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Overuse of antibiotics is accelerating the antimicrobial resistance among pathogenic microbes which is a growing public health challenge at the global level. Higher resistance causes severe infections, high complications, longer stays at hospitals and even increased mortality rates. Antimicrobial resistance (AMR) has a significant impact on national economies and their health systems, as it affect
We have previously described a new series of selective and orally available galectin-1 inhibitors resulting in the thiazole-containing glycomimetic GB1490. Here, we show that the introduction of polar substituents to the thiazole ring results in galectin-1-specific compounds with low nM affinities. X-ray structural analysis of a new ligand-galectin-1 complex shows changes in the binding mode and l
Frontotemporal dementia (FTD) is the second most common cause of early-onset dementia after Alzheimer disease (AD). Efforts in the field mainly focus on familial forms of disease (fFTDs), while studies of the genetic etiology of sporadic FTD (sFTD) have been less common. In the current work, we analyzed 4,685 sFTD cases and 15,308 controls looking for common genetic determinants for sFTD. We found
Citizens have increasingly diversified their use of social media platforms, raising questions about which platforms are adopted and for what purposes. We use survey data from four countries (Canada, France, the United States, and the United Kingdom) gathered in 2019 and 2021 (n = 12,302) about Facebook, YouTube, Instagram, Twitter, Reddit, Snapchat, and WhatsApp. Political ideology predicts the ad
Both trio and population designs are popular study designs for identifying risk genetic variants in genome-wide association studies (GWASs). The trio design, as a family-based design, is robust to confounding due to population structure, whereas the population design is often more powerful due to larger sample sizes. Here, we propose KnockoffHybrid, a knockoff-based statistical method for hybrid a
Presented is the search for anomalous Higgs boson decays into two axion-like particles (ALPs) using the full Run 2 data set of 140fb-1 of proton-proton collisions at a centre-of-mass energy of 13TeV recorded by the ATLAS experiment. The ALPs are assumed to decay into two photons, providing sensitivity to recently proposed models that could explain the (g-2)μ discrepancy. This analysis covers an AL
There have been reforms in the public sector, from the bureaucratic form of organization to the business community inspired reforms called New Public Management. These reforms have been seen as positive but also negative, especially against downplaying of democratic values. In connection with these changes, even the language being touched. The earlier one named citizen is now called customers. Thi
Simulating the natural environment of living tissue with in vitro cell culture models has paved the way for scientific discoveries, and provided valuable insight into areas such as drug discovery and regenerative medicine. A new emerging technique of culturing cells on biomimetic three-dimensional scaffolds stands as a promising alternative to the traditional way of culturing cells on two-dimensio
The primary purpose of this paper is to further build on research related to capability development in order to explore hindrances and benefits of internal capability development and external partnerships as ways to improve performance. The beverage industry is used as the focus context since the companies in this industry are increasingly responding to external trends and looking for ways to deve
With the 11th century text Kitāb ādāb al-nikāḥ, the “Book on the Proper Conduct of Marriage”, the Islamic thinker al-Ghazālī (1056 –1111/447–504) replies to a contemporaneous debate within Sufi asceticism with a theology of nikāḥ. The text is part of his opus magnum, the “Renaissance of the Knowledge of dīn”, which aims at a renewal of Muslim piety and provides practical guidance to the male audie
This conceptual thesis analyses Carlota Pérez vision of a ‘Green Global Golden Age’ that is supposed to reconcile the tension between economic growth and sustainability (Pérez, 2016b). Aiming to address the pressing issue of continued unsustainability, Pérez’ proposed solution is based on the assumption that technological innovation in the field of Information and Communication Technologies (ICT)
Anthropogenic climate change and environmental degradation demand humanity to depart from the growth imperative forming the economic structure of the world. In other words: Structural transformation is needed. Much of the sustainability debate in academy, politics, media and the public revolves around two paradigms: minor changes within the current system (e.g. green consumption, green growth) or
Block copolymer lithography is a very promising candidate for nanoscale fabrication and is economically viable. It provides a high resolution, inexpensive, and straightforward approach to nano-size patterning. In this thesis, fundamental concepts and theories of block copolymer lithography are introduced. A well-controlled dynamic solvent vapor annealing chamber is built, and the best annealing co
This study explores the opportunity of advancing climate focused projects within the Swedish energy and climate advising. Inspired by behavioural change and climate communication theory, a pilot project was developed where a climate advising service was tested and reviewed. Further, interviews with responsible climate and energy advisors of other climate focused projects were performed, and togeth
Rockfalls occur around Sweden every year and the country lacks a national risk evaluation and an adequate regulatory framework for construction related to this natural hazard. The aim of this study is to address this problem by mapping areas under possible threat of rockfalls, considering two fundamental aspects: i) identification of the source areas and ii) estimation of the runout zones. The stu
To this day, the question of what factors drive economic development and catching-up remains deeply controversial in growth literature. The concept of social capability provides a useful framework to investigate the relationship of the parallel processes of transformation, inclusion, autonomy and accountability with economic performance. Nevertheless, there are few attempts to quantify social capa
Freezing injuries usually take place in thawed plant-based food products. To reduce freezing injuries, Pulse Electric Field (PEF) treatment and Vacuum Impregnation (VI) of cryoprotectant were used before the freezing process. The aim of PEF is to provoke electroporation to the membranes of the plant cells, thereby allowing the cryoprotective solution impregnated by VI to penetrate the cells. PEF
This thesis is a case study which investigates political parties’ reasons and driving forces for advocating an expansion of E6 in Skåne with respect to the fact that the highway today has reached its full capacity. The two biggest parties in the region, the Social Democratic Party and the Moderate Party, have been included in the research. The arguments stated by each party, revealed through semi-
