosimetry data from a realistic dosimetry model. The aim of this study was to develop an anatomically realistic dosimetry model for Brown Norway rats to calculate S factors for use in eva

Introduction TCP-25 gel is intended for use in treatment of wound infection and inflammation. Current local therapies for wounds have limited efficacy to prevent infections and there are no wound treatments available today that target the excessive inflammation that often hampers wound healing in both acute and chronic wounds. There is therefore a high medical need for new therapeutic alternatives

In recent years, the combination of the digitization of the field of pathology and increased computational power has led to a big increase in research of computer-aided diagnostics using systems based on artificial intelligence (AI). This includes detection and classification of prostate cancer, where several studies have shown great promise in automated prostate cancer grading using deep learning

BACKGROUND: Tuberculosis remains a leading infectious cause of death in resource-limited settings. Effective treatment is the cornerstone of tuberculosis control, reducing mortality, recurrence and transmission. Supporting treatment adherence through facility-based observations of medication taking can be costly to providers and patients. Digital adherence technologies (DATs) may facilitate treatm

PurposeThe paper aims to clarify how an incumbent retail organisation explores digitalisation for its existing business.Design/methodology/approachThe paper draws from an in-depth case study of home-furnishing retail giant, IKEA conducted with semi-structured interviews, participant observations and document analyses.FindingsIn the exploration phase of digitalisation, three major activities – inte