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High-sensitivity troponin T is an important independent predictor in addition to the Simplified Acute Physiology Score for short-term ICU mortality, particularly in patients with sepsis

Purpose: Elevated cardiac troponin levels have been shown to be associated with a poor prognosis under some intensive care conditions. This study investigated whether inclusion of high-sensitivity troponin T (hsTnT) increased the prognostic accuracy of the Simplified Acute Physiology Score (SAPS 3) for general intensive care unit (ICU) patients, cardiac arrest patients, or patients with a non-card

Acidosis enhances translocation of protein kinase C but not Ca2+/calmodulin-dependent protein kinase II to cell membranes during complete cerebral ischemia

Systemic hyperglycemia and hypercapnia severely aggravate ischemic brain damage when instituted prior to cerebral ischemia. An aberrant cell signaling following ischemia has been proposed to be involved in ischemic cell death, affecting protein kinase C (PKC) and the calcium calmodulin kinase II (CaMKII). Using a cardiac arrest model of global brain ischemia of 10 min duration, we investigated the

Models for studying long‐term recovery following forebrain ischemia in the rat. 2. A 2‐vessel occlusion model

ABSTRACT— A model is described in which transient ischemia is induced in rats anaesthetized with N2O:O2 (70:30) by bilateral carotid artery clamping combined with a lowering of mean arterial blood pressure to 50 mm Hg, the latter being achieved by bleeding, or by bleeding supplemented with administration of trimetaphan or phentolamine. By the use of intubation, muscle paralysis with suxamethonium

Cortical spreading depression is associated with arachidonic acid accumulation and preservation of energy charge

The present study aimed to study the relation between the release of arachidonic acid (AA) and the energy state in cerebral cortices of rats during single episodes of cortical spreading depression (CSD). The changes in concentrations of AA, labile phosphate compounds [ATP, ADP, AMP, and phosphocreatine (PCr)], and glycolytic metabolites (lactate, pyruvate, glucose, and glycogen) were studied durin

Climate change and transboundary water management in the Tunisian Mellegue Catchment

Human activities and climate change affect hydrological and sedimentological characteristics within catchments. For arid and semiarid areas this induces direct negative economic and environmental consequences on society. In fact, stability in the rainfall regime and less siltation trapped in reservoirs mean more water for irrigation, water supply, and better flood control. This is especially impor

Interdisciplinary Water Research Network Building within Nordic and Baltic Countries

Under 2012–2014 organiserade VIWAFU, ett nätverk för internationellt och interdisciplinärt forskarsamarbete i Norden och Baltikum, fyra seminarier för master-studenter, doktorander och post-docs. Var och ett av seminarierna hade ett tema, t.ex. VA-branschens reglering och styrning, infrastruktur för dricksvatten, innovativ utveckling inom kommunala vattenfrågor samt vattenhantering i turistområdenViable Water Management and Governance for Futures (VIWAFU), a professional network for international and interdisciplinary collaboration amongst researchers from the Nordic and Baltic countries, was built for providing and sharing knowledge on water management and governance for future policy and decision making during the years 2012–2014. VIWAFU organized four workshops for MSc students, PhD stu

Inhibitory effect of barusiban and atosiban on oxytocin-induced contractions of myometrium from preterm and term pregnant women

BACKGROUND: A synthetic oxytocin analogue, barusiban, was shown to potently inhibit oxytocin-induced activity of myometrium from term pregnant women. The responsiveness to vasopressin was not influenced by the compound. OBJECTIVE: To test the effect of barusiban and a reference compound, atosiban, on oxytocin-induced activity of myometrium from women at preterm pregnancy in comparison to myometriu

Riktlinjer-om-fordelning-av-beslutsbefogenheter-och-ratt-att-teckna-avtal-vid-LU

Riktlinjer om fördelning av bealutsbefogenheter och rätt att teckna avtal vid Lunds universitet FÖRSÄTTSSIDA STYRDOKUMENT Riktlinjer om fördelning av beslutsbefogenheter och rätt att teckna avtal vid Lunds universitet Typ av styrdokument: Riktlinjer Definition av typen av styrdokument: Riktlinjer fastställer hur någon ska eller bör handla inom det område riktlinjerna omfattar. En ska- regel ska fö

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2026-03/riktlinjer-om-fordelning-av-beslutsbefogenheter-och-ratt-att-teckna-avtal-vid-LU.pdf - 2026-06-08

Learning from the past to plan for the future : A scoping review of musculoskeletal clinical research in Sweden 2010-2020

Background: The aims of this study are to 1) determine the scope of musculoskeletal (MSK)-related clinical research in Sweden; 2) collate the amount of first-tier funding received; 3) discuss strategies and infrastructure supporting future MSK clinical trials in Sweden. Methods: A systematic scoping review protocol was applied in PubMed, Scopus, and SweCRIS databases. The articles were examined, a

Iterative importance sampling with Markov chain Monte Carlo sampling in robust Bayesian analysis

Bayesian inference under a set of priors, called robust Bayesian analysis, allows for estimation of parameters within a model and quantification of epistemic uncertainty in quantities of interest by bounded (or imprecise) probability. Iterative importance sampling can be used to estimate bounds on the quantity of interest by optimizing over the set of priors. A method for iterative importance samp

Abnormally high exertional breathlessness predicts mortality in people referred for incremental cycle exercise testing

Background Exertional breathlessness is a key symptom in cardiorespiratory disease and can be quantified using incremental exercise testing, but its prognostic significance is unknown. We evaluated the ability of abnormally high breathlessness intensity during incremental cycle exercise testing to predict all-cause, respiratory, and cardiac mortality. Study design and methods Longitudinal cohort s