Filtyp
This master’s thesis explores the impact from the fire investigations by the Swedish Accident Investigation Authority (SHK) on fire safety in Sweden. Through a mapping survey and a qualitative interview study, it is found that it is often difficult to identify clear connections between the investigations’ safety recommendations and real improvements to fire safety, due to long time spans and multi
Denna berättelse om Synergi mellan Strål- och Immun-Terapi har sitt ursprung i resultaten av försök som utfördes år 2001 vilka avsåg att kombinera tumörvaccin-behandling med strålterapi av Fischer-344 råttor med gliom-tumörer inokulerade i hjärnan.Med 3 omgångar tumörvaccin kombinerat med endast en fraktion strålterapi á 5Gy, överlevde sex av åtta behandlade djur (ca.75%). Detta dramatiska resulta
Popular Abstract in Swedish Neuroblastom är den vanligaste solida tumören, utanför hjärnan, hos små barn och finns nästan inte alls hos vuxna. Varje år insjuknar mellan femton och tjugo barn i Sverige, de flesta före två års ålder. Överlevnaden har ökat de senaste tjugo åren men är fortfarande på låga nivåer för de mer aggressiva formerna. Neuroblastom uppstår i det sympatiska nervsystemet. DärförIn this thesis, the main focus has been on the childhood cancer neuroblastoma, one of the most common and lethal childhood tumours. Neuroblastoma has througout the years continued to be a clinical and biological enigma. Our first focus was on one of the most important biological risk factors in neuroblastoma -- amplification of the oncogene MYCN in the tumour cells. Because amplified MYCN typical
The temperature distribution in concrete structures varies due to annual and daily climate variations. Solar radiation, air temperature, wind speed and long-wave radiation affect the temperature in the structure and may cause longitudinal and transversal movements. If these movements are restrained, stresses and strains can be induced which may contribute to cracking. To be able to predict the lon
Popular Abstract in Swedish Tre-dimensionell ultraljudsundersökning av livmodertappen (cervix) Syftet med avhandlingen var att utvärdera förändringar i livmodertappen (cervix) med tre-dimensionellt ultraljud och utreda om tre-dimensionellt power Doppler ultraljud kan förutsäga tiden till spontan eller inducerad förlossning hos överburna, gravida kvinnor. Avhandlingen baseras på fem studier: reprThe aim of this thesis was to evaluate cervical physiological changes by three-dimensional (3D) ultrasound during pregnancy and to investigate the ability of 3D power Doppler to predict time to spontaneous and induced delivery in prolonged pregnancy. The thesis is based on five studies: reproducibility of cervical measurements by 3D power Doppler ultrasound (study I), reference data representativ
Popular Abstract in Swedish Prostatacancer är en mycket vanlig form av cancer, och det har visats att cirka hälften av alla män över 70 år har tumör i prostata. Prostatacancer är ofta en latent form av cancer, vilket innebär att den sällan ger kliniska symtom förrän i ett framskridet stadium. Sedan PSA testet började användas på 90-talet har antalet diagnostiserade fall av prostatacancer blivit alProstate cancer is currently the most common form of cancer in Sweden. Currently, the only biomarker used in the clinic is serum PSA, and there is a great need for new biomarkers that may increase the diagnostic and prognostic information so that better predictions can be made, and treatment may be tailored. Here, we have investigated two proposed biomarkers microseminoprotein-β (MSMB) and cystein
Mycket har skett i jordbruket det senaste århundradet. Vi har rört oss från ett småbondesamhälle till ett mekaniserat, industrialiserat och kapitaliserat jordbrukssamhälle med en global marknad. Denna intensifiering av jordbruket har lett till förlust och fragmentering av biotoper vilket givetvis har påverkat den biologiska mångfalden negativt. När arter minskar eller försvinner riskerar vi även aModern agricultural practices have led to an intensification of the agricultural landscape which has negatively affected both biodiversity and the ecosystem services it provides. In my thesis I have used ecological theory of optimal foraging to try and explain how landscape structure, landscape composition and agricultural management can explain the loss of biodiversity and how remedies can effici
The population of patients with moderate and severe CKD is growing. Frail and older patients comprise an increasing proportion. Many studies still exclude this group, so the evidence base is limited. In 2013 the advisory board of ERBP initiated, in collaboration with European Union of Geriatric Medicine Societies (EUGMS), the development of a guideline on the management of older patients with CKD
With improvements in cancer treatment and supportive care, a growing population of survivors of childhood cancer at risk for significant and potentially life-threatening late effects has been identified. To provide a current snapshot of the models of care from countries with varying levels of resources and health care systems, stakeholders in childhood cancer survivorship clinical care and researc
Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children RESEARCH ARTICLE Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children Ezio Bonifacio1, Andreas Beyerlein2,3,4, Markus Hippich2,3,4, Christiane Winkler2,3,4, Kendra Vehik5, Michael N. Weedon6, Mic
Background Studies on the survival of patients with home mechanical ventilation (HMV) are sparse. We aimed to analyse the impact of controlled hypercapnia on survival over 27 years among patients with HMV in Sweden. Study design and methods Population-based cohort study of adult patients starting HMV in the Swedish Registry for Respiratory Failure (Swedevox) during 1996–2022 cross-linked with the
Analyzes research and innovation in the European Union against the backdrop of the COVID pandemic, Brexit, global challenges and a changing international landscape.
Background: There is variation in the care provided to men with metastatic prostate cancer (mPCa). There has been no previous set of quality indicators (QIs) regarding the management of men with mPCa. The objective of this study is to develop a set of international mPCa-specific QIs, which will enable global benchmarking of quality of care. Materials and methods: Potential QIs were identified thro
Background: Integrated community case management (CCM) has led to reductions in child mortality in Malawi resulting from illnesses such as malaria, pneumonia, and diarrhea. However, adherence to CCM guidelines is often poor, potentially leading to inappropriate clinical decisions and poor outcomes. We determined the impact of an e-CCM app on the referral, reconsultation, and hospitalization rates
