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IgG glycan hydrolysis by EndoS diminishes the pro-inflammatory properties of immune complexes from patients with SLE - a possible new treatment?

OBJECTIVE.: Systemic lupus erythematosus (SLE) is an autoimmune disease with chronic or episodic inflammation in several organ systems, related to the presence of circulating and tissue-deposited immune complexes (ICs) which stimulate leukocytes through FcγRs with subsequent inflammation. Treatment with EndoS, an IgG glycan hydrolyzing bacterial enzyme from Streptococcus pyogenes, has shown benefi

Den pedagogiska praktikens janusansikte: om det kommunikativa handlandets didaktiska villkor och konsekvenser

Popular Abstract in Swedish Villkoren för utbildning och undervisning förändras i väsentliga avseenden i takt med samhällets tilltagande komplexitet. Det är många gånger svårt för både lärare och elever att veta hur man på bästa sätt ska orientera sitt pedagogiska handlande. Med utgångspunkt från tre pedagogiska kontexter - grundskolan, de särskilda ungdomshemmen och grundskollärarutbildningen - pPedagogical practice is, in several important considerations, contradictory in character. In this dissertation attenention is drawn towards the field of tension that prevails between pedagogical action, which can be descibed in terms of strategic processes and communicative pedagogical action. While the former places the preconditions for effective knowledge development of the individual at the ce

Power system damping in Iceland based on phasor measurements

Phasor measurement signals are used as only input to a wide-area power system stabilizer to increase interarea mode damping of the Icelandic system. Modal analysis and time simulations of a detailed model show that frequency difference as PSS input gives a damping improvement that is robust to drastic changes in system topology. Field data from phasor measurement units indicate high signal quality

Elizabeth Bennet vs Katniss Everdeen

Analys av hjältinnan utifrån ett feministiskt perspektiv. En jämförelse mellan Jane Austens hjältinna Elizabeth Bennet i Pride and Prejudice och Suzanne Collins hjältinna Katniss Everdeen i The Hunger Games.Analysis of the heroine from a feminist perspective. A comparison between Jane Austen's heroine Eliabeth Bennet in Pride and Prejudice and Suzanne Collins' heroine Katniss Everdeen in The Hunger Games.

En stödd kultur, en stött kultur : Litteraturstödet 2018 - föreställningar och förväntningar

I början av 2018 utbröt en debatt om kulturrådets utdelning av litteraturstöd i svenska dagstidningar. I samband med uttalanden från kulturminister Alice Bah Kuhnke menade vissa av bokmarknadens aktörer att litteraturstödet är utsatt för politisk styrning och att kvalitetskriteriet bortprioriteras. Uppsatsen undersöker de olika förväntningarna och föreställningarna som finns på litteraturstödet. J

Fundamental review of the trading book - The new approach to measure market risk

The Fundamental Review of the Trading Book sets the standard for the most recent regulatory framework for minimum capital requirement within market risk. It will be implemented gradually up until 2019 and will overhaul a major part of the current regulation. More specifically it will cause financial institutions to estimate risk with Expected Shortfall instead of Value-at-Risk and add a new way of

Åka hem? – Den individuella utlänningskontrollen och rörlighetsdirektivets genomförande i svensk rätt

I folkrättsligt hänseende är en stat endast skyldig att låta de egna medborgarna uppehålla sig på dess territorium. Ur ett EU-rättsligt perspektiv är dock varje medlemsstat förpliktad att tillämpa de regler som avser främja fri rörlighet för personer inom unionen. Dessa återfinns i EU:s primärrättsliga stadganden men konkretiseras genom sekundärrättsliga bestämmelser, framförallt genom direktiv 20With regard to international law, a state is only required to allow its citizens to reside within its own territory. However, from an EU law perspective, each Member State is obliged to apply regulations which intend to facilitate the free movement of persons within the EU. This is expressly laid down in the EU treaties, but must be viewed within the context of secondary law, in particular, the Ci

Effect of pore size on the gasification of biomass char

The evolution of char porous structure can affect the gasification rate of biomass char. A model based on the classical capillary pores is developed taking into account different conversion rates for pores having different radii. The contribution of different pores with different radii is taken into account using an effectiveness factor presented for each pore radius. As the char conversion procee

Between Self-Determination, Consistency and Rights Protection: Process-Based Review in Expulsion Cases under Article 8 of the European Convention on Human Rights

Den här uppsatsen undersöker Europadomstolens praxis gällande utvisningar av personer som har begått brott, som hävdar att deras utvisning strider mot Artikel 8 av Europakonventionen. Uppsatsen undersöker hur domstolen har använt sig av den nationella beslutsprocessens kvalitet som ett argument för att komma fram till sin slutsats i sådana fall. Uppsatsen utgår från premissen att utvisningar som bThis thesis examines the practice of the European Court of Human Rights to decide expulsion cases implicating migrants with criminal record under Article 8 of the European Convention on Human Rights by use of process-based review. It departs from the premise that such expulsions do not violate absolute rights but constitute interferences with a qualified right, which allows for infringements neces

Kampen för rättigheterna - Mänskliga fri- och rättigheter i svensk rättskultur. Historik samt den rättsvetenskapliga diskursen 1940-2010

Are there such things as moral, rights and an inner sense of justice? Do they origin from God or are they something given by nature? If there are such things, should they be a part of the legal system? This essay has drawn its inspiration from this kind of thoughts and how they have been handled through history. The structure of the essay is two-folded. Part one is a historical review of the eme

Forskningen möter fältet : en kartläggning av branschtidskrifternas forskningsbevakning 1994-2002

Library and information science (LIS), is a research area marked by theoretical diversity and strong influence from both the developing library profession, as well as other social sciences. During the development of LIS several attempts have been made to define its scientific identity. The definition of what constitutes core, boundaries and the superior identity of LIS is still debated among resea

A comparison of the Basel III capital requirement models for financial institutions

The purpose of this report is to implement and compare the two Basel III standard methods on how to calculate the capital requirement for finan- cial institutions, related to counterparty credit risk. The models being the Standardized Approach for Counterparty Credit Risk (SA-CCR) and the Internal Model Method (IMM). The SA-CCR model is a simpler and more standardized model with prescribed methods