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The Particle Finite Element Method (PFEM) is attractive for the simulation of large deformation problems, e.g. in free-surface fluid flows, fluid–structure interaction and in solid mechanics for geotechnical engineering and production processes. During cutting, forming or melting of metal, quasi-incompressible material behaviour is often considered. To circumvent the associated volumetric locking
Background: Osteonecrosis (ON) is a potentially disabling skeletal complication of cancer treatment. Although symptomatic osteonecrosis (sON) is well-known in acute lymphoblastic leukemia (ALL), with an incidence around 6%, studies on sON in pediatric Hodgkin lymphoma (HL) are scarce. The aim of this study was to examine the incidence, risk factors, and outcome of sON in children treated for HL. P
Accurate regulation of microfilament dynamics is central to cell growth, motility and response to environmental stimuli. Stabilizing and depolymerizing proteins control the steady-state levels of filamentous (F-) actin. Capping protein (CP) binds to free barbed ends, thereby arresting microfilament growth and restraining elongation to remaining free barbed ends. In all CPs characterized to date, a
Incumbent firms face growing pressure to transform their business towards sustainability. However, business models for sustainability (BMfS) and circularity are grounded in fundamentally different institutional logic which, for incumbents, creates tensions with existing business models, structures and routines. How organizations manage tensions from conflicting logics is explored comprehensively i
The aim of our study was to test the hypothesis that administration of Regenerating islet-derived protein 3α (Reg3α), a protein described as having protective effects against oxidative stress and anti-inflammatory activity, could participate in the control of glucose homeostasis and potentially be a new target of interest in the treatment of type 2 diabetes. To that end the recombinant human Reg3α
The case of Lars Findsen and the threat to media by the intelligence community for not exposing what is deemed to be top-secret information of vital interest for the notion of national security, creates several problems that must be addressed.
ABSTRACT: Radiation dosimetry is central to virtually all radiation safety applications, optimization, and research. It relates to various individuals and population groups and to miscellaneous exposure situations-including planned, existing, and emergency situations. The International Commission on Radiological Protection (ICRP) has developed a new computational framework for internal dose estima
Introduction: Thrombocytopenia is frequent in intensive care unit (ICU) patients and has been associated with worse outcome. Platelet transfusions are often used in the management of ICU patients with severe thrombocytopenia. However, the reported frequencies of thrombocytopenia and platelet transfusion practices in the ICU vary considerably. Therefore, we aim to provide contemporary epidemiologic
We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 ×
This paper presents updated Monte Carlo configurations used to model the production of single electroweak vector bosons (W, Z/γ∗) in association with jets in proton-proton collisions for the ATLAS experiment at the Large Hadron Collider. Improvements pertaining to the electroweak input scheme, parton-shower splitting kernels and scale-setting scheme are shown for multi-jet merged configurations ac
City-wide climate adaptation for pluvial flood mitigation requires fast and reliable simulation tools. Considering the limitations of hydrodynamic models at city-scale simulations, data driven models have high potential in the development of surrogate tools. This study explores the Google DeepMind WaveNet™ model architecture to map hydrological response of catchments onto hydraulic parameters of t
In dry sandy soil, soil water is naturally redistributed by forces owing to matric and gravitational potential, and temperature gradients. Occurring shrub vegetation strongly influences these patterns by hydraulic redistribution within the soil. This means that plants can move water from moist to drier soil areas to extract nutrients from the drier soil and enhance nutrient uptake. This incorporat
An experimental investigation of surface pressure distributions (mean and r.m.s.) on two tubes (circular cylinders) mounted in an in-line or tandem arrangement was carried out in a low-speed, closed-circuit wind tunnel. The measurements were mainly performed at a subcritical Reynolds number, Re = 2·0 × 104, at three different turbulence intensities of the approaching cross-flow (0·1, 1·4 and 3·2%)
Hur ska vi komma till rätta med de stora utmaningar som den globala klimatkrisen ställer oss inför? Som individer kan vi alla bidra genom att sortera våra sopor, köra miljövänligt, eller kanske välja att ta cykeln till jobbet. Alla våra individuella bidrag räknas förstås. Men stora delar av vår mänskliga förmåga att förändra världen kommer inte från hur vi agerar var och en, utan från vår gemensamThe world is facing a climate crisis and established firms are set to play a critical role in the societal changes that are needed to defeat it. At the same time, digital technologies are advancing to enable many of the technological solutions that will be required. Together, these two trends, toward greater environmental sustainability and digitalized business, superficially suggest opportunities
Healthy subjects frequently report minor bleedings that are frequently 'background noise' of normality rather than a true disorder. Nevertheless, unexpected or unusual bleeding may be alarming. Thus, the distinction between normal and pathologic bleeding is critical. Understanding the underlying pathologic mechanism in patients with an excessive bleeding is essential for their counseling and treat
Fires are a major hazard resulting in high monetary costs, personal suffering, and irreplaceable losses. The consequences of a fire can be mitigated by early detection systems which increase the potential for successful intervention. The number of false alarms in current systems can for some applications be very high, but could be reduced by increasing the reliability of the detection system by us
Background: Preterm birth has been shown to cause various long-term health issues. Children who were born preterm have also been observed to have more dental behaviour management problems (DBMP) during dental examinations and treatment than children born full term. It is known that dental radiographic examinations can be uncomfortable and cause anxiety in paediatric patients. Thus, our aims were t
The time dependence of ice-nucleating particle (INP) activity is known to exist, yet for simplicity it is often omitted in atmospheric models as an approximation. Hitherto, only limited experimental work has been done to quantify this time dependency, for which published data are especially scarce regarding ambient aerosol samples and longer timescales. In this study, the time dependence of INP ac
In this study, an algae biomass gasification process using a dual fluidized bed with combined power and methanol cogeneration was developed. The gasification process was modeled using Aspen Plus and validated using experimental data of two microalgae species (Nannochloropsis oculata and Dunaliella salina) commonly found on the western coast of Saudi Arabia. The impacts of different operating condi
Shaw’s Pygmalion is commonly thought of as an adaptation of the myth of Pygmalion, the sculptor who fell in love with his own sculpture. However, the name of “Pygmalion” in ancient mythology is shared by Dido’s brother, Pygmalion of Tyre. This article suggests Pygmalion as playing with these two mythological Pygmalions by moving through the play from the myth of Pygmalion the Cypriot sculptor to t
