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AIM: It is of interest to predict possible lifetime risk of type 1 diabetes (T1D) in young children for recruiting high-risk subjects into longitudinal studies of effective prevention strategies.METHODS: Utilizing a case-control study in Sweden, we applied a recently developed next generation targeted sequencing technology to genotype class II genes and applied an object-oriented regression to bui
Objectives: The symptoms of Posttraumatic Stress Disorder (PTSD) and chronic pain are thought to interact to increase the severity and impact of both conditions, but the mechanisms by which they interact remain unclear. This study examines the relationship between PTSD and chronic pain and whether indices of psychological flexibility mediate the relationship between these two conditions.Methods: S
An extracellular matrix preparation, the human amnion membrane matrix (hAMM) can serve as a neurite-promoting substratum for cultured peripheral and central neurons, and also as a support for axonal growth in experimentally injured adult brain in vivo. In the present study, we tested similar materials as bridges in a silicone chamber model for the regeneration of sciatic nerve in the adult rat. Si
BACKGROUND: Breastfeeding initiation rates in some developed countries are high (98 % in Sweden and 96 % in Australia) whereas in others, they are not as favourable (46 % to 55 % in Ireland). Although the World Health Organization recommends exclusively breastfeeding for six months, 15 % of Australian women, 11 % of Swedish women and less than 7 % of Irish women achieve this goal. Awareness of wha
BACKGROUND: The standardized test used for evaluating the effect of warfarin is the prothrombin time (PT) which is measured and expressed in international normalized ratio (INR). Regular control of treatment intensity is required since inappropriate dosage increases the risk for complications. Portable point-of-care analytical instruments for measurement of capillary whole blood PT have been avail
Scand J Caring Sci; 2011 Individual placement and support - a model to get employed for people with mental illness - the first Swedish report of outcomes Lack of participation in the open labour market is highly prevalent for people with a mental illness across countries, and the proportion of people who get some kind of sickness benefit because of mental illness is steadily growing in Europe. Voc
We propose a method for dividing large regions into biogeographical sub-regions based mainly on natural disturbance regime, forest history and potential tree species distribution. This subdivision could be used as a guide when designing conservational strategies and management plans for landscapes and protected areas. At present, conservational strategies and management of valuable areas on the on
OBJECTIVE: Pulse pressure (PP) is a risk marker for cardiovascular disease (CVD) in individuals 50 years and older. Inflammation is suggested to influence atherosclerosis, but could also increase PP. We aimed to examine the combined effects of PP and the inflammatory marker sialic acid, and their independent roles on CVD risk. METHODS: From a population-based study in Sweden between 1962 and 196
Human embryonic stem cells (hESCs) are a potential source of dopaminergic neurons for treatment of patients with Parkinson's disease (PD). Dopaminergic neurons can be derived from hESCs and display a characteristic midbrain phenotype. Once transplanted, they can induce partial behavioral recovery in animal models of PD. However, the potential research field faces several challenges that need to be
OBJECTIVES: /st> To investigate the association between meniscal pathology and incident or enlarging bone marrow lesions (BML) in knee osteoarthritis. METHODS: /st> The authors studied subjects from the Multicenter Osteoarthritis Study aged 50-79 years either with knee osteoarthritis or at high risk of the disease. Baseline and 30-months magnetic resonance images of knees (n=1344) were scored for
The objective of this investigation was to explore a hybrid application of Structural Equation Modelling (SEM) and Fuzzy-set Qualitative Comparative Analysis (FsQCA) to assess the impact of safety-related behavioural traits on the performance of bicyclists using a limited sample of data as a case study. These behavioural characteristics of cyclists are fundamental when specific cyclist groups are
We investigate the impact of employment protection regulation on firms’ reluctance to apply for bank finance (loans and overdrafts). Our findings reveal that longer notice periods reduce the likelihood that firms are discouraged from applying for bank finance in the case of blue-collar workers, but they increase it in the case of white-collar workers. Our interpretation is that, in the case of blu
Background: After an older person moves into a nursing home, the next of kin often continues to participate in the care provided there. This participation in care may contribute valuable knowledge of the preferences and wishes of the older person, thereby helping nursing staff deliver personalised care. Objectives: The aim of this study was to explore how next of kin experience their participati
Biocompatibility studies, especially innate immunity induction, in vitro and in vivo cytotoxicity, and fibrosis, are often lacking for many novel biomaterials including recombinant protein-based ones, such as elastin-like recombinamers (ELRs), and has not been extensively explored in the scientific literature, in contrast to traditional biomaterials. Herein, we present the results from a set of ex
Aims T cells are present in atrial tissue from atrial fibrillation (AF) patients. However, prospective studies of T cells and AF development are few. The current aim was to investigate if T-cell subsets are associated with the risk of developing AF. Methods and results T-cell subsets, measured by flow cytometry of cryopreserved mononuclear leucocytes isolated from blood at baseline, were analysed
Mango production plays a vital role in rural livelihoods in Mozambique, yet post-harvest losses remain high, ranging from 25% to over 50%, due to inadequate preservation methods. Improved solar drying technologies offer a sustainable solution by extending shelf life and enhancing product quality. However, their adoption among smallholder mango farmers remains limited. This study investigates the k
Obesity is a known risk factor for poor breast cancer outcomes, but its impact on endocrine therapy efficacy remains unclear. While the ATAC trial suggests reduced effectiveness of aromatase inhibitors (AIs) in women with obesity, the BIG 1–98 trial found no significant differences. Clinical and biological evidence indicates that obesity may impair AI efficacy by increasing aromatase activity and
Climate change and its associated extreme events challenge the effectiveness of passive building design strategies. Hybrid passive-active systems emerge as a promising solution; however, their resilience in extreme climate conditions is less studied. This study addresses this gap by investigating the integration of solar chimneys (SC) with variable refrigerant flow (VRF) systems to improve thermal
