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doi:10.1016/j.yexcr.2006.12.014 Research Article Ngn2 and Nurr1 act in synergy to induce midbrain dopaminergic neurons from expanded neural stem and progenitor cells Elin K.I. Anderssona,b, Dwain K. Irvina,c, Jessica Ahlsiöa, Malin Parmara,b,⁎ aWallenberg Neuroscience Center, Division of Neurobiology, Lund University, BMC A11, S-221 84 Lund, Sweden bLund Strategic Center for Stem Cell Biology and
Cell‐based therapy for Parkinson's disease: A journey through decades toward the light side of the Force Eur J Neurosci. 2018;1–9. | 1wileyonlinelibrary.com/journal/ejn 1 | INTRODUCTION It was with great sadness that we all received the news about Tom’s passing. He was a force for good in the Parkinson’s disease (PD) community and he will be greatly missed. For Tom, nothing was too serious
Jordbrukslandskapet tillhandahåller ekosystemtjänster som utgör förutsättningen för en uthållig jordbruksproduktion och är till nytta för samhället i stort. Bakom dessa finns ekologiska processer som beror av samspel mellan en mångfald av organismer. Skånes jordbruk har genomgått betydande förändringar som förändrat landskapet och livsmiljön för många av dessa. För att bevara och förvalta ekosyste
Popular Abstract in Swedish Mjölk anses som det enda flytande livsmedlet som på naturlig väg innehåller de tre fundamentala byggstenarna, fett, protein och kolhydrater, vilket definierar ett livsmedel näringsmässigt. Majoriteten av världens vuxna befolkning är dock tvungen att ha en begränsad konsumtion av mjölk då toleransen för dess kolhydrat, laktos, minskar med vuxen ålder. Detta beror främst This thesis deals with the fermentation characteristics of lactic acid bacteria (LAB) in oat-based suspensions, with formulation work of fermented products based on oat and with nutritional studies of these products. Changes in structure in terms of viscosity and ropiness were studied when exopolysaccharide (EPS)-producing LAB strains, namely, Lactobacillus delbrueckii subsp. bulgaricus NCFB 2772,
This paper sets out to investigate what effects healthcare privatisation has on healthcare staffing levels and other healthcare metrics in regional Swedish healthcare. Using econometric techniques and relying on public data of public healthcare spending on private actors as a proportion of total regional healthcare spending, this paper finds that privatisation in general has no significant effects
Biodiversity is fundamental for human well-being, and we depend on nature’s ecosystem services for our survival. Today, biodiversity loss occurs at an accelerating rate and the number of endangered species is higher than ever. Despite this, biodiversity loss has long been overshadowed by the climate issue. However, the issue of biodiversity is now receiving more attention and new frameworks and po
The 17th September 2001 the distributor Schenker started to cooperate with the computer systems manufacturer Dell to deliver Dell's products to the Nordic market. In the beginning of a new cooperation new processes are formed and they are often developed to solve the local, immediate problems without considering the overall picture. In the distribution network from Dell's plants in Ire
The aim of this double-blind, placebo-controlled, cross-over study was to investigate possible improvement in physical performance at an ambient temperature of -15 degrees C by an inhaled dose of 50 micrograms salmeterol in 8 highly trained nonasthmatic cross-country skiers. FEV1 was measured before, during and after the treadmill exercise protocol, which consisted of a warm-up run, runs of 10 min
Anterior cruciate ligament (ACL) injury is associated with mechanical instability and defective neuromuscular function, and can lead to further injury, increased joint loading and osteoarthritis. Patients with ACL injury demonstrate altered postural orientation, manifested as observable "substitution patterns" (SPs) but no one has applied a clinically useful method to systematically study postural
During lipolysis of chylomicron triacylglycerol by lipoprotein lipase, arachidonic acid (AA) esters are hydrolyzed at a slower rate than the predominant 16-18 carbon fatty acid esters. The further metabolism of the AA that is hereby enriched in the chylomicron remnant acylglycerols has not been investigated. In the present study, we examined the low density lipoprotein (LDL) dependent and independ
EU:s gemensamma jordbrukspolitik (CAP) är ett av de viktigaste styrmedlen för svenskt jordbruk, både när det gäller ekonomiska resurser och med avseende på hur stora arealer mark som påverkas. I den nuvarande CAP finns medel avsatta för miljöåtgärder såväl inom pelare 1 genom de så kallade förgröningsåtgärderna, som genom Landsbygdsprogrammet (pelare 2) via miljöstöden. Därmed skulle det kunna fin
PURPOSE: This study aimed to evaluate patient-reported outcomes as well as lower extremity and trunk muscle function in patients with long-standing hip and groin pain, in comparison with matched, healthy controls. It was hypothesized that patients with long-standing hip and groin pain would report more deficiency on the Copenhagen Hip and Groin Outcome Score (HAGOS) and have worse outcomes on perf
Membrane interactions are critical for the successful use of mesoporous silica nanoparticles as delivery systems for antimicrobial peptides (AMPs). In order to elucidate these, we here investigate effects of nanoparticle charge and porosity on AMP loading and release, as well as consequences of this for membrane interactions and antimicrobial effects. Anionic mesoporous silica particles were found
We aimed to estimate and compare within-day energy balance (WDEB) in athletes with eumenorrhea and menstrual dysfunction (MD) with similar 24-hour energy availability/energy balance (EA/EB). Furthermore, to investigate whether within-day energy deficiency is associated with resting metabolic rate (RMR), body-composition, S-cortisol, estradiol, T3 , and fasting blood glucose. We reanalyzed 7-day di
Objectives: Skeletal muscle performance is determined by muscle temperature. This paperpresents a review of the research literature to contribute to a better understanding of thephysiological mechanisms of muscle fatigue and performance in cold exposure and in repetitiveor sustained physical exertion in terms of isometric maximal force production,electromyographic activities, and gait ground react
When we communicate with others, we use a variety of abilities to facilitate and enable that communication. These abilities range from being responsive to others’ communicative cues to making one’s own communication more functional. Such facilitators of communication has been suggested as atypical in the development of autism. Reduced infant responsiveness towards communicative cues -– such as speWhen we communicate with others, we use a variety of abilities to facilitate and enable that communication. These abilities range from being responsive to others’ communicative cues to making one’s own communication more functional. Such facilitators of communication has been suggested as atypical in the development of autism. Reduced infant responsiveness towards communicative cues – such as spe
Wanting to help others and benefit society in one’s future career are examples of communal career goals. Raising these goals in youth should increase interest in HEED-occupations (Healthcare, Early Education, Domestic, and the Domestic fields) which are strongly gender-skewed and face labor shortage. Research has yet to find ways to increase communal career goals. In this study, we test the novel Wanting to help others and benefit society in one’s future career are examples of communal career goals. Raising these goals in youth should increaseinterest in HEED-occupations (Healthcare, Early Education, Domestic, and the Domestic fields) which are strongly gender-skewed and face labor shortage.Research has yet to find ways to increase communal career goals. In this study, we test the novel hy
Background: Breathlessness is a troublesome and prevalent symptom in the population, but knowledge of related factors is scarce. The aim of this study was to identify the factors most strongly associated with breathlessness in the general population and to describe the shapes of the associations between the main factors and breathlessness.Methods: a cross-sectional analysis of the multicentre popu
